Skip to main content
Log in

Utility of intraoperative neuromonitoring in detecting recurrent nerve’s anatomical anomalies during thyroidectomy

  • Endocrine Surgery
  • Published:
Endocrine Aims and scope Submit manuscript

Abstract

Anatomical variations such as a non-recurrent laryngeal nerve (NRLN) are very rare (reported rates within 0.6–1% to the right side and only four cases to the left side) but they can lead to serious risk of nerve lesion during thyroidectomy. It is known that to prevent inferior laryngeal nerve lesions, it is mandatory to obtain a correct and wide exposure of the nerve during all kind of thyroid surgeries but in case of laryngeal nerve position anomalies, it is hard to achieve a safe nerve identification. Continuous intraoperative neuromonitoring (C-IONM) technology can detect the presence of NRLN. In this study we present seven cases of NRLN incidentally found during our last 10-year experience, in a total of 1074 procedures, including total thyroidectomy and lobectomy. Three out of seven cases were identified with the help of C-IONM. On the other hand, the other four cases of non-recurrent laryngeal nerve were identified during an extensive dissection of the thyroid lodge. We registered no nerve palsy in the group of patients who underwent surgery with the help of C-IONM, while we had two nerve palsies (out of four cases) in the group of patients without the help of C-IONM. In our experience we also registered a reduction of surgery time when we used the C-IONM. In our opinion C-IONM is a safe method to discover anatomical anomalies such as a non-recurrent laryngeal nerve and may help to reduce nerve palsy rate.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. G.R. Jatzko, P.H. Lisborg, M.G. Muller, V.M. Wette, Recurrent nerve palsy after thyroid operations-principal nerve identification and a literature review. Surgery. 115(2), 139–144 (1994)

    CAS  PubMed  Google Scholar 

  2. C.C. Lubitz, D.H. Kraus, G.W. Randolph, R.J. Wong, Chapter 11: The nonrecurrent inferior laryngeal nerve in The Recurrent and Superior Laryngeal Nerves, ed. by G.W. Randolph (Springer International Publishing Switzerland, 2016)

  3. C. Sciumè, G. Geraci, F. Pisello, F. Li Volsi, T. Facella, A. Licata, G. Modica, Il nervo ricorrente che non ricorre. Esperienza personale. G Chir 26(11/12), 434–437 (2005)

  4. M. Citton, G. Viel, M. Iacobone, Neck ultrasonography for detection of non-recurrent laryngeal nerve. Gland Surg. 5(6), 583–590 (2016). https://doi.org/10.21037/gs.2016.11.07

    Article  PubMed  PubMed Central  Google Scholar 

  5. C. Avisse, C. Marcus, J.F. Delattre, et al., Right nonre-current inferior laryngeal nerve and arteria lusoria: the diagnostic and therapeutic implications of an anatomic anomaly. Review of 17 cases. Surg. Radiol. Anat. 20(3), 227–232 (1998).

    Article  CAS  Google Scholar 

  6. M. Morais, J. Capela-Costa, L. Matos-Lima, J. Costa-Maia, Nonrecurrent laryngeal nerve and associated anatomical variations: the art of prediction. Eur. Thyroid J. 4(4), 234–238 (2015). https://doi.org/10.1159/000438751

    Article  PubMed  PubMed Central  Google Scholar 

  7. D.C. Shedd, G.C. Burget, Identification of the recurrent laryngeal nerve. Arch. Surg. 92, 861–864 (1966). https://doi.org/10.1001/archsurg.1966.01320240049010

    Article  CAS  PubMed  Google Scholar 

  8. G.W. Randolph, H. Dralle; International Nerve Monitoring Study Group, Electrophysiologic recurrent laryngeal nerve monitoring during thyroid and parathyroid surgery: International Standards Guideline Statement. Laryngoscope 121, S1–S16 (2006). https://doi.org/10.1002/lary.21119

    Article  Google Scholar 

  9. G. Dionigi, M. Barczyński, F.Y. Chiang, H. Dralle, M. Duran Poveda, I. Iacobone, C.P. Lombardi, G. Materazzi, R. Mihai, G.W. Randolp, A. Sitges-Serra, Why monitor the recurrent laryngeal nerve in thyroid surgery? J. Endocrinol. Investig. 33, 819–822 (2010). https://doi.org/10.1007/BF03350349

    Article  CAS  Google Scholar 

  10. A. Mangano, H.Y. Kim, C.W. Wu, S. Rausei, S. Hui, L. Xiaoli, F.Y. Chiang, D.H. Roukos, G.D. Lianos, E. Volpi, G. Dionigi, Continuous intraoperative neuromonitoring in thyroid surgery: safety analysis of 400 consecutive electrode probe placements with standardized procedures. Head. Neck. 38(Suppl 1), E1568–E1574 (2016). https://doi.org/10.1002/hed.24280

    Article  PubMed  Google Scholar 

  11. H. Dralle, C. Sekulla, K. Lorenz, M. Brauckhoff, A. Machens; German IONM Study Group, Intraoperative monitoring of the recurrent laryngeal nerve and thyroid surgery. World J. Surg. 32, 1358–1366 (2008). https://doi.org/10.1007/s00268-008-9483-2

    Article  CAS  PubMed  Google Scholar 

  12. C. Bellotti, M.G. Capponi, M. Cinquepalmi, G. Castagnola, S. Marchetta, F. Mallozzi, M. Pezzatini, A. Brescia, MIVAT: the last 2 years experience, tips and techniques after more than 10 years. Surg. Endosc. 32(5), 2340–2344 (2018). https://doi.org/10.1007/s00464-017-5929-7

  13. G. Dionigi, H. Dralle, W. Liddy, D. Kamani, N. Kyriazidis, G.W. Randolph, Chapter 14: IONM of the recurrent laryngeal nerve in The Recurrent and Superior Laryngeal Nerves, ed. by G.W. Randolph (Springer International Publishing Switzerland, 2016)

  14. W. Liddy, S.R. Barber, M. Cinquepalmi, B.M. Lin, S. Patricio, N. Kyriazidis, C. Bellotti, D. Kamani, S. Mahamad, H. Dralle, R. Schneider, G. Dionigi, M. Barczynski, C.W. Wu, F.Y. Chiang, G. Randolph, The electrophysiology of thyroid surgery: electrophysiologic and muscular responses with stimulation of the vagus nerve, recurrent laryngeal nerve, and external branch of the superior laryngeal nerve. Laryngoscope 127(3), 764–771 (2017). https://doi.org/10.1002/lary.26147

    Article  PubMed  Google Scholar 

  15. B. Wojtczak, K. Kaliszewski, M. Bolanowski, M. Barczyński, A functional assessment of anatomical variants of the recurrent laryngeal nerve during thyroidectomies using neuromonitoring. Endocrine 59(1), 82–89 (2018). https://doi.org/10.1007/s12020-017-1466-3

    Article  CAS  PubMed  Google Scholar 

  16. K.N. Patel, L. Yip, C.C. Lubitz, E.G. Grubbs, B.S. Miller, W. Shen, P. Angelos, H. Chen, G.M. Doherty, T.J. Fahey, E. Kebebew, V.A. Livolsi, N.D. Perrier, J.A. Sipos, J.A. Sosa, D. Steward, R.P. Tufano, C.R. McHenry, S.E. Carty, The American Association of Endocrine Surgeons Guidelines for the Definitive Surgical Management of Thyroid Disease in Adults. Ann. Surg. 271, e21–e93 (2020)

    Article  Google Scholar 

  17. A. Devèze, F. Sebag, J. Hubbard, M. Jaunay, S. Maweja, J.-F. Henry, Identification of patients with a non-recurrent inferior laryngeal nerve by duplex ultrasound of the brachiocephalic artery Surgical and Radiologic. Anatomy 25, 263–269 (2003)

    Google Scholar 

  18. B. Wojtczak, K. Kaliszewski, K. Sutkowski, M. Głód, M. Barczyński, The learning curve for intraoperative neuromonitoring of the recurrent laryngeal nerve in thyroid surgery. Langenbecks Arch. Surg. 402, 701–708 (2017). https://doi.org/10.1007/s00423-016-1438-8

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Alessandra Cossa.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Informed consent

All of the patients undergoing surgery have signed informed consent.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Cossa, A., Castagnola, G., Romeo, G. et al. Utility of intraoperative neuromonitoring in detecting recurrent nerve’s anatomical anomalies during thyroidectomy. Endocrine 70, 194–197 (2020). https://doi.org/10.1007/s12020-020-02345-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12020-020-02345-x

Keywords

Navigation