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Meta-analysis of the Selected Genetic Variants in Immune-Related Genes and Multiple Sclerosis Risk

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Abstract

Previous studies have suggested that certain variants in immune-related genes may participate in the pathogenesis of multiple sclerosis (MS), including rs17824933 in the CD6 gene, rs1883832 in the CD40 gene, rs2300747 in the CD58 gene, rs763361 in the CD226 gene, rs16944 in the IL-1β gene, rs2243250 in the IL-4 gene, and rs12722489 and rs2104286 in the IL-2Rα gene. However, the results remained inconclusive and conflicting. In view of this, a comprehensive meta-analysis including all eligible studies was conducted to investigate the association between these 8 selected genetic variants and MS risk. Up to June 2023, 64 related studies were finally included in this meta-analysis. The odds ratios (ORs) and corresponding 95% confidence intervals (CIs) calculated by the random-effects model were used to evaluate the strength of association. Publication bias test, sensitivity analyses, and trial sequential analysis (TSA) were conducted to examine the reliability of statistical results. Our results indicated that rs17824933 in the CD6 gene, rs1883832 in the CD40 gene, rs2300747 in the CD58 gene, rs763361 in the CD226 gene, and rs12722489 and rs2104286 in the IL-2Rα gene may serve as the susceptible factors for MS pathogenesis, while rs16944 in the IL-1β gene and rs2243250 in the IL-4 gene may not be associated with MS risk. However, the present findings need to be confirmed and reinforced in future studies.

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Data Availability

This was a meta-analysis, so no new data sets were created. All the analyses were based on data extracted from previously published studies that have been cited in References.

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Funding

This work was supported by the Fundamental Research Funds for the Central Universities (WUT: 2020IB029).

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  1. Weiguang Zhou and Weiqiong Hu contributed equally to this work.

Authors and Affiliations

  1. Department of Biological Science and Technology, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, 430070, China

    Weiguang Zhou, Weiqiong Hu, Jiaxi Liao, Bifeng Chen & Jing Li

  2. Institute of WUT-AMU, Wuhan University of Technology, Wuhan, 430070, China

    Weiqiong Hu, Lingyu Tang, Xiaorui Ma, Zhiyan Yu & Bifeng Chen

  3. Department of Pharmaceutical Engineering, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, 430070, China

    Meifang Qi

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Contributions

BC and JL designed and supervised the study. WZ, WH, JL, and ZY reviewed and collected the data of all eligible studies independently. WZ and LT analyzed the data. WH and XM checked the statistical results. WZ and WH wrote the manuscript. BC, JL, and MQ revised the manuscript critically and made the final approval of the manuscript. All authors reviewed the manuscript and approved the final manuscript.

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Correspondence to Bifeng Chen or Jing Li.

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Zhou, W., Hu, W., Tang, L. et al. Meta-analysis of the Selected Genetic Variants in Immune-Related Genes and Multiple Sclerosis Risk. Mol Neurobiol (2024). https://doi.org/10.1007/s12035-024-04095-7

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