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A Review of Angiogenic Imbalance in HIV-Infected Hypertensive Disorders of Pregnancy

  • Preeclampsia (V Garovic, Section Editor)
  • Published:
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Abstract

Purpose of Review

This review provides a comprehensive insight into the angiogenic profile of hypertensive and normotensive pregnancies compromised by HIV infection. Furthermore, we evaluate the economic implementation of the sFlt-1/PlGF ratio and review the reports on therapeutic apheresis in limiting sFlt-1 production.

Recent Findings

In preeclampsia, an increased expression of sFlt-1 triggers angiogenic imbalance. Women of African ancestry have high levels of angiogenic factors than other racial groups. The sFlt-1/PlGF ratio shows promise in the early assessment of preeclampsia, while sFlt-1 apheresis restores angiogenic imbalance. Studies suggest antiretroviral therapy does not impact the angiogenic shift in preeclampsia development.

Summary

The angiogenic profile in pregnant women of different races influences preeclampsia development. Despite the opposing immune response in HIV infection and preeclampsia, the HIV tat protein strongly mimics vascular endothelial growth factor (VEGF); hence, it is plausible to assume that HIV infection may ameliorate the angiogenic imbalance in preeclampsia.

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Authors and Affiliations

  1. Optics and Imaging Centre, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Private Bag 7, Congella, Durban, KwaZulu-Natal, 4013, South Africa

    Sayuri Padayachee & Thajasvarie Naicker

  2. Women’s Health and HIV Research Group, Department of Obstetrics and Gynecology, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa

    Jagidesa Moodley

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  1. Sayuri Padayachee
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  2. Jagidesa Moodley
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  3. Thajasvarie Naicker
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Correspondence to Sayuri Padayachee.

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Padayachee, S., Moodley, J. & Naicker, T. A Review of Angiogenic Imbalance in HIV-Infected Hypertensive Disorders of Pregnancy. Curr Hypertens Rep 21, 69 (2019). https://doi.org/10.1007/s11906-019-0970-7

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