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Matrix Metalloproteinase-1 (MMP1) Polymorphism is Associated with Lowered Risk of Nasopharyngeal Carcinoma in Asian Population

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Abstract

Data on the association between −1607 1G > 2G polymorphism in the promoter region of matrix metalloproteinase-1 (MMP1) and nasopharyngeal carcinoma (NPC) are conflicting. The aim of this study was to confirm whether this polymorphism was a causative factor of NPC. We searched PubMed, Embase, and China National Knowledge Infrastructure (CNKI) for studies on the present topic. A total of four publications (1,044 NPC patients and 1,284 healthy control subjects) were included and meta-analysis was performed to assess the association between −1607 1G > 2G polymorphism and NPC risk. Odds ratio (OR) with 95 % confidence interval (95 % CI) was calculated for 1G1G versus 2G2G, 1G1G + 1G2G versus 2G2G, 1G1G versus 1G2G + 2G2G, 1G versus 2G, and 1G2G versus 2G2G contrast models. Meta-analysis results showed significantly reduced risk of NPC associated with the 1G1G versus 2G2G, 1G versus 2G and 1G2G versus 2G2G contrast models (OR = 0.61, 95 % CI 0.49–0.77; OR = 0.78, 95 % CI 0.65–0.92; OR = 0.86, 95 % CI 0.74–0.99, respectively). When we continued to perform subgroup analysis by ethnicity, the significant association persisted in Asian population and was most pronounced under the 1G2G versus 2G2G model (OR = 0.85, 95 % CI 0.73–0.99). These data suggested that MMP1 −1607 1G > 2G polymorphism was associated with reduced risk of NPC, particularly in the population of Asian descent.

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Conflict of interest

The authors have not declared any conflict of interest.

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Authors and Affiliations

  1. Department of Otorhinolaryngology, Yantaishan Hospital Affiliated to Medical College of Taishan, 91 Jiefang Road, Yantai, 264000, Shandong, China

    Zhen Li & Chao Lv

  2. Department of Otorhinolaryngology, Laixi People Hospital, 69 Yantai Road, Laixi, 266600, China

    Hongzhou Ge

  3. Department of Anesthesiology, Yuhuangding Hospital Affiliated to Medical College of Qingdao University, 20 Yuhuangding East Road, Yantai, 264000, China

    Yong-Gang Xie

  4. Department of Clinical Laboratory, QiXia Renmin Hospital Affiliated to Medical College of Binzhou, 259 Minsheng Road, Qixia, 265300, China

    Guang-Ying Xie

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  1. Zhen Li
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  2. Hongzhou Ge
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  3. Yong-Gang Xie
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  4. Guang-Ying Xie
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  5. Chao Lv
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Correspondence to Chao Lv.

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Zhen Li and Hongzhou Ge have contributed equally to this manuscript.

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Li, Z., Ge, H., Xie, YG. et al. Matrix Metalloproteinase-1 (MMP1) Polymorphism is Associated with Lowered Risk of Nasopharyngeal Carcinoma in Asian Population. Cell Biochem Biophys 71, 999–1004 (2015). https://doi.org/10.1007/s12013-014-0299-4

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  • DOI: https://doi.org/10.1007/s12013-014-0299-4

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