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Teratoma of the Sellar Region: a Case Report

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Abstract

The case report describes a teratoma of the sellar region with a gland forming and an immature, relatively clear undifferentiated component without signs of anaplasia. Both components express TTF-1 indicating their presumable origin in the neurohypophysis as part of the circumventricular organs. The differential diagnosis includes pituitary adenoma and spindle cell oncocytoma with inclusion of Rathke’s cleft cyst, pituitary blastoma, yolk sac tumor, and other germ cell tumors. The prognosis is the same as in the immature teratomas in the gonads, specifically unclear.

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Acknowledgments

The funding for the German Pituitary Tumor Registry to WS from Novartis Pharma GmbH (Nuremberg, Germany), Novo Nordisk Pharma GmbH (Mainz, Germany), Pfizer Pharma GmbH (Berlin, Germany), and Ipsen Pharma GmbH (Berlin, Germany) is gratefully acknowledged. We thank all colleagues for sending tumor material to the German Pituitary Tumor Registry.

Authors’ Contributions

W. Saeger: Histopathology, immunocytochemistry, and conception

A. Ebrahim: First examinations of specimens and proof reading of manuscript

R. Beschorner: First examinations of specimens

H. Spital: Clinical examinations

J. Honegger: Clinical examinations and surgery

W. Wilczak: Immunocytochemistry

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Authors and Affiliations

  1. Institutes of Pathology and Neuropathology of the University of Hamburg, UKE, Martinistraße 52, 20246, Hamburg, Germany

    Wolfgang Saeger

  2. Department of Neuropathology, Institute of Pathology and Neuropathology of the University of Tübingen, 72076, Tübingen, Germany

    Azadeh Ebrahimi & Rudi Beschorner

  3. Hormone Center Karlsruhe, 76133, Karlsruhe, Germany

    Hildegard Spital

  4. Clinic of Neurosurgery of the University of Tübingen, 72076, Tübingen, Germany

    Jürgen Honegger

  5. Institute of Pathology of the University of Hamburg, UKE, 20246, Hamburg, Germany

    Waldemar Wilczak

Authors
  1. Wolfgang Saeger
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  2. Azadeh Ebrahimi
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  3. Rudi Beschorner
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  4. Hildegard Spital
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  5. Jürgen Honegger
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  6. Waldemar Wilczak
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Correspondence to Wolfgang Saeger.

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The authors declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study, formal consent is not required.

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Saeger, W., Ebrahimi, A., Beschorner, R. et al. Teratoma of the Sellar Region: a Case Report. Endocr Pathol 28, 315–319 (2017). https://doi.org/10.1007/s12022-016-9465-0

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  • DOI: https://doi.org/10.1007/s12022-016-9465-0

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