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Nodal metastasis in noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)

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Abstract

The term noninvasive tumor with a follicular growth pattern and nuclear features of papillary thyroid cancer (NIFTP) is used to describe a tumor currently considered as a pre-malignant lesion for which a conservative therapeutic approach (i.e., lobectomy without radioiodine therapy) is strongly suggested. However, some patients with NIFTP and loco-regional or distant metastases have been already reported. We present an adult male patient with a final histological diagnosis of NIFTP and lymph node metastasis noted at post-therapy whole-body scintigraphy performed some days after radioiodine therapy.

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Data availability

The study was conducted in accordance with applicable regulations. For more information on the study and data sharing, qualified researchers may contact the corresponding author, Prof. Alfredo Campennì (acampenni@unime.it).

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Authors and Affiliations

  1. Unit of Nuclear Medicine, Department of Biomedical and Dental Sciences and Morpho-Functional Imaging, University of Messina, Messina, Italy

    Alfredo Campennì & Massimiliano Siracusa

  2. Department of Surgical, Medical, Molecular Pathology and Clinical Area, University of Pisa, Pisa, Italy

    Liborio Torregrossa

  3. Department of Human Pathology of Adulthood and Childhood DETEV “G. Barresi”, Endocrinology Unit, University of Messina, 98125, Messina, Italy

    Rosaria Maddalena Ruggeri

  4. Department of Oncology and Nuclear Medicine, University Hospital Center Sestre Milosrdnice, Zagreb, Croatia

    Petra Petranović Ovčariček

  5. School of Medicine, University of Zagreb, Zagreb, Croatia

    Petra Petranović Ovčariček

  6. Clinic for Nuclear Medicine, University Hospital and University of Zurich, Zurich, Switzerland

    Luca Giovanella

Authors
  1. Alfredo Campennì
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  2. Liborio Torregrossa
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  3. Rosaria Maddalena Ruggeri
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  4. Petra Petranović Ovčariček
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  5. Massimiliano Siracusa
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  6. Luca Giovanella
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Contributions

Alfredo Campennì and Luca Giovanella contributed to the study conception and design. Material preparation and analysis were performed by Liborio Torregrossa. Data collection was performed by Massimiliano Siracusa. The first draft of the manuscript was written by Alfredo Campennì and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.”

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Correspondence to Alfredo Campennì.

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The patient described in the present study was fully informed on the use of his data and provided a written informed consensus.

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The authors affirm that the participant provided informed consent for publication of the images in Fig. 1.

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Campennì, A., Torregrossa, L., Ruggeri, R.M. et al. Nodal metastasis in noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). Endocrine (2024). https://doi.org/10.1007/s12020-024-03719-1

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  • DOI: https://doi.org/10.1007/s12020-024-03719-1

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