Skip to main content

Advertisement

Log in

The Great Imitator: Cervicofacial Actinomycosis Masquerading as Cancer Recurrence

  • Clinical Report
  • Published:
Indian Journal of Otolaryngology and Head & Neck Surgery Aims and scope Submit manuscript

Abstract

Cervicofacial actinomycosis being one of the unusual infections is of high relevance to a head and neck onco-surgeon. As the diagnosis may be made difficult by its nature to mimic malignancy and egregiously low culture sensitivity, the differential diagnosis for a lesion appearing to be malignant after irradiation does not usually include actinomycotic infection. Treatment usually requires a long-term antibiotic course after confirmation with histopathology, albeit surgical debridement is required in selective cases. Here we report two cases that were clinico-radiologically diagnosed as osteoradionecrosis and histopathological analysis done to rule out cancer recurrence. Unanticipated, they turned out to be cervicofacial actinomycosis, subsequently treated with long-term antibiotics following which the infection subsided.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

Similar content being viewed by others

References:

  1. Oostman O, Smego RA (2005) Cervicofacial actinomycosis: diagnosis and management. Curr Infect Dis Rep. https://doi.org/10.1007/s11908-005-0030-0

    Article  PubMed  Google Scholar 

  2. Boyanova L, Kolarov R, Mateva L, Markovska R, Mitov I (2015) Actinomycosis: a frequently forgotten disease. Future Microbiol. https://doi.org/10.2217/fmb.14.130

    Article  PubMed  Google Scholar 

  3. Peters BM, Jabra-Rizk MA, O’May GA, Costerton JW, Shirtliff ME (2012) Polymicrobial interactions: impact on pathogenesis and human disease. Clin Microbiol Rev 25:193–213. https://doi.org/10.1128/CMR.00013-11

    Article  PubMed  PubMed Central  Google Scholar 

  4. Figueiredo LM, Trindade SC, Sarmento VA, de Oliveira TF, Muniz WR, Valente RO (2013) Actinomycotic osteomyelitis of the mandible: an unusual case. Oral Maxillofac Surg 17:299–302. https://doi.org/10.1007/s10006-012-0381-2

    Article  PubMed  Google Scholar 

  5. Savoca E, Mehra S, Waldman EH (2019) A case of pediatric cervicofacial actinomyces masquerading as malignancy: case report and review of the literature. Int J Pediatr Otorhinolaryngol 116:204–208. https://doi.org/10.1016/j.ijporl.2018.11.001

    Article  PubMed  Google Scholar 

  6. Matsuda K, Nakajima H, Khan KN et al (2012) Preoperative diagnosis of pelvic actinomycosis by clinical cytology. Int J Womens Health 4:527–533. https://doi.org/10.2147/IJWH.S35573

    Article  PubMed  PubMed Central  Google Scholar 

  7. Stájer A, Ibrahim B, Gajdács M, Urbán E, Baráth Z (2020) Diagnosis and management of cervicofacial actinomycosis: lessons from two distinct clinical cases. Antibiotics (Basel) 9(4):139. https://doi.org/10.3390/antibiotics9040139

    Article  PubMed  Google Scholar 

  8. Karanfilian KM, Valentin MN, Kapila R et al (2020) Cervicofacial actinomycosis. Int J Dermatol 59(10):1185–1190. https://doi.org/10.1111/ijd.14833

    Article  PubMed  Google Scholar 

  9. Martínez-Girón R, Pantanowitz L (2020) “Splendore–Hoeppli” phenomenon. Diagn Cytopathol 48(12):1316–1317. https://doi.org/10.1002/dc.24512

    Article  PubMed  Google Scholar 

  10. Bulut G, Bayram Y, Bulut MD, Garça MF, Bayram İ (2017) Mandibular actinomyces infection mimicking a malignancy: case report. Turk Patoloji Derg 33:256–258. https://doi.org/10.5146/tjpath.2014.01276

    Article  PubMed  Google Scholar 

Download references

Funding

The authors did not receive any external source of funding.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to T. Anish Poorna.

Ethics declarations

Conflict of interest

The authors declare no conflict of interest.

Ethical Approval

Not applicable.

Informed Consent

Written informed consent was obtained from the patients for case photos and publishing purpose.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Murali, T.V., Poorna, T.A., Jayalakshmy, P.L. et al. The Great Imitator: Cervicofacial Actinomycosis Masquerading as Cancer Recurrence. Indian J Otolaryngol Head Neck Surg 75, 3960–3963 (2023). https://doi.org/10.1007/s12070-023-03993-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12070-023-03993-x

Keywords

Navigation