Abstract
Cervicofacial actinomycosis being one of the unusual infections is of high relevance to a head and neck onco-surgeon. As the diagnosis may be made difficult by its nature to mimic malignancy and egregiously low culture sensitivity, the differential diagnosis for a lesion appearing to be malignant after irradiation does not usually include actinomycotic infection. Treatment usually requires a long-term antibiotic course after confirmation with histopathology, albeit surgical debridement is required in selective cases. Here we report two cases that were clinico-radiologically diagnosed as osteoradionecrosis and histopathological analysis done to rule out cancer recurrence. Unanticipated, they turned out to be cervicofacial actinomycosis, subsequently treated with long-term antibiotics following which the infection subsided.
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References:
Oostman O, Smego RA (2005) Cervicofacial actinomycosis: diagnosis and management. Curr Infect Dis Rep. https://doi.org/10.1007/s11908-005-0030-0
Boyanova L, Kolarov R, Mateva L, Markovska R, Mitov I (2015) Actinomycosis: a frequently forgotten disease. Future Microbiol. https://doi.org/10.2217/fmb.14.130
Peters BM, Jabra-Rizk MA, O’May GA, Costerton JW, Shirtliff ME (2012) Polymicrobial interactions: impact on pathogenesis and human disease. Clin Microbiol Rev 25:193–213. https://doi.org/10.1128/CMR.00013-11
Figueiredo LM, Trindade SC, Sarmento VA, de Oliveira TF, Muniz WR, Valente RO (2013) Actinomycotic osteomyelitis of the mandible: an unusual case. Oral Maxillofac Surg 17:299–302. https://doi.org/10.1007/s10006-012-0381-2
Savoca E, Mehra S, Waldman EH (2019) A case of pediatric cervicofacial actinomyces masquerading as malignancy: case report and review of the literature. Int J Pediatr Otorhinolaryngol 116:204–208. https://doi.org/10.1016/j.ijporl.2018.11.001
Matsuda K, Nakajima H, Khan KN et al (2012) Preoperative diagnosis of pelvic actinomycosis by clinical cytology. Int J Womens Health 4:527–533. https://doi.org/10.2147/IJWH.S35573
Stájer A, Ibrahim B, Gajdács M, Urbán E, Baráth Z (2020) Diagnosis and management of cervicofacial actinomycosis: lessons from two distinct clinical cases. Antibiotics (Basel) 9(4):139. https://doi.org/10.3390/antibiotics9040139
Karanfilian KM, Valentin MN, Kapila R et al (2020) Cervicofacial actinomycosis. Int J Dermatol 59(10):1185–1190. https://doi.org/10.1111/ijd.14833
Martínez-Girón R, Pantanowitz L (2020) “Splendore–Hoeppli” phenomenon. Diagn Cytopathol 48(12):1316–1317. https://doi.org/10.1002/dc.24512
Bulut G, Bayram Y, Bulut MD, Garça MF, Bayram İ (2017) Mandibular actinomyces infection mimicking a malignancy: case report. Turk Patoloji Derg 33:256–258. https://doi.org/10.5146/tjpath.2014.01276
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Murali, T.V., Poorna, T.A., Jayalakshmy, P.L. et al. The Great Imitator: Cervicofacial Actinomycosis Masquerading as Cancer Recurrence. Indian J Otolaryngol Head Neck Surg 75, 3960–3963 (2023). https://doi.org/10.1007/s12070-023-03993-x
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DOI: https://doi.org/10.1007/s12070-023-03993-x