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Role of plectin and its interacting molecules in cancer

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Abstract

Plectin, as the cytolinker and scaffolding protein, are widely expressed and abundant in many tissues, and has involved in various cellular activities contributing to tumorigenesis, such as cell adhesion, migration, and signal transduction. Due to the specific expression and differential localization of plectin in cancer, most researchers focus on the role of plectin in cancer, and it has emerged as a potent driver of malignant hallmarks in many human cancers, which provides the possibility for plectin to be widely used as a biomarker and therapeutic target in the early diagnosis and targeted drug delivery of the disease. However, there is still a lack of systematic review on the interaction molecules and mechanism of plectin. Herein, we summarized the structure, expression and function of plectin, and mainly focused on recent studies on the functional and physical interactions between plectin and its interacting molecules, shedding light on the potential of targeting plectin for cancer therapy.

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The data and materials presented in this study are available on request from the corresponding author.

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Funding

This study was supported by grants from the Science and Technology Project of Xuzhou (KC20119), and the National Natural Science Foundation of China (81972377).

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  1. Keyu Gao and Zhimin Gao have contributed equally to this work.

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  1. Department of Urology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, Jiangsu, China

    Keyu Gao, Zhimin Gao & Hailong Li

  2. Cancer Institute, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, 221004, Jiangsu, China

    Mingyi Xia & Jiehui Di

  3. Center of Clinical Oncology, The Affiliated Hospital of Xuzhou Medical University, 99 West Huaihai Road, Xuzhou, 221002, Jiangsu, China

    Mingyi Xia & Jiehui Di

  4. Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, 221004, Jiangsu, China

    Mingyi Xia & Jiehui Di

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  1. Keyu Gao
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JD: the conception and design of this manuscript; KG and ZG: writing and editing; MX: collecting and preparing related papers; HL: supervision and revision.

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Gao, K., Gao, Z., Xia, M. et al. Role of plectin and its interacting molecules in cancer. Med Oncol 40, 280 (2023). https://doi.org/10.1007/s12032-023-02132-4

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