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The genetics of depression in childhood and adolescence

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Abstract

This article reviews family, twin, and adoption studies of childhood and adolescent depression. Results from several family and twin studies suggest that an etiologic heterogeneity exists in depression in childhood and adolescence. Twin studies show that genetic influences on depression in young people may be indirect and work via effects on environmental risk exposure (gene-environment correlation) or genetic sensitivity to environmental risks (gene-environment interaction). Recent research on gene-environment interaction has examined the effect of specific functional genetic polymorphisms in conjunction with environmental stressors. Future research needs to work toward identifying which environmental and genetic risk factors are crucial to the development of depression in youth, as well as mechanisms involved in the familial transmission of depression. This will not only improve understanding of the etiology of childhood and adolescent depression but also inform the development of therapeutic and preventive interventions.

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References and Recommended Reading

  1. Birmaher B, Ryan ND, Williamson DE, et al.: Childhood and adolescent depression: a review of the past 10 years. Part I. J Am Acad Child Adolesc Psychiatry 1996, 35:1427–1439.

    Article  PubMed  CAS  Google Scholar 

  2. Harrington R: Affective disorders. In Child and Adolescent Psychiatry: Modern Approaches. Edited by Rutter M, Taylor E, Hersov L. Oxford: Blackwell Science; 1994:330–345.

    Google Scholar 

  3. Meltzer H, Gatward R, Ford T: Mental Health of Children and Adolescents in Great Britain. London: The Stationery Office; 2000.

    Google Scholar 

  4. Angold A, Erkanli A, Silberg J, et al.: Depression scale scores in 8–17 year olds: effects of age and gender. J Child Psychol Psychiatry 2002, 43:1052–1063.

    Article  PubMed  Google Scholar 

  5. Angold A, Costello EJ, Farmer EM, et al.: Impaired but undiagnosed. J Am Acad Child Adolesc Psychiatry 1999, 38:129–137.

    Article  PubMed  CAS  Google Scholar 

  6. Lewinsohn PM, Solomon A, Seeley JR, Zeiss A: Clinical implications of ’subthreshold’; depressive symptoms. J Abnorm Psychol 2002, 109:345–351.

    Article  Google Scholar 

  7. Johnson J, Weissman MM, Klerman GL: Service utilization and social morbidity associated with depressive symptoms in the community. JAMA 1992, 267:1478–1483.

    Article  PubMed  CAS  Google Scholar 

  8. Dunn V, Goodyer I: Longitudinal investigation into childhood and adolescence onset depression: psychiatric outcome in early adulthood. Br J Psychiatry 2006, 188:216–222.

    Article  PubMed  Google Scholar 

  9. Pine DS, Cohen E, Cohen P, Brook J: Adolescent depressive symptoms as predictors of adult depression: moodiness or mood disorder? Am J Psychiatry 1999, 156:133–135.

    PubMed  CAS  Google Scholar 

  10. Harrington R, Rutter M, Weissman M, et al.: Psychiatric disorders in the relatives of depressed probands. I. Comparison of prepubertal, adolescent and early adult onset cases. J Affect Disord 1997, 42:9–22.

    Article  PubMed  CAS  Google Scholar 

  11. Klein DN, Lewinsohn PM, Seeley JR, Rohde P: A family study of major depressive disorder in a community sample of adolescents. Arch Gen Psychiatry 2001, 58:13–22.

    Article  PubMed  CAS  Google Scholar 

  12. Rice F, Harold G, Thapar A: The genetic etiology of childhood depression: a review. J Child Psychol Psychiatry 2002, 43:65–79.

    Article  PubMed  Google Scholar 

  13. Downey G, Coyne JC: Children of depressed parents: an integrative review. Psychol Bull 1990, 108:50–76.

    Article  PubMed  CAS  Google Scholar 

  14. Goodman S, Gotlib I: Risk for psychopathology in the children of depressed mothers: a developmental model for understanding mechanisms of transmission. Psychol Rev 1999, 106:458–490.

    Article  PubMed  CAS  Google Scholar 

  15. Amato PR, Keith B: Parental divorce and the well-being of children-a meta analysis. Psychol Bull 1991, 110:26–46.

    Article  PubMed  CAS  Google Scholar 

  16. Weissman MM, Wickramaratne P, Merikangas KR, et al.: Onset of major depression in early adulthood. Increased familial loading and specificity. Arch Gen Psychiatry 1984, 41:1136–1143.

    PubMed  CAS  Google Scholar 

  17. Wickramaratne PJ, Warner V, Weissman MM: Selecting early onset MDD probands for genetic studies: results from a longitudinal high-risk study. Am J Med Genet 2000, 96:93–101.

    Article  PubMed  CAS  Google Scholar 

  18. Weissman MM, Wolk S, Wickramaratne P, et al.: Prepubertally depressed and anxious children grown up. Arch Gen Psychiatry 1999, 56:794–801.

    Article  PubMed  CAS  Google Scholar 

  19. Sullivan P, Neale MC, Kendler KS: Genetic epidemiology of major depression: review and meta-analysis. Am J Psychiatry 2000, 157:1552–1562.

    Article  PubMed  CAS  Google Scholar 

  20. Harrington R, Fudge H, Rutter M, et al.: Adult outcomes of childhood and adolescent depression. I. Psychiatric status. Arch Gen Psychiatry 1990, 47:465–473.

    PubMed  CAS  Google Scholar 

  21. Jaffee SR, Moffitt TE, Caspi A, et al.: Differences in early childhood risk factors for juvenile-onset and adult-onset depression. Arch Gen Psychiatry 2002, 59:215–222.

    Article  PubMed  Google Scholar 

  22. Kim Cohen J, Moffitt TE, Taylor A, et al.: Maternal depression and children’s antisocial behavior: nature and nurture effects. Arch Gen Psychiatry 2005, 62:173–181.

    Article  PubMed  Google Scholar 

  23. Weissman MM, Pilowsky DJ, Wickramaratne PJ, et al.: Remissions in maternal depression and child psychopathology—a STAR *D child report. JAMA 2006, 295:1389–1398.

    Article  PubMed  CAS  Google Scholar 

  24. Gunlicks ML, Weissman MM: Change in child psychopathology with improvement in parental depression: a systematic review. J Am Acad Child Adolesc Psychiatry 2008, 47:379–389.

    Article  PubMed  Google Scholar 

  25. Glowinski AL, Madden PA, Bucholz KK, et al.: Genetic epidemiology of self-reported lifetime DSM-IV major depressive disorder in a population-based twin sample of female adolescents. J Child Psychol Psychiatry 2003, 44:988–996.

    Article  PubMed  Google Scholar 

  26. Eaves L, Silberg J, Meyer JM, et al.: Genetics and developmental psychopathology: 2. The main effects of genetics and environment of behavioral problems in the Virginia twin study of adolescent behavioral development. J Child Psychol Psychiatry 1997, 38:965–980.

    Article  PubMed  CAS  Google Scholar 

  27. Silberg J, Pickles A, Rutter M, et al.: The influence of genetic factors and life stress on depression among adolescent girls. Arch Gen Psychiatry 1999, 56:225–232.

    Article  PubMed  CAS  Google Scholar 

  28. Eley TC, Stevenson J: Exploring the covariation between anxiety and depression. J Child Psychol Psychiatry 1999, 40:1273–1282.

    Article  PubMed  CAS  Google Scholar 

  29. Rice F, Harold GT, Thapar A: Assessing the effects of age, sex and shared environment on the genetic etiology of depression in childhood and adolescence. J Child Psychol Psychiatry 2002, 43:1039–1051.

    Article  PubMed  Google Scholar 

  30. Rice F, Thapar A: Depression and anxiety in childhood and adolescence: developmental pathways, genes and environment. In Handbook of Behavior Genetics. Edited by Kim YK. New York: Springer; 2009:377–394.

    Google Scholar 

  31. Rice F, Harold GT, Thapar A: Negative life events as an account of the age related differences in the etiology of depression in childhood and adolescence. J Child Psychol Psychiatry 2003, 44:977–987.

    Article  PubMed  Google Scholar 

  32. van den Oord E, Boomsma DI, Verhulst FC: A study of problem behaviors in 10 to 15 year old biologically related and unrelated international adoptees. Behav Genet 1994, 24:193–205.

    Article  PubMed  Google Scholar 

  33. Eley TC, Deater-Deckard K, Fombonne E, et al.: An adoption study of depressive symptoms in middle childhood. J Child Psychol Psychiatry 1998, 39:337–345.

    Article  PubMed  CAS  Google Scholar 

  34. Tully EC, Iacono WG, McGue M: An adoption study of parental depression as an environmental liability for adolescent depression and childhood disruptive disorders. Am J Psychiatry 2008, 165:1148–1154.

    Article  PubMed  Google Scholar 

  35. Jaffee SR, Price T: Gene-environment correlations: a review of the evidence and implications for prevention of mental illness. Mol Psychiatry 2007, 12:432–442.

    PubMed  CAS  Google Scholar 

  36. Plomin R, DeFries JC, McClearn GE, McGuffin P: Behavioral Genetics, edn 5. New York: Worth Publishing; 2008:305–333.

    Google Scholar 

  37. Eaves L, Silberg J, Erkanli A: Resolving multiple epigenetic pathways to adolescent depression. J Child Psychol Psychiatry 2003, 44:1006–1014.

    Article  PubMed  Google Scholar 

  38. Thapar A, Harold GT, McGuffin P: Life events and depressive symptoms in childhood-shared genets of shared adversity? A research note. J Child Psychol Psychiatry 1998, 39:1153–1158.

    Article  PubMed  CAS  Google Scholar 

  39. Neiderheiser JM, Reiss D, Hetherington EM, Plomin R: Relationships between parenting and adolescent adjustment over time: genetic and environmental contributions. Dev Psychol 1999, 35:680–692.

    Article  Google Scholar 

  40. Lau J, Eley TC: Disentangling gene-environment correlations and interactions on adolescent depressive symptoms. J Child Psychol Psychiatry 2008, 49:142–150.

    PubMed  Google Scholar 

  41. Moffitt TE, Caspi A, Rutter M: Strategy for investigating interactions between measured genes and measured environments. Arch Gen Psychiatry 2005, 62:473–481.

    Article  PubMed  CAS  Google Scholar 

  42. Rutter M, Moffitt TE, Caspi A: Gene-environment interplay and psychopathology: multiple varieties but real effects. J Child Psychol Psychiatry 2006, 47:226–261.

    Article  PubMed  Google Scholar 

  43. Silberg J, Rutter M, Neale M, Eaves L: Genetic moderation of environmental risk for depression and anxiety in adolescent girls. Br J Psychiatry 2001, 179:116–121.

    Article  PubMed  CAS  Google Scholar 

  44. Rice F, Harold GT, Shelton KH, Thapar A: Family conflict interacts with genetic liability in predicting childhood and adolescent depression. J Am Acad Child Adolesc Psychiatry 2006, 45:841–848.

    Article  PubMed  Google Scholar 

  45. Zimmermann P, Brückl L, Lieb R, et al.: The interplay of familial depression liability and adverse events in predicting the first onset of depression during a 10-year follow-up. Biol Psychiatry 2008, 63:406–414.

    Article  PubMed  Google Scholar 

  46. Eley TC, Sugden K, Corsico A, et al.: Gene-environment interaction analysis of serotonin system markers with adolescent depression. Mol Psychiatry 2004, 9:908–915.

    Article  PubMed  CAS  Google Scholar 

  47. Kaufman J, Yang BZ, Douglas-Palumberi H, et al.: Social supports and serotonin transporter gene moderate depression in maltreated children. Proc Natl Acad Sci U S A 2004, 101:17316–17321.

    Article  PubMed  CAS  Google Scholar 

  48. Kaufman J, Yang BZ, Douglas-Palumberi H, et al.: Brain-derived neurotrophic factor 5HTTLPR gene interactions and environmental modifiers of depression in children. Biol Psychiatry 2006, 59:673–680.

    Article  PubMed  CAS  Google Scholar 

  49. Garber J: Depression in children and adolescents—linking risk research and prevention. Am J Prev Med 2006, 31:S104–S125.

    Article  PubMed  Google Scholar 

  50. Costello EJ, Compton SN, Keeler G, Angold A: Relationships between poverty and psychopathology—a natural experiment. JAMA 2003, 290:2023–2029.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Clinical, Educational, and Health Psychology Research Department, Division of Psychology and Language Sciences, University College London, 26 Bedford Way, London, WC1H 0AP, UK

    Frances Rice

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  1. Frances Rice
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Correspondence to Frances Rice.

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Rice, F. The genetics of depression in childhood and adolescence. Curr Psychiatry Rep 11, 167–173 (2009). https://doi.org/10.1007/s11920-009-0026-9

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  • DOI: https://doi.org/10.1007/s11920-009-0026-9

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