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Human heart shifts from IGF-1 production to utilization with chronic heart failure

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  • 29 July 2019

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

References

  1. M. Arcopinto, A. Salzano, E. Bossone, F. Ferrara, E. Bobbio, D. Sirico, O. Vriz, C. De Vincentiis, M. Matarazzo, L. Saldamarco, F. Sacca, R. Napoli, M. Lacoviello, V. Triggiani, A.M. Isidori, C. Vigorito, J. Isgaard, A. Cittadini, Multiple hormone deficiencies in chronic heart failure. Int. J. Cardiol. 184, 421–423 (2015). https://doi.org/10.1016/j.ijcard.2015.02.055

    Article  PubMed  Google Scholar 

  2. A. Salzano, A.M. Marra, F. Ferrara, M. Arcopinto, E. Bobbio, P. Valente, R. Polizzi, C. De Vincentiis, M. Matarazzo, L. Saldamarco, F. Sacca, R. Napoli, M.G. Monti, R. D’Assante, A. Isidori, J. Isgaard, N. Ferrara, P.P. Filardi, F. Perticone, C. Vigorito, E. Bossone, A. Cittadini, T. Investigators, Multiple hormone deficiency syndrome in heart failure with preserved ejection fraction. Int. J. Cardiol. 225, 1–3 (2016). https://doi.org/10.1016/j.ijcard.2016.09.085

    Article  PubMed  Google Scholar 

  3. Arcopinto M., Salzano A., Giallauria F., Bossone E., Isgaard J., Marra A. M., Bobbio E., Vriz O., Aberg D. N., Masarone D., De Paulis A., Saldamarco L., Vigorito C., Formisano P., Niola M., Perticone F., Bonaduce D., Sacca L., Colao A., Cittadini A., Scompen T. T. O. (2017) Growth Hormone Deficiency Is Associated with Worse Cardiac Function, Physical Performance, and Outcome in Chronic Heart Failure: Insights from the TOSCA. GHD Study. PLoS ONE 12 (1). https://doi.org/10.1371/journal.pone.0170058

  4. M. Arcopinto, E. Bobbio, E. Bossone, P. Perrone-Filardi, R. Napoli, L. Sacca, A. Cittadini, The GH/IGF-1 Axis in Chronic Heart Failure. Endocr. Metab. Immune Disord.-Drug Targets 13(1), 76–91 (2013). https://doi.org/10.2174/1871530311313010010

    Article  CAS  PubMed  Google Scholar 

  5. M. Arcopinto, J. Isgaard, A.M. Marra, P. Formisano, E. Bossone, O. Vriz, C. Vigorito, L. Sacca, P.S. Douglas, A. Cittadini, IGF-1 predicts survival in chronic heart failure. Insights from the TOSCA. (Trattamento Ormonale Nello Scompenso CArdiaco) registry. Int. J. Cardiol. 176(3), 1006–1008 (2014). https://doi.org/10.1016/j.ijcard.2014.07.003

    Article  PubMed  Google Scholar 

  6. J. Isgaard, H. Wahlander, M.A. Adams, P. Friberg, Increased expression of growth-hormone receptor m-RNA and insulin-like growth-factor-I m-RNA in volume-overloaded hearts. Hypertension 23(6), 884–888 (1994). https://doi.org/10.1161/01.hyp.23.6.884

    Article  CAS  PubMed  Google Scholar 

  7. P. Ponikowski, A.A. Voors, S.D. Anker, H. Bueno, J.G.F. Cleland, A.J.S. Coats, V. Falk, J.R. Gonzalez-Juanatey, V.P. Harjola, E.A. Jankowska, M. Jessup, C. Linde, P. Nihoyannopoulos, J.T. Parissis, B. Pieske, J.P. Riley, G.M.C. Rosano, L.M. Ruilope, F. Ruschitzka, F.H. Rutten, P. van der Meer, G. Filippatos, J.J.V. McMurray, V. Aboyans, S. Achenbach, S. Agewall, N. Al-Attar, J.J. Atherton, J. Bauersachs, A.J. Camm, S. Carerj, C. Ceconi, A. Coca, P. Elliott, C. Erol, J. Ezekowitz, C. Fernandez-Golfin, D. Fitzsimons, M. Guazzi, 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur. J. Heart Fail. 18(8), 891–975 (2016). https://doi.org/10.1002/ejhf.592

    Article  Google Scholar 

  8. J. Niebauer, C.D. Pflaum, A.L. Clark, C.J. Strasburger, J. Hooper, P.A. Poole-Wilson, A.J.S. Coats, S.D. Anker, Deficient insulin-like growth factor I in chronic heart failure predicts altered body composition, anabolic deficiency, cytokine and neurohormonal activation. J. Am. Coll. Cardiol. 32(2), 393–397 (1998). https://doi.org/10.1016/s0735-1097(98)00226-5

    Article  CAS  PubMed  Google Scholar 

  9. M. Spies, O. Nesic, R.E. Barrow, J.R. Perez-Polo, D.N. Herndon, Liposomal IGF-1 gene transfer modulates pro- and anti-inflammatory cytokine mRNA expression in the burn wound. Gene Ther. 8(18), 1409–1415 (2001). https://doi.org/10.1038/sj.gt.3301543

    Article  CAS  PubMed  Google Scholar 

  10. M. Arcopinto, A. Salzano, J. Isgaard, A. Cittadini, Hormone replacement therapy in heart failure. Curr. Opin. Cardiol. 30(3), 277–284 (2015). https://doi.org/10.1097/hco.0000000000000166

    Article  PubMed  Google Scholar 

  11. E. Bossone, M. Arcopinto, M. Iacoviello, V. Triggiani, F. Cacciatore, C. Maiello, G. Limongelli, D. Masarone, F. Perticone, A. Sciacqua, P. Perrone-Filardi, A. Mancini, M. Volterrani, O. Vriz, R. Castello, A. Passantino, M. Campo, P.A. Modesti, A. De Giorgi, I. Monte, A. Puzzo, A. Ballotta, L. Caliendo, R. D’Assante, A.M. Marra, A. Salzano, T. Suzuki, A. Cittadini, T. Investigators, Multiple hormonal and metabolic deficiency syndrome in chronic heart failure: rationale, design, and demographic characteristics of the TOSCA. Registry. Intern. Emerg. Med. 13(5), 661–671 (2018). https://doi.org/10.1007/s11739-018-1844-8

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

A. Salzano received research grant support from Cardiopath, UniNA and Compagnia di San Paolo, as part of the Programme STAR. AM. Marra was supported by an institutional grant from Italian Healthcare Ministry (Ricerca Finalizzata for young researchers). (Project n. GR-2016-02364727).

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Author notes

  1. These authors contributed equally: Roberta D’Assante, Raffaele Napoli

Authors and Affiliations

  1. Department of Translational Medical Sciences, Unit of Internal Medicine, Metabolism & Rehabilitation, Federico II University of Naples, Via S. Pansini n. 5, Bld. 18, 1st floor, Naples, 80131, Italy

    Roberta D’Assante, Raffaele Napoli, Michele Arcopinto, Giuseppe Perruolo, Pietro Formisano & Antonio Cittadini

  2. Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre, University of Leicester, Glenfield Hospital, Groby Road, Leicester, LE3 9QP, UK

    Andrea Salzano

  3. Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

    Carlotta Pozza

  4. IRCCS SDN, Naples, Italy

    Alberto Maria Marra

  5. Emergency Department, A Cardarelli Hospital, Naples, Italy

    Michele Arcopinto & Lavinia Saldamarco

  6. Department of Laboratory Medicine, CoreLab, AOUP “P. Giaccone”, University of Palermo, Palermo, Italy

    Salvatore Milano

  7. Department of Advanced Biomedical Sciences, Division of Cardiology, Federico II University of Naples, Naples, Italy

    Plinio Cirillo

Authors
  1. Roberta D’Assante
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  2. Raffaele Napoli
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  3. Andrea Salzano
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  4. Carlotta Pozza
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  5. Alberto Maria Marra
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  6. Michele Arcopinto
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  7. Giuseppe Perruolo
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  8. Salvatore Milano
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  9. Pietro Formisano
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  10. Lavinia Saldamarco
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  11. Plinio Cirillo
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  12. Antonio Cittadini
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Corresponding author

Correspondence to Antonio Cittadini.

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The authors declare that they have no conflict of interest.

Ethics approval

The study protocol was conducted according to the Declaration of Helsinki and was approved by the Federico II University Ethics Committee.

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Informed consent was obtained from all subjects included in the study.

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D’Assante, R., Napoli, R., Salzano, A. et al. Human heart shifts from IGF-1 production to utilization with chronic heart failure. Endocrine 65, 714–716 (2019). https://doi.org/10.1007/s12020-019-01993-y

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