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A Fully-Closed and Automated Hollow Fiber Bioreactor for Clinical-Grade Manufacturing of Human Mesenchymal Stem/Stromal Cells

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References

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Acknowledgements

This work was supported by FAPESP (2012/23228-4), CTC- Center for Cell-based Therapies (FAPESP 2013/08135-2) and National Institute of Science and Technology in Stem Cell and Cell Therapy (CNPq 573754-2008-0 and FAPESP 2008/578773). The authors acknowledge Fundação para a Ciência e a Tecnologia (FCT), Portugal, through iBB – Institute for Bioengineering and Biosciences under the project UID/BIO/04565/ 2013 and Programa Operacional Regional de Lisboa 2020 (project no. 007317) and grant SFRH/BD/90081/2012 (awarded to FM). We also acknowledge the funding received from Programa Operacional Regional de Lisboa 2020 through the project PRECISE - Accelerating progress toward the new era of precision medicine (Project N. 16394).

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Authors and Affiliations

  1. Center for Cell-based Therapy, Regional Blood Center of Ribeirão Preto, University of São Paulo, Ribeirão Preto-SP, Brazil

    Amanda Mizukami, Mario Soares de Abreu Neto, Dimas T. Covas & Kamilla Swiech

  2. Department of Bioengineering and IBB-Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal

    Francisco Moreira, Ana Fernandes-Platzgummer, Joaquim M. S. Cabral & Cláudia L. da Silva

  3. The Discoveries Centre for Regenerative and Precision Medicine, Lisbon Campus, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal

    Ana Fernandes-Platzgummer, Joaquim M. S. Cabral & Cláudia L. da Silva

  4. R&D, AventaCell BioMedical Corp., Ltd., New Taipei City, Taiwan, Republic of China

    Yi-Feng Huang & William Milligan

  5. R&D, AventaCell BioMedical Corp., Ltd., Atlanta, GA, USA

    William Milligan

  6. Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo., Av. do Café s/n, 14040-903, Ribeirão Preto, SP, Brazil

    Kamilla Swiech

Authors
  1. Amanda Mizukami
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  2. Mario Soares de Abreu Neto
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  3. Francisco Moreira
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  4. Ana Fernandes-Platzgummer
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  5. Yi-Feng Huang
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  6. William Milligan
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  7. Joaquim M. S. Cabral
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  8. Cláudia L. da Silva
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  9. Dimas T. Covas
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  10. Kamilla Swiech
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Corresponding author

Correspondence to Kamilla Swiech.

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Ethical Approval

All procedures performed with human samples were in accordance with the ethical standards of the institutional and/or national research committee.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

Disclosure of Potential Conflict of Interest

The authors have declared that there is no conflict of interest.

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Mizukami, A., de Abreu Neto, M.S., Moreira, F. et al. A Fully-Closed and Automated Hollow Fiber Bioreactor for Clinical-Grade Manufacturing of Human Mesenchymal Stem/Stromal Cells. Stem Cell Rev and Rep 14, 141–143 (2018). https://doi.org/10.1007/s12015-017-9787-4

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  • DOI: https://doi.org/10.1007/s12015-017-9787-4

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