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Associations Between Sleep Disorders and Hypertensive Disorders of Pregnancy and Materno-fetal Consequences

  • Sleep and Hypertension (S Justin Thomas, Section Editor)
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Abstract

Purpose of the Review

To review the data supporting the associations between sleep disorders and hypertensive disorders of pregnancy, their diagnosis, consequences, treatment, and potential mechanisms.

Recent Findings

The prevalence of sleep-disordered breathing, insomnia, and restless legs syndrome increases as pregnancy progresses secondary to physiologic changes associated with pregnancy. Sleep-disordered breathing is strongly associated with the development of gestational hypertension and preeclampsia, both of which are associated with increased risk of perinatal complications. Diagnosing sleep disorders in pregnant presents added challenges, but polysomnography remains the gold standard for diagnosing sleep-disordered breathing in this group.

Summary

Sleep disorders, and especially sleep-disordered breathing, are highly prevalent among pregnant women and associated with hypertensive disorders of pregnancy. Clinicians should be mindful of this association and endeavor to identify at-risk women for further evaluation.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Guyton and Hall. Textbook of medical physiology. 13th ed: Elsevier.

  2. Somers VK, White DP, Amin R, Abraham WT, Costa F, Culebras A, et al. Sleep apnea and cardiovascular disease: an American Heart Association/American College of Cardiology Foundation Scientific Statement from the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, Stroke Council, and Council on Cardiovascular Nursing in Collaboration with the National Heart, Lung, and Blood Institute National Center on Sleep Disorders Research (National Institutes of Health). J Am Coll Cardiol. 2008;52:686.

    Article  Google Scholar 

  3. Vgontzas AN, Liao D, Bixler EO, Chrousos GP, Vela-Bueno A. Insomnia with objective short sleep duration is associated with a high risk for hypertension. Sleep. 2009;32:491–7.

    Article  Google Scholar 

  4. Javaheri S, Barbe F, Campos-Rodriguez F, Dempsey JA, Khayat R, Javaheri S, et al. Sleep apnea: types, mechanisms, and clinical cardiovascular consequences. J Am Coll Cardiol. 2017;69:841–58. https://doi.org/10.1016/j.jacc.2016.11.069.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Calhoun DA, Harding SM. Sleep and hypertension. Chest. 2010;138(2):434–43. https://doi.org/10.1378/chest.09-2954.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Mindell JA, Cook RA, Nikolovski J. Sleep patterns and sleep disturbances across pregnancy. Sleep Med. 2015;16:483–8. https://doi.org/10.1016/j.sleep.2014.12.006.

    Article  PubMed  Google Scholar 

  7. Mustafa R, Ahmed S, Gupta A, Venuto RC. A comprehensive review of hypertension in pregnancy. J Pregnancy. 2012:105918. https://doi.org/10.1155/2012/105918.

  8. Miller RD, Eriksson LI, Fleisher LA, Wiener-Kronish JP, Cohen NH, Young WL. Miller’s anesthesia. 9th ed: Elsevier.

  9. Larry CD, Yeo CD. The circadian rhythm of blood pressure during pregnancy. Obstet Gynecol Neonatal Nurs. 2000;29:500–5.

    Article  CAS  Google Scholar 

  10. Ohkubo T, Hozawa A, Yamaguchi J, Kikuya M, et al. Prognostic significance of the nocturnal decline in blood pressure in individuals with and without high 24-h blood pressure: the Ohasama study. J Hypertens. 2002;20:2183–9.

    Article  CAS  Google Scholar 

  11. Sasaki N, Ozono R, Edahiro Y, Ishii K, Seto A, Okita T, et al. Impact of non-dipping on cardiovascular outcomes in patients with obstructive sleep apnea. Clin Exp Hypertens. 2015;37:449–53.

    Article  CAS  Google Scholar 

  12. Oney T, Meyer-Sabellek W. Variability of arterial blood pressure in normal and hypertensive pregnancy. J Hypertens Suppl. 2010;8:S77–81.

    Google Scholar 

  13. Siamopoulos KC, Papanikolaou S, Elisaf M, Theodorou J, Pappas H, Papanikolaou N. Ambulatory blood pressure monitoring in normotensive pregnant women. J Hum Hypertens. 1996;10(Suppl 3):S51–4.

    PubMed  Google Scholar 

  14. Soydinc HE, Davutoglu V, Sak ME, Ercan S, Evsen MS, Kaya H, et al. Circadian variation of blood pressure is impaired in normotensive pregnant women with gestational diabetes mellitus. Clin Exp Hypertens. 2013;35:128–33. https://doi.org/10.3109/10641963.2012.702832.

    Article  CAS  PubMed  Google Scholar 

  15. Baszak E, Baszak J, Sikorski R, Radomanski T. Nocturnal fall of blood pressure in the first half of pregnancy. Ginekol Pol. 2001;12:1582–7.

    Google Scholar 

  16. Rojo-Contreras W, Salazar-Páramo M, Parra-Carrillo JZ, Iñigo-Riesgo CA, Bonilla-Rosales I, Villa-Manzano AI, et al. Circadian rhythm of blood pressure in patients with chronic hypertension and pregnancy. Ginecol Obstet Mex. 2014;82:604–12.

    PubMed  Google Scholar 

  17. Brown MA, Davis GK, McHugh L. The prevalence and clinical significance of nocturnal hypertension in pregnancy. J Hypertens. 2001;19:1437–44.

    Article  CAS  Google Scholar 

  18. • Saremi AT, Shafiee MA, Montazeri M, Rashidi N, Montazeri M. Blunted overnight blood pressure dipping in second trimester; a strong predictor of gestational hypertension and preeclampsia. Curr Hypertens Rev. 2019;15:70–5. https://doi.org/10.2174/1573402114666180924143801This recent study reported alterations in circadian rhythm blood pressure changes by ambulatory blood pressure monitoring and related it to later development of gestational hypertension and pre-eclampsia.

    Article  PubMed  Google Scholar 

  19. • Louis JM, Koch MA, Reddy UM, Silver RM, Parker CB, Facco FL, et al. Predictors of sleep disordered breathing in pregnancy. Am J Obstet Gynecol. 2018;218:521.e1–521.e12. https://doi.org/10.1016/j.ajog.2018.01.031A substudy of the Nulliparous Pregnancy Outcomes:Monitoring Pregnancy Outcomes (nuMoM2b) Study, included 3,705 pregnant women who underwent polysomnographies and described physical predictors of obstructive sleep apnea in pregnancy.

    Article  Google Scholar 

  20. Olivarez SA, Ferres M, Antony K, Mattewal A, Maheshwari B, Sangi-Haghpeykar H, et al. Obstructive sleep apnea screening in pregnancy, perinatal outcomes, and impact of maternal obesity. Am J Perinatol. 2011;28:651–8. https://doi.org/10.1055/s-0031-1276740.

    Article  PubMed  Google Scholar 

  21. Ugur MG, Boynukalin K, Atak Z, Ustuner I, Atakan R, Baykal C. Sleep disturbances in pregnant patients and the relation to obstetric outcome. Clin Exp Obstet Gynecol. 2012;39:214–7.

    CAS  PubMed  Google Scholar 

  22. Robertson A, Johnson P, Thornton C, Whitton AM, Middleton S, Sullivan C, et al. Relationship between recorded and reported snoring during pregnancy: Objective measurement versus questionnaire responses. Pregnancy Hypertens. 2012;2:322. https://doi.org/10.1016/j.preghy.2012.04.265.

    Article  PubMed  Google Scholar 

  23. Lockhart EM, Ben Abdallah A, Tuuli MG, Leighton BL. Obstructive sleep apnea in pregnancy: assessment of current screening tools. Obstet Gynecol. 2015;126:93–102. https://doi.org/10.1097/AOG.0000000000000848.

    Article  PubMed  Google Scholar 

  24. Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S. The occurrence of sleep disordered breathing among middle-aged adults. N Engl J Med. 1993;328:1230–5. https://doi.org/10.1056/NEJM199304293281704.

    Article  CAS  PubMed  Google Scholar 

  25. Whitney CW, Gottlieb DJ, Redline S, Norman RG, Dodge RR, Shahar E, et al. Reliability of scoring respiratory disturbance indices and sleep staging. Sleep. 1998;21:749–57.

    Article  CAS  Google Scholar 

  26. Hedner J, White DP, Malhotra A, Herscovici S, Pittman SD, Zou D, et al. Sleep staging based on autonomic signals: a multi-center validation study. J Clin Sleep Med. 2011 Jun 15;7:301–6.

    Article  Google Scholar 

  27. Yalamanchali S, Farajian V, Hamilton C, Pott TR, Samuelson CG, Friedman M. Diagnosis of obstructive sleep apnea by peripheral arterial tonometry: meta-analysis. JAMA Otolaryngol Head Neck Surg. 2013;139(12):1343–50. https://doi.org/10.1001/jamaoto.2013.5338.

    Article  PubMed  Google Scholar 

  28. • Facco FL, Grobman WA, Reid KJ, Parker CB, Hunter SM, Silver RM, et al. Objectively measured short sleep duration and later sleep midpoint in pregnancy are associated with a higher risk of gestational diabetes. Am J Obstet Gynecol. 2017;217:447.e1–447.e13. https://doi.org/10.1016/j.ajog.2017.05.066A sub-study of nuMoM2b Study that followed pregnant women with Actigraphy for one week and found no association between objective measurements of insomnia and development of hypertensive disorders of pregnancy.

    Article  Google Scholar 

  29. Madrid-Valero JJ, Martínez-Selva JM, Ribeiro do Couto B, Sánchez-Romera JF, Ordoñana JR. Age and gender effects on the prevalence of poor sleep quality in the adult population. Gac Sanit. 2017 Jan;31:18–22. https://doi.org/10.1016/j.gaceta.2016.05.013 Epub 2016 Jul 26.

  30. Fernández-Alonso AM, Trabalón-Pastor M, Chedraui P, Pérez-López FR. Factors related to insomnia and sleepiness in the late third trimester of pregnancy. Arch Gynecol Obstet. 2012;286:55–61. https://doi.org/10.1007/s00404-012-2248-z.

    Article  PubMed  Google Scholar 

  31. •• Sedov ID, Cameron EE, Madigan S, Tomfohr-Madsen LM. Sleep quality during pregnancy:a meta-analysis. Sleep Med Rev. 2018;38:168–76 A meta-analysis including 24 studies of pregnant women undergoing Pitsbourgh questionnaires reporting significant reduction and impoverishment of sleep while pregnant.

    Article  Google Scholar 

  32. • Okada K, Saito I, Katada C, Tsujino T. Influence of quality of sleep in the first trimester on blood pressure in the third trimester in primipara women. Blood Press. 2019;28:345–55. https://doi.org/10.1080/08037051.2019.1637246.

    Article  CAS  PubMed  Google Scholar 

  33. Okun ML, O'Brien LM. Concurrent insomnia and habitual snoring are associated with adverse pregnancy outcomes. Sleep Med. 2018;46:12–9. https://doi.org/10.1016/j.sleep.2018.03.004.

    Article  PubMed  Google Scholar 

  34. Hayase M, Shimada M, Seki H. Sleep quality and stress in women with pregnancy-induced hypertension and gestational diabetes mellitus. Women Birth. 2014:190–5. https://doi.org/10.1016/j.wombi.2014.04.002.

  35. • Chen SJ, Shi L, Bao YP, Sun YK, Lin X, Que JY, et al. Prevalence of restless legs syndrome during pregnancy: A systematic review and meta-analysis. Sleep Med Rev. 2018;40:43–54. https://doi.org/10.1016/j.smrv.2017.10.003A meta-analysis including 27 studies reporting frequency of restless legs syndrome around the world.

    Article  PubMed  Google Scholar 

  36. • Dunietz GL, Lisabeth LD, Shedden K, Shamim-Uzzaman QA, Bullough AS, Chames MC, et al. Restless legs syndrome and sleep-wake disturbances in pregnancy. J Clin Sleep Med. 2017;13:863–70 A study reports very high frequencies among pregnant women and its important contribution to poor sleep quality in pregnancy, however, finds no association with maternal or fetal complications.

    Article  Google Scholar 

  37. Liu G, Li L, Zhang J, Xue R, Zhao X, Zhu K, et al. Restless legs syndrome and pregnancy or delivery complications in China: a representative survey. Sleep Med. 2016;17:158–62. https://doi.org/10.1016/j.sleep.2015.02.541.

    Article  CAS  PubMed  Google Scholar 

  38. Sharma SK, Nehra A, Sinha S, Soneja M, Sunesh K, Sreenivas V, et al. Sleep disorders in pregnancy and their association with pregnancy outcomes: a prospective observational study. Sleep Breath. 2016;20:87–93. https://doi.org/10.1007/s11325-015-1188-9.

    Article  CAS  PubMed  Google Scholar 

  39. Dempsey JA, Veasey SC, Morgan BJ, O’Donnell CP. Pathophysiology of sleep apnea. Physiol Rev. 2010;90:47–112.

    Article  CAS  Google Scholar 

  40. Somers VK, Dyken ME, Clary MP, Abboud FM. Sympathetic neural mechanisms in obstructive sleep apnea. J Clin Invest. 1995;96:1897–904.

    Article  CAS  Google Scholar 

  41. Champagne K, Schwartzman K, Opatrny L, Barriga P, Morin L, Mallozzi A, et al. Obstructive sleep apnoea and its association with gestational hypertension. Eur Respir J. 2009;33:559–65. https://doi.org/10.1183/09031936.00122607.

    Article  CAS  PubMed  Google Scholar 

  42. Facco FL, Parker CB, Reddy UM, et al. NuMoM2b sleep-disordered breathing study: objectives and methods. Am J Obstet Gynecol. 2015;212:542.e1–542.e127.

    Article  Google Scholar 

  43. Facco FL, Ouyang DW, Zee PC, Grobman WA. Sleep disordered breathing in a high-risk cohort prevalence and severity across pregnancy. Am J Perinatol. 2014;31:899–904.

    Article  Google Scholar 

  44. Edwards N, Blyton DM, Hennessy A, Sullivan CE. Severity of sleep-disordered breathing improves following parturition. Sleep. 2005;28:737–41.

    Article  Google Scholar 

  45. Ursavas A, Karadag M, Nalci N, Ercan I, Gozu RO. Self-reported snoring, maternal obesity and neck circumference as risk factors for pregnancy-induced hypertension and preeclampsia. Respiration. 2008;76:33–9.

    Article  Google Scholar 

  46. Izci B, Martin SE, Dundas KC, Liston WA, Calder AA, Douglas NJ. Sleep complaints:snoring and daytime sleepiness in pregnant and pre-eclamptic women. Sleep Med. 2005;6:163–9.

    Article  Google Scholar 

  47. Louis J, Auckley D, Miladinovic B, Shepherd A, Mencin P, Kumar D, et al. Perinatal outcomes associated with obstructive sleep apnea in obese pregnant women. Obstet Gynecol. 2012;120:1085–92. https://doi.org/10.1097/AOG.0b013e31826eb9d8.

    Article  PubMed  Google Scholar 

  48. Owusu JT, Anderson FJ, Coleman J, Oppong S, Seffah JD, Aikins A, et al. Association of maternal sleep practices with pre-eclampsia, low birth weight, and stillbirth among Ghanaian women. Int J Gynaecol Obstet. 2013 Jun;121:261–5. https://doi.org/10.1016/j.ijgo.2013.01.013 Epub 2013 Mar 15.

  49. Karaduman M, Sarı O, Aydoğan U, Akpak YK, Semiz A, Yılanlıoğlu NC, et al. Evaluation of obstructive sleep apnea symptoms in pregnant women with chronic disease. J Matern Fetal Neonatal Med. 2016;29:3379–85. https://doi.org/10.3109/14767058.2015.1127346.

    Article  CAS  PubMed  Google Scholar 

  50. Louis JM, Auckley D, Sokol RJ, Mercer BM. Maternal and neonatal morbidities associated with obstructive sleep apnea complicating pregnancy. Am J Obstet Gynecol. 2010;202:261.e1-5. https://doi.org/10.1016/j.ajog.2009.10.867.

    Article  PubMed  Google Scholar 

  51. Pien GW, Pack AI, Jackson N, Maislin G, Macones GA, Schwab RJ. Risk factors for sleep disordered breathing in pregnancy. Thorax. 2014;69:371–7. https://doi.org/10.1136/thoraxjnl-2012-202718.

    Article  PubMed  Google Scholar 

  52. Pérez-Chada D, Videla AJ, O'Flaherty ME, Majul C, Catalini AM, Caballer CA, et al. Snoring, witnessed sleep apnoeas and pregnancy-induced hypertension. Acta Obstet Gynecol Scand. 2007;86:788–92.

    Article  Google Scholar 

  53. Bin YS, Cistulli PA, Ford JB. Population-based study of sleep apnea in pregnancy and maternal and infant outcomes. J Clin Sleep Med. 2016;12:871–7. https://doi.org/10.5664/jcsm.5890.

    Article  PubMed  PubMed Central  Google Scholar 

  54. • Bourjeily G, Danilack VA, Bublitz MH, Lipkind H, Muri J, Caldwell D, et al. Obstructive sleep apnea in pregnancy is associated with adverse maternal outcomes:a national cohort. Sleep Med, A study based on a national registry that reports significant association between sleep apnea and maternal complications of pregnancy independently of obesity. 2017;38:50–7. https://doi.org/10.1016/j.sleep.2017.06.035.

  55. • Spence DL, Allen RC, Lutgendorf MA, Gary VR, Richard JD, Gonzalez SC. Association of obstructive sleep apnea with adverse pregnancy-related outcomes in military hospitals. Eur J Obstet Gynecol Reprod Biol. 2017;210:166–72. https://doi.org/10.1016/j.ejogrb.2016.12.013Pregnant women with sleep apnea do have more maternal and fetal complications when compared with matched non sleep apnea women.

    Article  PubMed  Google Scholar 

  56. •• Liu L, Su G, Wang S, Zhu B. The prevalence of obstructive sleep apnea and its association with pregnancy-related health outcomes: a systematic review and meta-analysis. Sleep Breath. 2019;23:399–412. https://doi.org/10.1007/s11325-018-1714-7A meta-analysis including 33 studies that reports the frequency of sleep disordered breathing around the world and the association with maternal complications including gestational hypertension and diabetes, preeclampsia, and others as well as with fetal outcomes.

    Article  PubMed  Google Scholar 

  57. • Jaimchariyatam N, Na-Rungsri K, Tungsanga S, Lertmaharit S, Lohsoonthorn V, Totienchai S. Obstructive sleep apnea as a risk factor for preeclampsia-eclampsia. Sleep Breath. 2019;23:687–93. https://doi.org/10.1007/s11325-018-1758-8Among Thai pregnant women a high risk for sleep apnea based on the Berlin Questionnaire is independently associated with high risk of pre-eclampsia and eclampsia.

    Article  PubMed  Google Scholar 

  58. O'Brien LM, Bullough AS, Owusu JT, Tremblay KA, Brincat CA, Chames MC, et al. Pregnancy-onset habitual snoring, gestational hypertension, and preeclampsia:prospective cohort study. BJOG. 2014;121:1685–93.

    Article  CAS  Google Scholar 

  59. Wilson DL, Walker SP, Fung AM, Pell G, O'Donoghue FJ, Barnes M, et al. Sleep-disordered breathing in hypertensive disorders of pregnancy: a BMI-matched study. J Sleep Res. 2018;27:e12656. https://doi.org/10.1111/jsr.12656.

    Article  PubMed  Google Scholar 

  60. Tamura H, Takasaki A, Taketani T, Tanabe M, Lee L, Tamura I, et al. Melatonin and female reproduction. J Obstet Gynaecol Res. 2014 Jan;40:1–11. https://doi.org/10.1111/jog.12177.

    Article  CAS  PubMed  Google Scholar 

  61. Grossman E, Laudon M, Zisapel N. Effect of melatonin on nocturnal blood pressure: meta analysis of randomized controlled trials. Vasc Health Risk Manag. 2011;7:577–84. https://doi.org/10.2147/VHRM.S24603.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  62. Zeman M, Dulková K, Bada V, Herichová I. Plasma melatonin concentrations in hypertensive patients with the dipping and non-dipping blood pressure profile. Life Sci. 2005;76(16):1795–803. https://doi.org/10.1016/j.lfs.2004.08.034.

    Article  CAS  PubMed  Google Scholar 

  63. Shimada M, Seki H, Samejima M, Hayase M, Shirai F. Salivary melatonin levels and sleepwake rhythms in pregnant women with hypertensive and glucose metabolic disorders: A prospective analysis. Biosci Trends. 2016;10:34–41. https://doi.org/10.5582/bst.2015.01123.

    Article  CAS  PubMed  Google Scholar 

  64. Bazalakova M. Sleep disorders in pregnancy. Semin Neurol. 2017;37:661–8.

    Article  Google Scholar 

  65. Caufriez A, Leproult R, L’Hermite-Baleriaux M, Kerkhofs M, Copinschi G. Progesterone prevents sleep disturbances and modulates GH, TSH, and melatonin secretion in postmenopausal women. J Clin Endocrinol Metab. 2011;96:E614–23.

    Article  CAS  Google Scholar 

  66. Driver HS, McLean H, Kumar DV, Farr N, Day AG, Fitzpatrick MF. The influence of the menstrual cycle on upper airway resistance and breathing during sleep. Sleep. 2005;28:449–56.

    Article  Google Scholar 

  67. Bixler EO, Vgontzas AN, Lin HM, et al. Prevalence of sleep- disordered breathing in women:effects of gender. Am J Respir Crit Care Med. 2001;163:608–13.

    Article  CAS  Google Scholar 

  68. Itasaka Y, Miyazaki S, Ishikawa K, Togawa K. The influence of sleep position and obesity on sleep apnea. Psychiatry Clin Neurosci. 2000;54:340–1.

    Article  CAS  Google Scholar 

  69. Mills GH, Chaffe AG. Sleeping positions adopted by pregnant women of more than 30 weeks gestation. Anaesthesia. 1994;49:249–50.

    Article  CAS  Google Scholar 

  70. O’Connor C, Thornley KS, Hanly PJ. Gender differences in the polysomnographic features of obstructive sleep apnea. Am J Respir Crit Care Med. 2000;161:1465–72.

    Article  Google Scholar 

  71. Elkus R, Popovich J Jr. Respiratory physiology in pregnancy. Clin Chest Med. 1992;13:555–65.

    CAS  PubMed  Google Scholar 

  72. Peppard PE, Young T, Palta M, Dempsey J, Skatrud J. Longitudinal study of moderate weight change and sleep-disordered breathing. JAMA. 2000;284:3015–21.

    Article  CAS  Google Scholar 

  73. Sahota PK, Jain SS, Dhand R. Sleep disorders in pregnancy. Curr Opin Pulm Med. 2003;9:477–83.

    Article  Google Scholar 

  74. Reid J, Taylor-Gjevre R, Gjevre J, Skomro R, Fenton M, Olatunbosun F, et al. Can gestational hypertension be modified by treating nocturnal airflow limitation? J Clin Sleep Med. 2013;9:311–7. https://doi.org/10.5664/jcsm.2574.

    Article  PubMed  PubMed Central  Google Scholar 

  75. Guilleminault C, Palombini L, Poyares D, Takaoka S, Huynh NT, El-Sayed Y. Pre-eclampsia and nasal CPAP: part 1. Early intervention with nasal CPAP in pregnant women with risk-factors for pre-eclampsia: preliminary findings. Sleep Med. 2007;9:9–14.

    Article  Google Scholar 

  76. Poyares D, Guilleminault C, Hachul H, Fujita L, Takaoka S, Tufik S, et al. Pre-eclampsia and nasal CPAP: part 2. Hypertension during pregnancy, chronic snoring, and early nasal CPAP intervention. Sleep Med. 2007;9:15–21.

    Article  Google Scholar 

  77. Blyton DM, Skilton MR, Edwards N, Hennessy A, Celermajer DS, Sullivan CE. Treatment of sleep disordered breathing reverses low fetal activity levels in preeclampsia. Sleep. 2013;36:15–21. https://doi.org/10.5665/sleep.2292.

    Article  PubMed  PubMed Central  Google Scholar 

  78. Wang K, Zhang JZ, Li J, Zhang QQ, Zhang CY, Zhong AM, et al. Maternal-infant outcome of patients with OSAHS and gestational hypertension treated by CPAP. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2017;31:293–6. https://doi.org/10.13201/j.issn.1001-1781.2017.04.011.

    Article  CAS  PubMed  Google Scholar 

  79. •• Li L, Zhao K, Hua J, Li S. Association between sleep-disordered breathing during pregnancy and maternal and fetal outcomes: an updated systematic review and meta-analysis. Front Neurol. 2018;9:91. https://doi.org/10.3389/fneur.2018.00091A meta-analysis including 35 studies and more than 35,000 pregnant women that found a significant association between sleep apnea and maternal outcomes although the association with fetal complications was unclear.

    Article  PubMed  PubMed Central  Google Scholar 

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Acknowledgments

Dr. Bello is supported by the NIH/NHLBI (K23 HL136853) and the Katz Foundation.

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Authors and Affiliations

  1. Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital, Boston, MA, USA

    Gabriela Querejeta Roca

  2. University of Illinois at Chicago College of Medicine, Chicago, IL, USA

    Jacquelyne Anyaso

  3. Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital, New York, NY, USA

    Susan Redline

  4. Division of Cardiology, Columbia University Medical Center, New York, NY, USA

    Natalie A. Bello

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  1. Gabriela Querejeta Roca
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  3. Susan Redline
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  4. Natalie A. Bello
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Correspondence to Gabriela Querejeta Roca.

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Querejeta Roca, G., Anyaso, J., Redline, S. et al. Associations Between Sleep Disorders and Hypertensive Disorders of Pregnancy and Materno-fetal Consequences. Curr Hypertens Rep 22, 53 (2020). https://doi.org/10.1007/s11906-020-01066-w

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