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Possible Role of Dysbiosis of the Gut Microbiome in SLE

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Abstract

Purpose of Review

The resident gut microbiota serves as a double-edged sword that aids the host in multiple ways to preserve a healthy equilibrium and serve as early companions and boosters for the gradual evolution of our immune defensive layers; nevertheless, the perturbation of the symbiotic resident intestinal communities has a profound impact on autoimmunity induction, particularly in systemic lupus erythematosus (SLE). Herein, we seek to critically evaluate the microbiome research in SLE with a focus on intestinal dysbiosis.

Recent Findings

SLE is a complex and heterogeneous disorder with self-attack due to loss of tolerance, and there is aberrant excessive immune system activation. There is mounting evidence suggesting that intestinal flora disturbances may accelerate the formation and progression of SLE, presumably through a variety of mechanisms, including intestinal barrier dysfunction and leaky gut, molecular mimicry, bystander activation, epitope spreading, gender bias, and biofilms.

Summary

Gut microbiome plays a critical role in SLE pathogenesis, and additional studies are warranted to properly define the impact of gut microbiome in SLE, which can eventually lead to new and potentially safer management approaches for this debilitating disease.

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  1. Faculty of Medicine, Hacettepe University, Ankara, Turkey

    F. Naz Cemre Kalayci

  2. Department of Paediatric Rheumatology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

    Seza Ozen

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Kalayci, F.N.C., Ozen, S. Possible Role of Dysbiosis of the Gut Microbiome in SLE. Curr Rheumatol Rep 25, 247–258 (2023). https://doi.org/10.1007/s11926-023-01115-8

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