Skip to main content

Advertisement

Log in

Vitamin D Status in the North African Population: a Review

  • Review Paper
  • Published:
Clinical Reviews in Bone and Mineral Metabolism Aims and scope Submit manuscript

Abstract

Even though the North African countries are located in one of the sunniest place in the world, several North African studies from there proved a high prevalence of hypovitaminosis D in men and women. The objectives of the present review are to summarize the existing literature on vitamin D status and to list the main predictors of hypovitaminosis D in North African population. We searched Medline/PubMed, Cochrane, CINAHL, Embase, Scopus, and Springerlink for the published data on vitamin D in North African countries. The identified articles had to meet all the following criteria: human clinical outcomes rather than animal experiments, a cross-sectional or longitudinal study and quantitative information on vitamin D status in North Africa must be included. Several studies proved a high prevalence of hypovitaminosis D in North African men and women. Also, these studies reported that determinants of vitamin D status were the culture of avoiding the sun, the wearing of the veil for women, the pigmented skin, the lack of vitamin D supplementation in the aliments, the breastfeeding for 2 years. This review on vitamin D status in North Africa indicates a high prevalence of vitamin D insufficiency in men and women (among all age groups).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Abbreviations

Vitamin D3:

cholecalciferol

Vitamin D2:

ergocalciferol

Vitamin D:

vitamin D2 or Vitamin D3

DBP:

vitamin D–binding protein

1, 25 (OH)2D:

1,25 dihydroxyvitamin D

GC:

group-specific component

VDBP:

vitamin D–binding protein

RA:

rheumatoid arthritis

BMI:

body mass index

UVB:

ultraviolet B light

Conversion factor:

2.5 nmol/l serum 25OHD = 1 ng/ml serum25OHD

References

  1. Mithal A, Wahl DA, Bonur JP, Burckhardt P, Dawson-Hughes B, Eisman JA, et al. Global vitamin D status and determinants of hypovitaminosis D. Osteoporos Int. 2009;20(11):1807–20. https://doi.org/10.1007/s00198-009-0954-6.

    Article  CAS  PubMed  Google Scholar 

  2. Vanchinathan V, Lim HW. A dermatologist’s perspective on vitamin D. Mayo Clin Proc. 2012;87(4):372–80. https://doi.org/10.1016/j.mayocp.2011.12.010.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Kuchuk NO, van Schoor NM, Pluijm SM, Chines A, Lips P. Vitamin D status, parathyroid function, bone turnover, and BMD in postmenopausal women with osteoporosis: global perspective. J Bone Miner Res. 2009;24(4):693–701. https://doi.org/10.1359/jbmr.081209.

    Article  CAS  PubMed  Google Scholar 

  4. Jacques PF, Felson DT, Tucker KL, Mahnken B, Wilson PW, Rosenberg IH, et al. Plasma 25-hydroxyvitamin D and its determinants in an elderly population sample. Am J Clin Nutr. 1997;66(4):929–36.

    Article  CAS  PubMed  Google Scholar 

  5. Prentice A. Vitamin D deficiency: a global perspective. Nutr Rev. 2008;66(10 Suppl 2):S153–64. https://doi.org/10.1111/j.1753-4887.2008.00100.x.

    Article  PubMed  Google Scholar 

  6. Holick MF, MacLaughlin JA, Doppelt SH. Regulation of cutaneous previtamin D3 photosynthesis in man: skin pigment is not an essential regulator. Science. 1981;211(4482):590–3.

    Article  CAS  PubMed  Google Scholar 

  7. Ragab WS, Saleh WF, Tawfik LT. Vitamin D deficiency in postmenopausal Egyptian women. Int J Gynaecol Obstet. 2013;123(1):75–6. https://doi.org/10.1016/j.ijgo.2013.04.016.

    Article  CAS  PubMed  Google Scholar 

  8. Botros RM, Sabry IM, Abdelbaky RS, Eid YM, Nasr MS, Hendawy LM. Vitamin D deficiency among healthy Egyptian females. Endocrinol Nutr. 2015;62(7):314–21. https://doi.org/10.1016/j.endonu.2015.03.010.

    Article  PubMed  Google Scholar 

  9. Ghoneim AH, Al-Azzawi MA, Elmasry SA, Nasr MY, AboZaid MMN. Association of vitamin D status in the pathogenesis of chronic obstructive pulmonary disease. Egypt J Chest DisTuberc. 2015;64(4):805–12.

    Article  Google Scholar 

  10. Elbassiony SR, Tawhid Z, Ahmad HS, Sabry A. Serum 25-hydroxy vitamin D levels in Egyptian patients with rheumatoid arthritis: association with disease activity, functional disability and radiological damage. The Egyptian Rheumatologist.

  11. Meddeb N, Sahli H, Chahed M, Abdelmoula J, Feki M, Salah H, et al. Vitamin D deficiency in Tunisia. Osteoporos Int. 2005;16(2):180–3.

    Article  CAS  PubMed  Google Scholar 

  12. Sghaier-Ayadi A, Feki M, Ayed IB, Abene O, Fredj MB, Kaabachi K, et al. Vitamin D status and determinants of deficiency in non-supplemented athletes during the winter months in Tunisia. Biol Sport. 2015;32(4):281–7. https://doi.org/10.5604/20831862.1163690.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Elzouki AY, Markestad T, Elgarrah M, Elhoni N, Aksnes L. Serum concentrations of vitamin D metabolites in rachitic Libyan children. J Pediatr Gastroenterol Nutr. 1989;9(4):507–12.

    Article  CAS  PubMed  Google Scholar 

  14. Djennane M, Lebbah S, Roux C, Djoudi H, Cavalier E, Souberbielle JC. Vitamin D status of schoolchildren in Northern Algeria, seasonal variations and determinants of vitamin D deficiency. Osteoporos Int. 2014;25(5):1493–502. https://doi.org/10.1007/s00198-014-2623-7.

    Article  CAS  PubMed  Google Scholar 

  15. El Maataoui A, El Maghraoui A, Biaz A, Elmachtani SI, Dami A, Bouhsain S, et al. Relationships between vertebral fractures, sex hormones and vitamin D in Moroccan postmenopausal women: a cross sectional study. BMC Womens Health. 2015;15:41. https://doi.org/10.1186/s12905-015-0199-9.

    Article  CAS  PubMed  Google Scholar 

  16. Elmaataoui A, Elmachtani Idrissi S, Dami A, Bouhsain S, Chabraoui L, Ouzzif Z. Association entre les marqueurs du remodelage osseux, la densité minérale osseuse et le statut vitaminique D chez des femmes ménopausées d’origine marocaine. Pathol Biol. 2014;62(1):49–54.

    Article  CAS  PubMed  Google Scholar 

  17. Allali F, El Aichaoui S, Khazani H, Benyahia B, Saoud B, El Kabbaj S, et al. High prevalence of hypovitaminosis D in Morocco: relationship to lifestyle, physical performance, bone markers, and bone mineral density. Semin Arthritis Rheum. 2009;38(6):444–51. https://doi.org/10.1016/j.semarthrit.2008.01.009.

    Article  CAS  PubMed  Google Scholar 

  18. Safi S, Ouleghzal H, Khaldouni I, Hassikou H, Ballouch L, Bamou Y, et al. Statut de la vitamine D chez les patients diabétiques de type 2 marocains. Médecine des Maladies Métaboliques. 2015;9(1):67–72.

    Article  Google Scholar 

  19. Norman AW. From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health. Am J Clin Nutr. 2008;88(2):491S–9S.

    Article  CAS  PubMed  Google Scholar 

  20. Dixon KM, Sequeira VB, Camp AJ, Mason RS. Vitamin D-fence. Photochem Photobiol Sci. 2010;9(4):564–70. https://doi.org/10.1039/b9pp00184k.

    Article  CAS  PubMed  Google Scholar 

  21. van Schoor NM, Lips P. Worldwide vitamin D status. Best Pract Res Clin Endocrinol Metab. 2011;25(4):671–80. https://doi.org/10.1016/j.beem.2011.06.007.

    Article  CAS  PubMed  Google Scholar 

  22. Knudsen VK, Rasmussen LB, Haraldsdóttir J, Ovesen L, Bülow I, Knudsen N, et al. Use of dietary supplements in Denmark is associated with health and former smoking. Public Health Nutr. 2002;5(3):463–8.

    Article  PubMed  Google Scholar 

  23. Cashman KD, Muldowney S, McNulty B, Nugent A, FitzGerald AP, Kiely M, et al. Vitamin D status of Irish adults: findings from the National Adult Nutrition Survey. Br J Nutr. 2013;109(7):1248–56. https://doi.org/10.1017/S0007114512003212.

    Article  CAS  PubMed  Google Scholar 

  24. Rockell JE, Green TJ, Skeaff CM, Whiting SJ, Taylor RW, Williams SM, et al. Season and ethnicity are determinants of serum 25-hydroxyvitamin D concentrations in New Zealand children aged 5-14 y. J Nutr. 2005;135(11):2602–8.

    Article  CAS  PubMed  Google Scholar 

  25. Powe CE, Evans MK, Wenger J, Zonderman AB, Berg AH, Nalls M, et al. Vitamin D-binding protein and vitamin D status of black Americans and white Americans. N Engl J Med. 2013;369(21):1991–2000. https://doi.org/10.1056/NEJMoa1306357.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Bouillon R (2011)Chapter 5—The Vitamin D Binding Protein DBP A2 - Feldman, David. In: Pike JW, Adams JS (eds) Vitamin D (Third Edition). Academic Press, San Diego, pp 57–72. doi:https://doi.org/10.1016/B978-0-12-381978-9.10005-8.

    Chapter  Google Scholar 

  27. Denburg MR, Hoofnagle AN, Sayed S, Gupta J, de Boer IH, Appel LJ, et al. Comparison of two ELISA methods and mass spectrometry for measurement of vitamin D-binding protein: implications for the assessment of bioavailable vitamin D concentrations across genotypes. J Bone Miner Res. 2016;31(6):1128–36. https://doi.org/10.1002/jbmr.2829.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Candido FG, Bressan J. Vitamin D: link between osteoporosis, obesity, and diabetes? Int J Mol Sci. 2014;15(4):6569–91. https://doi.org/10.3390/ijms15046569.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Powe CE, Ricciardi C, Berg AH, Erdenesanaa D, Collerone G, Ankers E, et al. Vitamin D-binding protein modifies the vitamin D-bone mineral density relationship. J Bone Miner Res. 2011;26(7):1609–16. https://doi.org/10.1002/jbmr.387.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Oussedik-Lehtihet S, Haouichat C, Hammoumraoui N, Ducros E, Gouhier-Kodas C, Lancrenon S, Djoudi H. Hypovitaminosis D and its associated factors in North Algerian postmenopausal women: results of a cross-sectional study .J Nutr Metab Volume 2017 (2017), Article ID 9032141, 8 pages. doi: https://doi.org/10.1155/2017/9032141, 1.

    Article  Google Scholar 

  31. El Maghraoui A, Ouzzif Z, Mounach A, Rezqi A, Achemlal L, Bezza A, Tellal S,Dehhaoui M, Ghozlani I (2012) Hypovitaminosis D and prevalent asymptomatic vertebral fractures in Moroccan postmenopausal women. BMC Womens Health 24(12):11.

  32. El Maataoui A, Benghabrite A, El Maghraoui A, Chabraoui L, Ouzzif Z. Relationship between sex hormone levels, bone mineral density and bone turnover markers in healthy moroccan men: a cross-sectional study. Pan Afr Med J. 2015;22

Download references

Author information

Authors and Affiliations

Authors

Contributions

Aissam El maataoui wrote the manuscript. All authors contributed equally in the literature search, interpretation of the articles, and review of the manuscript. All the authors have read and approved the final version of the manuscript.

Corresponding author

Correspondence to Aissam El Maataoui.

Ethics declarations

Conflict of Interests

The authors declare that they have no conflict of interest.

Ethical Approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

El Maataoui, A., Ouzzif, Z. Vitamin D Status in the North African Population: a Review. Clinic Rev Bone Miner Metab 16, 67–73 (2018). https://doi.org/10.1007/s12018-018-9247-y

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12018-018-9247-y

Keywords

Navigation