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Sutureless valves—are we there yet? Evidence from the PERSIST-AVR trial

  • Critical Appraisal of Trials
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Indian Journal of Thoracic and Cardiovascular Surgery Aims and scope Submit manuscript

Abstract

Sutur eless valves have emerged as another option for implantation of a biological valve. Several benefits of sutureless valves have been reported in the literature. However, concerns have been raised over increased incidence of para-valvular leak and need for permanent pacemaker implantation. Most of the evidence has been obtained from observational and retrospective single institutional series. The Perceval Sutureless Implant Versus Standard-Aortic Valve Replacement (PERSIST-AVR) trial is the first multicentric randomized control trial to compare sutureless valves with standard bio-prosthesis. Evidence from this trial has been critically analyzed in this review.

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References

  1. Fischlein T, Folliguet T, Meuris B, et al. Sutureless versus conventional bioprostheses for aortic valve replacement in severe symptomatic aortic valve stenosis. J Thorac Cardiovasc Surg. 2021;161:920–32.

    Article  Google Scholar 

  2. Gersak B, Fischlein T, Folliguet TA, et al. Sutureless, rapid deployment valves and stented bioprosthesis in aortic valve replacement: recommendations of an International Expert Consensus Panel. Eur J Cardiothorac Surg. 2016;49:709–18.

    Article  Google Scholar 

  3. Lim C-Y, In J. Randomization in clinical studies. Korean J Anesthesiol. 2019;72:221–32.

    Article  Google Scholar 

  4. Meco M, Montisci A, Miceli A, et al. Sutureless Perceval aortic valve versus conventional stented bioprostheses: meta-analysis of postoperative and midterm results in isolated aortic valve replacement. J Am Heart Assoc. 2018;7:e006091.

    Article  Google Scholar 

  5. Dedeilias P, Baikoussis NG, Prappa E, Asvestas D, Argiriou M, Charitos C. Aortic valve replacement in elderly with small aortic root and low body surface area; the Perceval S valve and its impact in effective orifice area. J Cardiothorac Surg. 2016;11:54.

    Article  Google Scholar 

  6. Ensminger S, Fujita B, Bauer T, et al. Rapid deployment versus conventional bioprosthetic valve replacement for aortic stenosis. J Am Coll Cardiol. 2018;71:1417–28.

    Article  Google Scholar 

  7. Sohn SH, Kang Y, Kim JS, Choi JW, Jang M-J, Hwang HY. Direct comparison of rapid deployment versus sutureless aortic valve replacement: a meta-analysis. J Thorac Dis. 2021;13:2203–15.

    Article  Google Scholar 

  8. Sohn SH, Jang M-J, Hwang HY, Kim KH. Rapid deployment or sutureless versus conventional bioprosthetic aortic valve replacement: a meta-analysis. J Thorac Cardiovasc Surg. 2018;155:2402-2412.e5.

    Article  Google Scholar 

  9. Muneretto C, Alfieri O, Cesana BM, et al. A comparison of conventional surgery, transcatheter aortic valve replacement, and sutureless valves in “real-world” patients with aortic stenosis and intermediate- to high-risk profile. J Thorac Cardiovasc Surg. 2015;150:1570–7.

    Article  Google Scholar 

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Correspondence to Pradeep Narayan.

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Narayan, P. Sutureless valves—are we there yet? Evidence from the PERSIST-AVR trial. Indian J Thorac Cardiovasc Surg 38, 108–110 (2022). https://doi.org/10.1007/s12055-021-01289-9

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  • DOI: https://doi.org/10.1007/s12055-021-01289-9

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