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Mometasone Furoate Use for Recurrent Adenoid Hypertrophy: Randomized Controlled Clinical Trial

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Abstract

Background& Objective: Adenoid hypertrophy (AH) in children is one of the most causes of nasal obstruction and is associated with many nasal and respiratory symptoms. Till now, surgery is the main option for managing the associated symptom of AH. The intranasal steroid has an effective role in the control of allergic rhinitis and associated AH. This work aimed to assess the effects of local mometasone on recurrent AH in children. Patients& Methods: A randomized controlled trial enrolled 39 patients aged between 2 and 15 years with recurrent AH. Those patients were randomly subdivided into three groups; group (A) received topical mometasone furoate (MF), group (B) did not receive any medication, and group (C) received topical normal saline. All groups were followed up for 8 weeks. Results: Patients who received Mometasone furoate had temporary relief of adenoid hypertrophy-related symptoms (84.6%) in comparison to the control group and placebo group during the duration of treatment. After cessation of treatment with local steroids, all cases experienced symptoms caused by adenoid hypertrophy, and by the end of the third month of follow up all cases underwent adenoidectomy. Conclusion: Mometasone furoate can temporarily reduce the adenoid size, reducing symptoms related to adenoid hypertrophy.

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Data Availability

The datasets generated during and/or analyzed during the current study are available.

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Authors and Affiliations

  1. Faculty of Medicine, Assiut University, Assiut, Egypt

    Mohamed Mahmoud Roushdy

  2. Students Hospital, Assiut University, Assiut, Egypt

    Ahmed Aboulwafa Abdel jalil

  3. The Department of otolaryngology, Student Hospital, Assiut University, 71515, Assiut, Egypt

    Ahmed Mahmoud Saeed

Authors
  1. Mohamed Mahmoud Roushdy
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  2. Ahmed Aboulwafa Abdel jalil
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  3. Ahmed Mahmoud Saeed
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Contributions

Mohamed Mahmoud Roushdy: conception and design, critical revision of the submitted manuscript and supervision.

Ahmed Aboulwafa Abdel Jalil: critical revision of the submitted manuscript and supervision.

Ahmed Mahmoud Saeed: collection and analysis of data, writing and submitting the manuscript.

All authors have read and approved the manuscript.

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Correspondence to Ahmed Mahmoud Saeed.

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Ethical committee of Assiut University (IRB No 17100250), Consent was obtained from the study participants before research; informed written consent is available.

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Roushdy, M.M., jalil, A.A.A. & Saeed, A.M. Mometasone Furoate Use for Recurrent Adenoid Hypertrophy: Randomized Controlled Clinical Trial. Indian J Otolaryngol Head Neck Surg 75, 1639–1646 (2023). https://doi.org/10.1007/s12070-023-03539-1

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  • DOI: https://doi.org/10.1007/s12070-023-03539-1

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