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AEG-1 is associated with tumor progression in nonmuscle-invasive bladder cancer

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Abstract

Astrocyte elevated gene-1 (AEG-1), a novel oncoprotein, has been implicated in oncogenesis and cancer progression in various types of human cancers. Here, immunohistochemistry was used to detect AEG-1 expression in nonmuscle-invasive bladder cancer (NMIBC), and these data were examined for correlation with clinicopathological parameters, and prognosis. Immunohistochemical analysis revealed that AEG-1 expression was significantly higher in bladder cancer tissues than that in normal tissues. High expression of AEG-1 was found in 45 % of bladder cancers and significantly associated with tumor grade (P = 0.002) and progression (P = 0.028). The Kaplan–Meier survival analysis demonstrated that AEG-1 expression was significantly associated with shorter progression-free survival (P = 0.0011). Multivariate analysis further demonstrated that AEG-1 was an independent prognostic factor for patients with BC. AEG-1 protein may contribute to the malignant progression of bladder cancer, and present as a novel marker to predict the progression of NMIBC.

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Acknowledgments

This work was supported by Grants from the National Key Clinical Specialty Project of China’s Ministry of Health and the Science and Technology Committee of Shanghai Municipal (No. 12ZR1417700).

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There is no conflict of interest.

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Authors and Affiliations

  1. Department of Urology, Ren Ji Hospital, Shanghai Jiao Tong University, Shanghai, 200001, China

    Guoliang Yang, Lianhua Zhang, Shilong Lin, Haige Chen, Ming Cao, Dongming Liu, Yi-ran Huang & Juanjie Bo

  2. Clinical Stem Cell Research Center, Ren Ji Hospital, Shanghai Jiao Tong University, Shanghai, 200001, China

    Linfeng Li & Mengyao Liu

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  1. Guoliang Yang
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  2. Lianhua Zhang
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  3. Shilong Lin
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  4. Linfeng Li
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  7. Ming Cao
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  8. Dongming Liu
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  9. Yi-ran Huang
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Correspondence to Juanjie Bo.

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Guoliang Yang and Lianhua Zhang have contributed equally to this work.

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Yang, G., Zhang, L., Lin, S. et al. AEG-1 is associated with tumor progression in nonmuscle-invasive bladder cancer. Med Oncol 31, 986 (2014). https://doi.org/10.1007/s12032-014-0986-4

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  • DOI: https://doi.org/10.1007/s12032-014-0986-4

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