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Efficacy of Normal Saline Nasal Spray Added to Standard Treatment Regimen of Chronic Rhinosinusitis: A Randomised Controlled Trial

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Indian Journal of Otolaryngology and Head & Neck Surgery Aims and scope Submit manuscript

Abstract

Chronic Rhinosinusitis is characterized by inflammation of lining of nose and paranasal sinuses leading to nasal blockage/discharge, facial pressure/pain and loss of smell sensation, generally treated with medical therapy initially. Nasal saline irrigation is one of the treatment modalities commonly used to improve symptoms. The aim was to evaluate efficacy of adding normal saline nasal spray to standard treatment regimen of chronic rhinosinusitis. A randomized, controlled, single blinded study with 40 chronic rhinosinusitis patients. Study group was prescribed Normal Saline nasal spray (1 puff in each nostril, thrice daily) along with topical corticosteroids (Mometasone furoate nasal spray, 1 puff in each nostril, twice daily; 1 puff = 50 µg), and oral antibiotics (Amoxicillin + Clavulanic acid, 30 mg/kg, twice daily), and the control group was only prescribed topical corticosteroids and oral antibiotics. Patients were evaluated using Lund–Kennedy endoscopic scores and Sino-Nasal Outcome Test before and after treatment. There was a significant improvement in LKES, with pre-treatment and post-treatment scores for control group being 5.35 ± 2.43 vs 3.70 ± 1.95 respectively (p = 0.0116), whereas for test group, pre-treatment and post-treatment scores were 8.15 ± 2.62 vs 6.05 ± 2.04 respectively (p = 0.0037). Improvement in SNOT-22 scores were observed as well, with pre-treatment and post-treatment scores for control group being 38.90 ± 12.01 vs 25.70 ± 9.21 respectively (p = 0.0002), whereas for test group, pre-treatment and post-treatment scores were 49.85 ± 11.38 vs 31.55 ± 9.91 respectively (p < 0.0001). The study suggests that there is additional benefit in usage of normal saline in form of symptomatic relief as well as clinical improvement.

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The authors did not receive support from any organization for the submitted work.

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Authors and Affiliations

  1. Department of ENT and Head & Neck Surgery, J. N. Medical College, KLE Academy of Higher Education and Research, Belagavi, Karnataka, India

    Anubhuti Janwade, Prashant H. Patil, Nitin R. Ankle, Basavaraj P. Belaldavar, Priti S. Hajare & Keerthana Veenish U. O.

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  1. Anubhuti Janwade
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  2. Prashant H. Patil
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  3. Nitin R. Ankle
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  4. Basavaraj P. Belaldavar
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  5. Priti S. Hajare
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  6. Keerthana Veenish U. O.
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by AJ. The first draft of manuscript was written by AJ. Review and guidance were provided by PHP and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Anubhuti Janwade.

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Janwade, A., Patil, P.H., Ankle, N.R. et al. Efficacy of Normal Saline Nasal Spray Added to Standard Treatment Regimen of Chronic Rhinosinusitis: A Randomised Controlled Trial. Indian J Otolaryngol Head Neck Surg 75, 3453–3456 (2023). https://doi.org/10.1007/s12070-023-03990-0

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