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Clinical, Imaging Characteristics and Outcome of Intracerebral Hemorrhage Caused by Structural Vascular Lesions

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Abstract

Background

The objective of this study was to investigate the clinical, imaging, and outcome characteristics of intracerebral hemorrhage (ICH) caused by structural vascular lesions.

Methods

We retrospectively analyzed data from a prospective observational cohort study of patients with spontaneous ICH admitted to the First Affiliated Hospital of Chongqing Medical University between May 2016 and April 2021. Good outcome was defined as modified Rankin Scale score of 0–3 at 3 months. The clinical and imaging characteristics were compared between primary ICH and ICH caused by structural vascular lesions. Multivariable logistic regression analysis was performed to test the associations of etiology with clinical outcome.

Results

All patients enrolled in this study were Asian. Compared with patients with primary ICH, those with structural vascular lesions were younger (48 vs. 62 years, P < 0.001), had a lower incidence of hypertension (26.4% vs. 81.7%, P < 0.001) and diabetes (7.4% vs. 16.2%, P = 0.003), and had mostly lobar hemorrhages (49.1% vs. 22.8%). ICH from structural vascular lesions had smaller baseline hematoma volume (8.4 ml vs. 13.8 ml, P = 0.010), had lower mortality rate at 30 days and 3 months (5.8% vs. 12.0%, P = 0.020; 6.7% vs. 14.8%, P = 0.007), and are associated with better functional outcome at 3 months (88% vs.70.3%, P < 0.001).

Conclusions

Compared with primary ICH, ICH due to vascular lesions has smaller hematoma volume and less severe neurological deficit at presentation and better functional outcomes.

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Funding

This work was supported by the National Natural Science Foundation of China (Grant No. 82071337), the National Key R&D Program of China (Grant Nos. 2018YFC1312200 and 2018YFC1312203), the Chongqing High-end Young Investigator Project (Grant No. 2019GDRC005), the Science and Technology Innovation Project of “Chengdu-Chongqing Economic Circle” (Grant No. KJCXZD2020019), the Chongqing Innovation Support Program for Returned Overseas Chinese Scholars (Grant No. cx2020002), and Chongqing Science Fund for Distinguished Young Scholars (Grant No.cstc2021jcyj-jqX0029).

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Authors and Affiliations

  1. Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Rd, Chongqing, 400016, China

    Xiao-Fang Wu, Lan Deng, Xin-Ni Lv, Zuo-Qiao Li, Zi-Jie Wang, Xiao Hu, Ming-Jun Pu, Chu Chen & Qi Li

  2. Department of Neurology, Yongchuan Hospital of Chongqing Medical University, Chongqing, China

    Li-Bo Zhao

  3. Chongqing Key Laboratory of Cerebrovascular Disease Research, Chongqing, China

    Li-Bo Zhao & Qi Li

Authors
  1. Xiao-Fang Wu
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  2. Lan Deng
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  3. Xin-Ni Lv
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  4. Zuo-Qiao Li
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  5. Zi-Jie Wang
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  6. Xiao Hu
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  7. Ming-Jun Pu
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  8. Chu Chen
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  9. Li-Bo Zhao
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  10. Qi Li
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Contributions

QL, X-FW: study concept and design. X-FW, LD, X-NL, Z-QL, Z-JW, XH, M-JP, CC and L-BZ: acquisition of data. X-FW: statistical analysis. Analysis and interpretation of data: all authors. X-FW: drafting of the manuscript. QL, X-FW: critical revision of the manuscript for important intellectual content. QL: obtained funding. QL: study supervision. The authors approved the final manuscript.

Corresponding author

Correspondence to Qi Li.

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The authors declare no competing interests.

Ethical Approval/Informed Consent

The Ethics Committee of the First Affiliated Hospital of Chongqing Medical University approved the study protocol.

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Wu, XF., Deng, L., Lv, XN. et al. Clinical, Imaging Characteristics and Outcome of Intracerebral Hemorrhage Caused by Structural Vascular Lesions. Neurocrit Care 40, 743–749 (2024). https://doi.org/10.1007/s12028-023-01831-0

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  • DOI: https://doi.org/10.1007/s12028-023-01831-0

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