Abstract
Peri-procedural myocardial infarction (PMI) is an important outcome measure in several trials. However, there is no consensus regarding the definition of PMI. There is significant variability in terms of biomarkers used, the threshold values, the requirement for additional supporting evidence, and even the duration until which PMI can be said to occur. This lack of clarity leads to inappropriate comparisons between trials. Besides, the outcome of a trial and the inferences drawn are completely altered by using a different definition. Thus, there is a pressing need to formulate a uniform definition for PMI in future studies.
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Stone GW, Kappetein AP, Sabik JF, et al. Five-year outcomes after PCI or CABG for left main coronary disease. N Engl J Med. 2019;381:1820–30.
Moussa ID, Klein LW, Shah B, et al. Consideration of a new definition of clinically relevant myocardial infarction after coronary revascularization: an expert consensus document from the Society for Cardiovascular Angiography and Interventions (SCAI). J Am Coll Cardiol. 2013;62:1563–70.
Maron DJ, Hochman JS, Reynolds HR, et al. Initial invasive or conservative strategy for stable coronary disease. N Engl J Med. 2020;382:1395–407.
Serruys PW, Morice M-C, Kappetein AP, et al. Percutaneous coronary intervention versus coronary-artery bypass grafting for severe coronary artery disease. N Engl J Med. 2009;360:961–72.
Thygesen K, Alpert JS, Jaffe AS, Simoons ML, Chaitman BR, White HD. Third universal definition of myocardial infarction. Eur Heart J. 2012;33:2551–67.
Thygesen K, Alpert JS, Jaffe AS, et al. Fourth universal definition of myocardial infarction (2018). Circulation. 2018;138:e618–51.
Hara H, Serruys PW, Takahashi K, et al. Impact of peri-procedural myocardial infarction on outcomes after revascularization. J Am Coll Cardiol. 2020;76:1622–39.
Gregson J, Stone GW, Ben-Yehuda O, et al. Implications of alternative definitions of peri-procedural myocardial infarction after coronary revascularization. J Am Coll Cardiol. 2020;76:1609–21.
Gaudino M, Brophy JM. The controversy on the treatment of left main coronary artery disease. J Thorac Cardiovasc Surg. 2020;S0022-5223(20):33039–7. https://doi.org/10.1016/j.jtcvs.2020.08.122.
Cutlip DE. Procedural myocardial infarction: definitions everywhere, but not any that may fit. J Am Coll Cardiol. 2020;76:1640–3.
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Narayan, P. Peri-procedural myocardial infarction: what is in a definition?. Indian J Thorac Cardiovasc Surg 37, 473–475 (2021). https://doi.org/10.1007/s12055-021-01203-3
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DOI: https://doi.org/10.1007/s12055-021-01203-3