Skip to main content
SpringerLink
Log in

Oncological Outcomes Following Transoral CO2 Laser Microsurgery for T1 Glottic Cancer

  • Original Article
  • Published:
Indian Journal of Otolaryngology and Head & Neck Surgery Aims and scope Submit manuscript

Abstract

The objective of this study is to analyze oncological outcomes for treatment of Tis and T1 glottic squamous cell carcinoma after transoral laser microsurgery. This study is retrospective analysis of previously untreated, suspected lesion of glottis, staged cT1a and cT1b squamous cell carcinoma in a tertiary care hospital and 53 patients were included in the study. End points for analysis were local control, overall and disease specific survival rates. The local control, ultimate local control with laser alone, 3-year overall survival, 3-year disease specific survival and organ preservation rates were 86.7, 90.5, 92.4, 98.1 and 98.1% respectively. The involvement of anterior commissure did not show any significant impact on local control or survival. TLM is safe and effective treatment of early glottis cancer, associated with less morbidity and a high percentage of local control, survival and organ preservation rates.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Mendenhall WM, Werning JW, Hinerman RW, Amdur RJ, Villaret DB (2004) Management of T1-T2 glottic carcinomas. Cancer 100(9):1786–1792

    Article  Google Scholar 

  2. Hartl DM (2012) Evidence-based practice: management of glottic cancer. Otolaryngol Clin North Am 45:1143–1161

    Article  Google Scholar 

  3. Strong MS (1975) Laser excision of carcinoma of the larynx. Laryngoscope 85(8):1286–1289

    Article  CAS  Google Scholar 

  4. Strong MS, Jako GJ (1972) Laser surgery in the larynx. Early clinical experience with continuous CO2 laser. Ann Otol Rhinol Laryngol 81(6):791–798

    Article  CAS  Google Scholar 

  5. Succo G, Crosetti E, Bertolin A, Lucioni M, Caracciolo A, Panetta V et al (2016) Benefits and drawbacks of open partial horizontal laryngectomies, Part A: early- to intermediate-stage glottic carcinoma. Head Neck 38(Suppl 1):E333–E340

    Article  Google Scholar 

  6. Mendenhall WM, Amdur RJ, Morris CG, Hinerman RW (2001) T1-T2N0 squamous cell carcinoma of the glottic larynx treated with radiation therapy. J Clin Oncol 19:4029–4036

    Article  CAS  Google Scholar 

  7. Remacle M, Van Haverbeke C, Eckel H, Bradley P, Chevalier D, Djukic V et al (2007) Proposal for revision of the European Laryngological Society classification of endoscopic cordectomies. Eur Arch Otorhinolaryngol 264(5):499–504

    Article  Google Scholar 

  8. Datta R, Sethi A, Singh S, Nilakantan A, Venkatesh MD (2011) Translation and validation of Voice Handicap Index in Hindi. J Laryngol Voice 1(1):12–17

    Article  Google Scholar 

  9. Pfister DG, Laurie SA, Weinstein GS, Mendenhall WM, Adelstein DJ et al (2006) American Society of Clinical Oncology clinical practice guideline for the use of larynx-preservation strategies in the treatment of laryngeal cancer. J Clin Oncol 24(22):3693–3704

    Article  Google Scholar 

  10. Lee HS, Chun BG, Kim SW, Kim ST, Oh JH, Hong JC, Lee KD (2013) Transoral laser microsurgery for early glottic cancer as one-stage single-modality therapy. Laryngoscope 123(11):2670–2674

    Article  Google Scholar 

  11. Van Dijk BA, Gatta G, Capocaccia R, Pierannunzio D, Strojan P, Licitra L (2012) RARECARE Working Group. Rare cancers of the head and neck area in Europe. Eur J Cancer 48(6):783–796

    Article  Google Scholar 

  12. Marur S, Forastiere AA (2008) Head and neck cancer: changing epidemiology, diagnosis, and treatment. Mayo Clin Proceed 83:489–501

    Article  Google Scholar 

  13. Motta G, Esposito E, Motta S, Tartaro G, Testa D (2005) CO2 laser surgery in the treatment of glottic cancer. Head Neck 27(8):733

    Article  Google Scholar 

  14. Vilaseca-González I, Bernal-Sprekelsen M, Blanch-Alejandro JL, Moragas-Lluis M (2003) Complications in transoral CO2 laser surgery for carcinoma of the larynx and hypopharynx. Head Neck 25(5):382–388

    Article  Google Scholar 

  15. Prgomet D, Bacić A, Prstacić R, Janjanin S (2013) Complications of endoscopic CO2 laser surgery for laryngeal cancer and concepts of their management. Coll Antropol 37(4):1373–1378

    PubMed  Google Scholar 

  16. Preuss SF, Cramer K, Klussmann JP, Eckel HE, Guntinas-Lichius O (2009) Transoral laser surgery for laryngeal cancer: outcome, complications and prognostic factors in 275 patients. Eur J Surg Oncol 35(3):235–240

    Article  CAS  Google Scholar 

  17. Cabanillas R, Rodrigo JP, Llorente JL, Suárez V, Ortega P, Suárez C (2004) Functional outcomes of transoral laser surgery of supraglottic carcinoma compared with a transcervical approach. Head Neck 26(8):653–659

    Article  Google Scholar 

  18. Peretti G, Piazza C, Cocco D, De Benedetto L, Del Bon F, Redaelli De Zinis LO et al (2010) Transoral CO(2) laser treatment for T(is)-T(3) glottic cancer: the University of Brescia experience on 595 patients. Head Neck 32(8):977–983

    Article  Google Scholar 

  19. Crespo AN, Chone CT, Gripp FM, Spina AL, Altemani A (2006) Role of margin status in recurrence after CO2 laser endoscopic resection of early glottic cancer. Acta Otolaryngol 126:306–310

    Article  Google Scholar 

  20. Manola M, Moscillo L, Costa G, Barillari U, Lo Sito S, Mastella A et al (2008) Conservative laser microsurgery for T1 glottic carcinoma. Auris Nasus Larynx 35(1):141–147

    Article  CAS  Google Scholar 

  21. Sigston E, de Mones E, Babin E, Hans S, Hartl DM, Clement P et al (2006) Early-stage glottic cancer: oncological results and margins in laser cordectomy. Arch Otolaryngol Head Neck Surg 132(2):147–152

    Article  Google Scholar 

  22. Jeong WJ, Kim H, Ahn JC, Sung MW, Kim KH, Ahn SH (2012) Serial endoscopic analysis of the glottis following laser cordectomy: from an oncological perspective. Lasers Med Sci 27:1025–1031

    Article  Google Scholar 

  23. Pearson BW, Salassa JR (2003) Transoral laser microresection for cancer of the larynx involving the anterior commissure. Laryngoscope 113:1104–1112

    Article  Google Scholar 

  24. Hartl DM, de Mones E, Hans S, Janot F, Brasnu D (2007) Treatment of earlystage glottic cancer by transoral laser resection. Ann Otol Rhinol Laryngol 116:832–836

    Article  Google Scholar 

  25. Rucci L, Romagnoli P, Scala J (2010) CO2 laser therapy in Tis and T1 glottic cancer: indications and results. Head Neck 32:392–398

    PubMed  Google Scholar 

  26. Rucci L, Bocciolini C, Romagnoli P, Olofsson J (2003) Risk factors and prognosis of anterior commissure versus posterior commissure T1-T2 glottic cancer. Ann Otol Rhinol Laryngol 112:223–229

    Article  Google Scholar 

  27. Steiner W, Ambrosch P, Rödel RM, Kron M (2004) Impact of anterior commissure involvement on local control of early glottic carcinoma treated by laser microresection. Laryngoscope 114:1485–1491

    Article  Google Scholar 

  28. Cömert E, Tunçel Ü, Dizman A, Güney YY (2014) Comparison of early oncological results of diode laser surgery with radiotherapy for early glottic carcinoma. Otolaryngol Head Neck Surg 150:818–823

    Article  Google Scholar 

  29. Hakeem AH, Tubachi J, Pradhan SA (2013) Significance of anterior commissure involvement in early glottic squamous cell carcinoma treated with trans-oral CO2 laser microsurgery. Laryngoscope 123(8):1912–1917

    Article  Google Scholar 

  30. Mortuaire G, Francois J, Wiel E, Chevalier D (2006) Local recurrence after CO2 laser cordectomy for early glottic carcinoma. Laryngoscope 116(1):101–105

    Article  CAS  Google Scholar 

  31. Fang TJ, Courey MS, Liao CT, Yen TC, Li HY (2013) Frozen margin analysis as a prognosis predictor in early glottic cancer by laser cordectomy. Laryngoscope 123:1490–1495

    Article  Google Scholar 

  32. Ansarin M, Santoro L, Cattaneo A, Massaro MA, Calabrese L, Giugliano G et al (2009) Laser surgery for early glottic cancer: impact of margin status on local control and organ preservation. Arch Otolaryngol Head Neck Surg 135(4):385–390

    Article  Google Scholar 

  33. Jackel MC, Ambrosch P, Martin A, Steiner W (2007) Impact of re-resection for inadequate margins on the prognosis of upper aerodigestive tract cancer treated by laser microsurgery. Laryngoscope 117:350–356

    Article  Google Scholar 

  34. Michel J, Fakhry N, Duflo S, Lagier A, Mancini J, Dessi P et al (2011) Prognostic value of the status of resection margins after endoscopic laser cordectomy for T1a glottic carcinoma. Eur Ann Otorhinolaryngol Head Neck Dis 128(6):297–300

    Article  CAS  Google Scholar 

  35. Brøndbo K, Fridrich K, Boysen M (2007) Laser surgery of T1a glottic carcinomas; significance of resection margins. Eur Arch Otorhinolaryngol 264:627–630

    Article  Google Scholar 

  36. Lucioni M, Bertolin A, D’Ascanio L, Rizzotto G (2012) Margin photocoagulation in laser surgery for early glottic cancer: impact on disease local control. Otolaryngol Head Neck Surg 146:600–605

    Article  Google Scholar 

  37. Galli A, Giordano L, Sarandria D, Di Santo D, Bussi M (2016) Oncological and complication assessment of CO2 laser-assisted endoscopic surgery for T1-T2 glottic tumours: clinical experience. Acta Otorhinolaryngol Ital 36(3):167–173

    CAS  PubMed  PubMed Central  Google Scholar 

  38. Bradley PJ, Mackenzie K, Wight R, Pracy P, Paleri V, ENT-UK Head & Neck Group (2009) Consensus statement on management in the UK: transoral laser assisted microsurgical resection of early glottic cancer. Clin Otolaryngol 344:367–373

    Article  Google Scholar 

  39. Lee HS, Kim JS, Kim SW, Noh WJ, Kim YJ, Oh D, Hong JC, Lee KD (2016) Voice outcome according to surgical extent of transoral laser microsurgery for T1 glottic carcinoma. Laryngoscope 126(9):2051–2056

    Article  Google Scholar 

  40. Chu PY, Hsu YB, Lee TL, Fu S, Wang LM, Kao YC (2012) Longitudinal analysis of voice quality in patients with early glottic cancer after transoral laser microsurgery. Head Neck 34(9):1294–1298

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Otorhinolaryngology and Head & Neck Surgery, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, 110095, India

    Ankur Batra, A. Goyal, M. Goyal & S. Goel

Authors
  1. Ankur Batra
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Goyal
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Goyal
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. Goel
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ankur Batra.

Ethics declarations

Conflict of interest

All authors declare that they have no conflict of interest.

Ethical Approval

All procedures performed in the study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This article does not contain any study with animals performed by any of the authors.

Informed Consent

Informed consent was obtained from the participant included in the study.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Batra, A., Goyal, A., Goyal, M. et al. Oncological Outcomes Following Transoral CO2 Laser Microsurgery for T1 Glottic Cancer. Indian J Otolaryngol Head Neck Surg 71 (Suppl 1), 542–547 (2019). https://doi.org/10.1007/s12070-018-1394-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12070-018-1394-4

Keywords

Search

Navigation