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Real-Time and Online Monitoring of Glucose Contents by Using Molecular Imprinted Polymer-Based IDEs Sensor

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Abstract

A highly sensitive, selective, reversible, and reusable glucose sensor is developed by using molecularly imprinted polymer-based artificial receptors onto interdigital transducer. Sensor receptors were synthesized through bulk imprinting technology by using styrene as monomer, ethylene glycol dimethacrylate (EGDMA) as cross-linker, and AIBN as free radical initiator. Topography of the synthesized receptors was investigated by scanning electron microscopy (SEM). Fabricated sensor showed concentration-dependent linear and reversible response with lower limit of detection of 30 ppb and upper limit of detection ~ 500 ppm. Furthermore, newly fabricated sensor is highly selective towards its analyte of interest in the presence of other competing agents, and the regeneration of sensor response has been assessed with the percentage error of less than 2% under the period of 1 year at room temperature and pressure conditions. The reported sensor may have potential technological applications in the field of medical diagnostics, food, and pharmaceutical industry.

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Acknowledgments

Authors are thankful to Higher Education Commission of Pakistan, School of Materials Science and Engineering, University of Jinan (West Campus) Jinan, China and the Department of Chemistry, Al al-Bayt University Al-Mafraq, Jordan for their support in material testing.

Funding Statement

This work was supported financially by Higher Education Commission Pakistan, International Islamic University, Islamabad, Pakistan and OeAD Austria.

Data Availability Statement

The data used to support the findings of this study are included within the article.

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Authors and Affiliations

  1. Sulaiman Bin Abdullah Aba Al-Khail Centre for Interdisciplinary Research in Basic Sciences (SA-CIRBS) Faculty of Basic and Applied Sciences, International Islamic University, H-10, Islamabad, 44000, Pakistan

    Nazia Asghar, Ghulam Mustafa & Maimoona Yasinzai

  2. Department of Physical Chemistry, University of Vienna, Weahringer Strasse 38, 1090, Vienna, Austria

    Ghulam Mustafa & Peter A. Lieberzeit

  3. Department of Chemistry, Faculty of Science, Al al-Bayt University, Al-Mafraq, Jordan

    Yaseen A. Al-Soud

  4. Interdisciplinary Research Centre in Biomedical Materials, COMSATS University Islamabad, Lahore Campus, Lahore, 54600, Pakistan

    Usman Latif

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  1. Nazia Asghar
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  2. Ghulam Mustafa
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  3. Maimoona Yasinzai
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  4. Yaseen A. Al-Soud
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  5. Peter A. Lieberzeit
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Correspondence to Ghulam Mustafa or Usman Latif.

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Asghar, N., Mustafa, G., Yasinzai, M. et al. Real-Time and Online Monitoring of Glucose Contents by Using Molecular Imprinted Polymer-Based IDEs Sensor. Appl Biochem Biotechnol 189, 1156–1166 (2019). https://doi.org/10.1007/s12010-019-03049-3

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