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Understanding Early-Stage Posttraumatic Osteoarthritis for Future Prospects of Diagnosis: from Knee to Temporomandibular Joint

  • Craniofacial Skeleton (TG Chu and S Akintoye, Section Editors)
  • Published:
Current Osteoporosis Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Many mechanical load-bearing joints of the body are prone to posttraumatic osteoarthritis (PTOA), including the knee joint and temporomandibular joint (TMJ). Early detection of PTOA can be beneficial in prevention or alleviating further progression of the disease.

Recent Findings

Various mouse models, similar to those used in development of novel diagnosis strategies for early stages of OA, have been proposed to study early PTOA. While many studies have focused on OA and PTOA in the knee joint, early diagnostic methods for OA and PTOA of the TMJ are still not well established. Previously, we showed that fluorescent near-infrared imaging can diagnose inflammation and cartilage damage in mouse models of knee PTOA. Here we propose that the same approach can be used for early diagnosis of TMJ-PTOA.

Summary

In this review, we present a brief overview of PTOA, application of relevant mouse models, current imaging methods available to examine TMJ-PTOA, and the prospects of near-infrared optical imaging to diagnose early-stage TMJ-OA.

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Funding

H.C. was supported by grants from Arthritis Foundation (Discovery Award), and Oxnard Foundation (Medical Research Award).

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Authors and Affiliations

  1. Department of Orthopaedic Surgery and Biomedical Engineering, University of Tennessee Health Science Center, Research 151, VAMC, 1030 Jefferson Ave, Memphis, TN, 38104 , USA

    Fazal-Ur-Rehman Bhatti, Anastasios Karydis & Hongsik Cho

  2. Department of Physiology and Cell Biology, College of Medicine, The Ohio State University , Graves Hall, 333 West 10th Avenue, Columbus, OH, 43210, USA

    Beth S. Lee

  3. Division of Orthodontics, College of Dentistry, The Ohio State University, 4088 Postle Hall, 305 W. 12th Ave., Columbus, OH, 43210, USA

    Toru Deguchi & Do-Gyoon Kim

  4. Campbell Clinic, Memphis, TN, USA

    Hongsik Cho

  5. Veterans Affairs Medical Center, Memphis, TN, USA

    Hongsik Cho

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  1. Fazal-Ur-Rehman Bhatti
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  3. Beth S. Lee
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Correspondence to Do-Gyoon Kim or Hongsik Cho.

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Bhatti, FUR., Karydis, A., Lee, B.S. et al. Understanding Early-Stage Posttraumatic Osteoarthritis for Future Prospects of Diagnosis: from Knee to Temporomandibular Joint. Curr Osteoporos Rep 19, 166–174 (2021). https://doi.org/10.1007/s11914-021-00661-3

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