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Recent Progress in Pharmacogenomics of Antipsychotic Drug Response

  • Genetic Disorders (F Goes, Section Editor)
  • Published:
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Abstract

Purpose of Review

Pharmacogenomics (PGx) of antipsychotic drug response is an active area of research in the past few years. We reviewed recent PGx studies with an emphasis of development of new methodologies and new research directions.

Recent Findings

Traditional candidate gene approach continues to generate evidence to support the associations of antipsychotic response with genes coding for drug targets such as DRD2. Genome-wide association studies have found a few novel genes that may be associated with drug efficacy and adverse events. Recent application of polygenic risk score makes it possible to combine many genetic variants to predict clinical response. Finally, epigenetic research including DNA methylation is emerging and promises new findings that potentially can be applied in clinical practice.

Summary

New methodologies may advance PGx closer to clinical application. Multiple genes and epigenomic markers can be used in prediction of clinical phenotypes.

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Authors and Affiliations

  1. Department of Psychiatry, Hofstra Northwell School of Medicine, Hempstead, NY, USA

    Jian-Ping Zhang & Anil K. Malhotra

  2. Division of Psychiatry Research, Zucker Hillside Hospital, Northwell Health, 75-59 263rd Street, Glen Oaks, NY, 11004, USA

    Jian-Ping Zhang & Anil K. Malhotra

  3. Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, NY, USA

    Jian-Ping Zhang & Anil K. Malhotra

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Jian-Ping Zhang declares no conflict of interest.

Anil K. Malhotra has received consultancy fees from Genomind, Inc., Concert Pharma, and Biogen. Dr. Malhotra is an advisory board member and receives stock options from InformedDNA.

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Zhang, JP., Malhotra, A.K. Recent Progress in Pharmacogenomics of Antipsychotic Drug Response. Curr Psychiatry Rep 20, 24 (2018). https://doi.org/10.1007/s11920-018-0886-y

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