Abstract
Purpose of Review
Functional anorectal pain syndromes are a neglected yet often disabling clinical entity resulting in significant economic and psychological burden to the patient. The aim of this review is to update the practicing gastroenterologist/coloproctologist on the diagnosis and management of these complicated disorders.
Recent Findings
The updated Rome foundation diagnostic criteria (Rome IV) for functional anorectal pain subgroups chronic proctalgia (levator ani syndrome and unspecified functional anorectal pain) and acute proctalgia (proctalgia fugax) on the basis of symptom duration and digital rectal examination findings. Chronic proctalgia is thought to be secondary to paradoxical pelvic floor contraction in many patients and biofeedback to improve the defecation effort has proven effective for over 90% in the short term. Unfortunately, management of proctalgia fugax remains challenging and treatment outcomes modest at best.
Summary
A number of therapies to relax the pelvic floor may be employed to improve symptoms in functional anorectal pain syndromes; however, only biofeedback to improve defaecatory dynamics in patients with levator ani syndrome has proven effectiveness in a randomized setting. Further investigation of treatment approaches in proctalgia fugax is required.
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References
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Chiarioni G, Asteria C, Whitehead WE. Chronic proctalgia and chronic pelvic pain syndromes: new etiologic insights and treatment options. World J Gastroenterol. 2011;17:4447–50.
Drossman DA, Li Z, Andruzzi E, Temple R, Talley NJ, Thompson WG, et al. U.S. householder survey of functional gastrointestinal disorders: prevalence, sociodemography and health impact. Dig Dis Sci. 1993;38:1569–80.
Palsson OS, Whitehead WE, van Tilburg MAL, Chang L, Chey W, Crowell MD, et al. Development and validation of the Rome IV diagnostic questionnaire for adults. Gastroenterology. 2016;150:1481–91.
•• Rao SSC, Bharucha AE, Chiarioni G, Felt-Bersma R, Knowles C, Malcom A, et al. Anorectal disorders. Gastroenterology. 2016;150:1430–42 Experts’ consensus document on diagnosis and management of proctalgia syndromes which updates a former classification from the same Institution.
Whitehead WE, Wald A, Diamant NE, Enck P, Pemberton JH, Rao SSC. Functional disorders of the anus and rectum. In: Drossman DA, Corazziari E, Talley NJ, Thompson WG, Whitehead WE, editors. Rome II: the functional gastrointestinal disorders. 2nd ed. McLean: Degnon Associates; 2000. p. 483–542.
• Atkin GK, Suliman A, Vaizey CJ. Patient characteristics and treatment outcome in functional anorectal pain. Dis Colon Rectum. 2011;54:870–5 Large surgical case series providing real-life, meaningful data on history, diagnosis and management of proctalgia patients.
• de Paredes V, Etiennev I, Bauer P, Taouk M, Atienza P. Proctalgia fugax: demographic and clinical characteristics, what every doctor should know from a prospective study of 54 patients. Dis Colon Rectum. 2006;50:893–989 Large surgical case series providing innovative data on the clinical picture and focused diagnosis of proctalgia fugax patients.
Smith WT. Levator Syndrome. Minn Med. 1959;42:1076.
Wald A. Functional anorectal and pelvic pain. Gastroenterol Clin N Am. 2001;30:243–51.
Salvati EP. The levator syndrome and its variant. Gastroenterol Clin N Am. 1987;16:71–8.
Renzi C, Pescatori M. Psychologic aspects in proctalgia. Dis Colon Rectum. 2000;43:535–9.
•• Chiarioni G, Nardo A, Vantini I, Romito A, Whitehead WE. Biofeedback is superior to electrogalvanic stimulation and massage for treatment of levator ani syndrome. Gastroenterology. 2010;138:1321–9 Prospective, randomized, controlled trial supporting biofeedback therapy to improve defaecation effort as first choice treatment for levator ani syndrome with comorbid dyssynergic defaecation.
• Nugent E, Beal M, Sun G, Zutshi M, et al. Botulinum toxin A versus electrogalvanic stimulation for levator ani syndrome: is one a more effective therapy? Tech Coloproctol. 2019. https://doi.org/10.1007/s10151-019-02103-wLarge retrospective trial from a tertiary referral Centre suggesting that both electrogalvanic stimulations of the pelvic floor and intra-anal Botox injection may solve pain long-term in a minority of patients with levator ani syndrome unresponsive to conservative care.
Hompes R, Jones OM, Cunningham C, Lindsey I. What causes chronic idiopathic perineal pain? Color Dis. 2011;13:1035–9.
Krogh K, Chiarioni G, Whitehead W. Management of chronic constipation in adults. United European Gastroenterol J. 2017;5:465–72.
• Xue YH, Ding SQ, Ding YJ, Pan LQ. Role of three-dimensional endoanal ultrasound in assessing the anal sphincter morphology of female patients with chronic proctalgia. World J Gastroenterol. 2017;23:3900–6 Prospective imaging trial supporting dyssynergic defaecation as relevant etiology of chronic proctalgia.
Armananzas L, Arroyo A, Ruiz-Tovar J. Lo pez a, Santos J, Moya P, Gomez MA, candela F, Calpena R. chronic idiopathic anal pain. Results of a diagnostic-therapeutic protocol in a colorectal referral unit. Cir Esp. 2015;93:34–8.
Parés D, Abcarian H. Management of common benign anorectal disease: what all physicians need to know. Am J Med. 2018;131:745–51.
Chiarioni G, Kim SM, Vantini I, Whitehead WE. Validation of the balloon evacuation test: reproducibility and agreement with findings from anorectal manometry and electromyography. Clin Gastroenterol Hepatol. 2014;12:2049–54.
Gilliland R, Heymen JS, Altomare DF, Vickers D, Wexner SD. Biofeedback for intractable rectal pain: outcome and predictors of success. Dis Colon Rectum. 1997;40:190–6.
Dodi G, Bogoni F, Infantino A, Pianon P, Mortellaro LM, Lise M. Hot or cold in anal pain? A study of the changes in internal anal sphincter pressure profiles. Dis Colon Rectum. 1986;29:248–51.
Grant R, Salvati EP, Rubin RJ. Levator syndrome: analysis of 316 cases. Dis Colon Rectum. 1975;18:161–3.
Ger GC, Wexner SD, Jorge JM, Lee E, Amaranath LA, Heymen S, et al. Evaluation and treatment of chronic intractable rectal pain: a frustrating endeavor. Dis Colon Rectum. 1993;36:139–45.
Min KJ, Choi H, Tae BS, Lee MG, Lee SJ, Hong KD. Short-term benefits of balneotherapy for patients with chronic pelvic pain: a pilot study in Korea. J Obstet Gynaecol. 2019:1–6. https://doi.org/10.1080/01443615.2019.1631771.
Schneider J, Patterson M, Jimenez XF. Beyond depression: other uses for tricyclic antidepressants. Cleve Clin J Med. 2019;86:807–14.
Cohee MW, Hurff A, Gazewood JD. Benign anorectal conditions: evaluation and management. Am Fam Physician. 2020;101:24–33.
Carter D, Dickman R. The role of Botox in colorectal disorders. Curr Treat Options Gastroenterol. 2018;16:541–7.
Rao SSC, Paulson J, Mata M, Zimmerman B. Clinical trial: effects of botulinum toxin on levator ani syndrome: a double-blind, placebo-controlled study. Aliment Pharmacol Ther. 2009;29:985–91.
•• Ooijevaar RE, Felt-Bersma RJF, Han-Geurts J, van Reijn D, Vollebregt PF, Molenaar CBH. Botox treatment in patients with chronic functional anorectal pain: experiences of a tertiary referral proctology clinic. Tech Coloproctol. 2019;23:239–44 Large retrospective trial from a tertiary referral Centre suggesting potential effectiveness of BoTox intra-anal injection to manage unspecified functional anorectal pain unresponsive to conservative care.
Bibi S, Zutshi M, Gurland B, Hull T. Is Botox for anal pain an effective treatment option? Postgrad Med. 2016;128:41–5.
Sohn N, Weinstein MA, Robbins RD. The levator syndrome and its treatment with high-voltage electrogalvanic stimulation. Am J Surg. 1982;144:580–2.
Hull TL, Milsom JW, Church J, Oakley J, Lavery I, Fazio V. Electrogalvanic stimulation for levator syndrome: how effective is in the long-term? Dis Colon Rectum. 1993;36:731–3.
Chiarioni G. Biofeedback treatment of chronic constipation: myths and misconceptions. Tech Coloproctol. 2016;20:611–8.
Grimaud JC, Bouvier M, Naudy B, Guien C, Salducci J. Manometric and radiologic investigatios and biofeedback treatment of chronic idiopathic anal pain. Dis Colon Rectum. 1991;34:690–5.
Chiarioni G, Palsson OS, Asteria CR, Whitehead WE. Neuromodulation for fecal incontinence: an effective surgical intervention. World J Gastroenterol. 2013;19:7048–54.
Falletto E, Masin A, Lolli P, Villani R, GanioE RV, Infantino A, et al. Is sacral nerve stimulation an effective treatment for chronic idiopathic anal pain? Dis Colon Rectum. 2009;52:456–62.
Dudding TC, Thomas GP, Hollingshead JR, George AT, Stern J, Vaizey. Sacral nerve stimulation: an effective treatment for chronic functional anal pain? Color Dis. 2013;15:1140–4.
Thaysen EH. Proctalgia fugax. Lancet. 1935;2:243–6.
Kamm MA, Hoyle CH, Burleigh DE, Law PJ, Swash M, Martin JE, et al. Hereditary internal anal sphincter myopathy causing proctalgia fugax and constipation. A newly identified condition. Gastroenterology. 1991;100:805–10.
Jeyarajah S, Chow A, Ziprin P, Tilney H, Purkayastha S. Proctalgia Fugax, an evidence-based management pathway. Int J Color Dis. 2010;25:1037–46.
Eckardt VF, Dodt O, Kanzler G, Bernhard G. Treatment of proctalgia fugax with salbutamol inhalation. Am J Gastroenterol. 1996;91:686–9.
Grigoriou M, Ioannidis A, Kofina K, Efthimiadis C. Use of botulinum A toxin for proctalgia fugax-a case report of successful treatment. J Surg Case Rep. 2017;29:rjx236. https://doi.org/10.1093/jscr/rjx236.
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Dr. Carrington has received consultancy fees for teaching from Laborie. Dr. Popa has no conflict of interest to declare. Dr. Chiarioni is a member of the Anorectal Committee of the Rome Foundation.
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All reported studies/experiments with human or animal subjects performed by the authors have been previously published and complied with all applicable ethical standards (including the Helsinki declaration and its amendments, institutional/national research committee standards and international/national/institutional guidelines).
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Carrington, E.V., Popa, SL. & Chiarioni, G. Proctalgia Syndromes: Update in Diagnosis and Management. Curr Gastroenterol Rep 22, 35 (2020). https://doi.org/10.1007/s11894-020-00768-0
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DOI: https://doi.org/10.1007/s11894-020-00768-0