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Elevated serum IGF-1 level enhances retinal and choroidal thickness in untreated acromegaly patients

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Abstract

Purpose

1) To compare the retinal, choroidal, Haller’s layer, and Sattler’s/choriocapillaris thicknesses of untreated acromegaly patients without chiasm compression or diabetes mellitus and healthy controls. 2) To evaluate the correlations of retinal and choroidal thicknesses with serum growth hormone (GH) and insulin-like growth factor 1 (IGF) burden.

Methods

This prospective, case-control study included 27 untreated acromegaly patients and 27 sex-matched and age-matched controls. Subfoveal choroidal, Haller’s layer and Sattler’s/choriocapillaris thicknesses were determined by enhanced-depth imaging optical coherence tomography (EDI-OCT). Foveal and macular retinal thicknesses were determined with SD-OCT. GH and IGF-1 burdens were defined as the product of disease duration and treatment-naïve serum GH and IGF-1 levels.

Results

Compared with healthy controls, patients with acromegaly exhibited significantly increased foveal retinal (p = 0.003), subfoveal choroidal (p < 0.001), and Haller’s layer (p < 0.001) thicknesses, with no differences in Sattler’s/choriocapillaris layer thickness. Multiple point measurements in the posterior pole area showed equally increased nasal and temporal parts of the choroid. The retinal thickness maps of the two groups did not significantly differ. Correlation analysis indicated that choroidal thickness was significantly correlated with disease duration (p = 0.01), serum IGF-1 level (p = 0.03) and IGF-1 burden (p = 0.009). No significant correlations were detected between choroidal thickness and GH burden (p = 0.44). Retinal thickness was not significantly correlated with any factor.

Conclusion

The choroidal thickness of acromegaly patients was greater than that of healthy controls and was significantly correlated with disease duration, IGF-1 level and IGF-1 burden, indicating that excessive serum IGF-1 and its exposure time have a combined effect on choroidal thickness.

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Acknowledgements

The authors thank Dr. Erqian Wang for her kind help and advice regarding this article.

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Authors and Affiliations

  1. Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

    Xia Zhang, Jin Ma, Yuhan Wang, Lüe Li & Yong Zhong

  2. Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

    Lu Gao, Xiaopeng Guo & Bing Xing

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  1. Xia Zhang
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  2. Jin Ma
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  3. Yuhan Wang
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  4. Lüe Li
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  6. Xiaopeng Guo
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Correspondence to Bing Xing or Yong Zhong.

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Xia Zhang and Jin Ma contributed equally to this work.

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Zhang, X., Ma, J., Wang, Y. et al. Elevated serum IGF-1 level enhances retinal and choroidal thickness in untreated acromegaly patients. Endocrine 59, 634–642 (2018). https://doi.org/10.1007/s12020-017-1511-2

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  • DOI: https://doi.org/10.1007/s12020-017-1511-2

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