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Peri-procedural myocardial infarction: what is in a definition?

  • Critical Appraisal of Trials
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Indian Journal of Thoracic and Cardiovascular Surgery Aims and scope Submit manuscript

Abstract

Peri-procedural myocardial infarction (PMI) is an important outcome measure in several trials. However, there is no consensus regarding the definition of PMI. There is significant variability in terms of biomarkers used, the threshold values, the requirement for additional supporting evidence, and even the duration until which PMI can be said to occur. This lack of clarity leads to inappropriate comparisons between trials. Besides, the outcome of a trial and the inferences drawn are completely altered by using a different definition. Thus, there is a pressing need to formulate a uniform definition for PMI in future studies.

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References

  1. Stone GW, Kappetein AP, Sabik JF, et al. Five-year outcomes after PCI or CABG for left main coronary disease. N Engl J Med. 2019;381:1820–30.

    Article  Google Scholar 

  2. Moussa ID, Klein LW, Shah B, et al. Consideration of a new definition of clinically relevant myocardial infarction after coronary revascularization: an expert consensus document from the Society for Cardiovascular Angiography and Interventions (SCAI). J Am Coll Cardiol. 2013;62:1563–70.

    Article  Google Scholar 

  3. Maron DJ, Hochman JS, Reynolds HR, et al. Initial invasive or conservative strategy for stable coronary disease. N Engl J Med. 2020;382:1395–407.

    Article  Google Scholar 

  4. Serruys PW, Morice M-C, Kappetein AP, et al. Percutaneous coronary intervention versus coronary-artery bypass grafting for severe coronary artery disease. N Engl J Med. 2009;360:961–72.

    Article  CAS  Google Scholar 

  5. Thygesen K, Alpert JS, Jaffe AS, Simoons ML, Chaitman BR, White HD. Third universal definition of myocardial infarction. Eur Heart J. 2012;33:2551–67.

    Article  Google Scholar 

  6. Thygesen K, Alpert JS, Jaffe AS, et al. Fourth universal definition of myocardial infarction (2018). Circulation. 2018;138:e618–51.

    Article  Google Scholar 

  7. Hara H, Serruys PW, Takahashi K, et al. Impact of peri-procedural myocardial infarction on outcomes after revascularization. J Am Coll Cardiol. 2020;76:1622–39.

    Article  CAS  Google Scholar 

  8. Gregson J, Stone GW, Ben-Yehuda O, et al. Implications of alternative definitions of peri-procedural myocardial infarction after coronary revascularization. J Am Coll Cardiol. 2020;76:1609–21.

    Article  CAS  Google Scholar 

  9. Gaudino M, Brophy JM. The controversy on the treatment of left main coronary artery disease. J Thorac Cardiovasc Surg. 2020;S0022-5223(20):33039–7. https://doi.org/10.1016/j.jtcvs.2020.08.122.

    Article  Google Scholar 

  10. Cutlip DE. Procedural myocardial infarction: definitions everywhere, but not any that may fit. J Am Coll Cardiol. 2020;76:1640–3.

    Article  Google Scholar 

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Correspondence to Pradeep Narayan.

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Narayan, P. Peri-procedural myocardial infarction: what is in a definition?. Indian J Thorac Cardiovasc Surg 37, 473–475 (2021). https://doi.org/10.1007/s12055-021-01203-3

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