Skip to main content

Advertisement

Log in

Evaluation and Management of Cirrhotic Patients Undergoing Elective Surgery

  • Liver (S Cotler and E Kallwitz, Section Editors)
  • Published:
Current Gastroenterology Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Cirrhotic patients have an increased risk of surgical complications and higher perioperative morbidity and mortality based on the severity of their liver disease. Liver disease predisposes patients to perioperative coagulopathies, volume overload, and encephalopathy. The goal of this paper is to discuss the surgical risk of cirrhotic patients undergoing elective surgeries and to discuss perioperative optimization strategies.

Recent Findings

Literature thus far varies by surgery type and the magnitude of surgical risk. CTP and MELD classification scores allow for the assessment of surgical risk in cirrhotic patients.

Summary

Once the decision has been made to undergo elective surgery, cirrhotic patients can be optimized pre-procedure with the help of a checklist and by the involvement of a multidisciplinary team. Elective surgeries should be performed at hospital centers staffed by healthcare providers experienced in caring for cirrhotic patients. Further research is needed to develop ways to prepare this complicated patient population before elective surgery.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. O'Leary JG, Yachimski PS, Friedman LS. Surgery in the patient with liver disease. Clin Liver Dis. 2009;13(2):211–31. https://doi.org/10.1016/j.cld.2009.02.002.

    Article  PubMed  Google Scholar 

  2. Patel T. Surgery in the patient with liver disease. Mayo Clin Proc. 1999;74(6):593–9. https://doi.org/10.4065/74.6.593.

    Article  CAS  PubMed  Google Scholar 

  3. Telem DA, Schiano T, Divino CM. Complicated hernia presentation in patients with advanced cirrhosis and refractory ascites: management and outcome. Surgery. 2010;148(3):538–43. https://doi.org/10.1016/j.surg.2010.01.002.

    Article  PubMed  Google Scholar 

  4. Neeff H, Mariaskin D, Spangenberg HC, Hopt UT, Makowiec F. Perioperative mortality after non-hepatic general surgery in patients with liver cirrhosis: an analysis of 138 operations in the 2000s using Child and MELD scores. J Gastrointest Surg. 2011;15(1):1–11. https://doi.org/10.1007/s11605-010-1366-9.

    Article  PubMed  Google Scholar 

  5. Andraus W, Pinheiro RS, Lai Q, Haddad LBP, Nacif LS, D'Albuquerque LAC, et al. Abdominal wall hernia in cirrhotic patients: emergency surgery results in higher morbidity and mortality. BMC Surg. 2015;15:65. https://doi.org/10.1186/s12893-015-0052-y.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Salamone G, Licari L, Guercio G, Campanella S, Falco N, Scerrino G, et al. The abdominal wall hernia in cirrhotic patients: a historical challenge. World J Emerg Surg. 2018;13:35. https://doi.org/10.1186/s13017-018-0196-z.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Petro CC, Haskins IN, Perez AJ, Tastaldi L, Strong AT, Ilie RN, et al. Hernia repair in patients with chronic liver disease - a 15-year single-center experience. Am J Surg. 2019;217(1):59–65. https://doi.org/10.1016/j.amjsurg.2018.10.020.

    Article  PubMed  Google Scholar 

  8. •• Im GY, Lubezky N, Facciuto ME, Schiano TD. Surgery in patients with portal hypertension: a preoperative checklist and strategies for attenuating risk. Clin Liver Dis. 2014;18(2):477–505. https://doi.org/10.1016/j.cld.2014.01.006. This paper discusses ways to optimize and manage patients with liver disease undergoing elective surgeries, similar to this review.

    Article  PubMed  Google Scholar 

  9. • Tan HH, Schiano TD. Effects of liver disease on drug metabolism in humans. In: Encyclopedia of drug metabolism and interactions. Hoboken: John Wiley and Sons; 2013. p. 1–46. This chapter is a comprehensive review of drug metabolism in liver disease.

    Google Scholar 

  10. Cowan RE, Jackson BT, Grainger SL, Thompson RP. Effects of anesthetic agents and abdominal surgery on liver blood flow. Hepatology. 1991;14(6):1161–6.

    CAS  PubMed  Google Scholar 

  11. Afdhal N, McHutchison J, Brown R, Jacobson I, Manns M, Poordad F, et al. Thrombocytopenia associated with chronic liver disease. J Hepatol. 2008;48(6):1000–7. https://doi.org/10.1016/j.jhep.2008.03.009.

    Article  CAS  PubMed  Google Scholar 

  12. Greenwood SM, Leffler CT, Minkowitz S. The increased mortality rate of open liver biopsy in alcoholic hepatitis. Surg Gynecol Obstet. 1972;134(4):600–4.

    CAS  PubMed  Google Scholar 

  13. Powell-Jackson P, Greenway B, Williams R. Adverse effects of exploratory laparotomy in patients with unsuspected liver disease. Br J Surg. 1982;69(8):449–51. https://doi.org/10.1002/bjs.1800690805.

    Article  CAS  PubMed  Google Scholar 

  14. Mikkelsen WP. Therapeutic portacaval shunt. Preliminary data on controlled trial and morbid effects of acute hyaline necrosis. Arch Surg. 1974;108(3):302–5. https://doi.org/10.1001/archsurg.1974.01350270036007.

    Article  CAS  PubMed  Google Scholar 

  15. •• Adamson DT, Bozeman MC, Benns MV, Burton A, Davis EG, Jones CM. Operative considerations for the general surgeon in patients with chronic liver disease. Am Surg. 2019;85(2):234–44. This paper is a comprehensive surgical perspective on the management of liver patients undergoing elective surgeries.

  16. Child CG, Turcotte JG. Surgery and portal hypertension. Major Probl Clin Surg. 1964;1:1–85.

    CAS  PubMed  Google Scholar 

  17. Pugh RN, Murray-Lyon IM, Dawson JL, Pietroni MC, Williams R. Transection of the oesophagus for bleeding oesophageal varices. Br J Surg. 1973;60(8):646–9. https://doi.org/10.1002/bjs.1800600817.

    Article  CAS  PubMed  Google Scholar 

  18. Garrison RN, Cryer HM, Howard DA, Polk HC Jr. Clarification of risk factors for abdominal operations in patients with hepatic cirrhosis. Ann Surg. 1984;199(6):648–55. https://doi.org/10.1097/00000658-198406000-00003.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Mansour A, Watson W, Shayani V, Pickleman J. Abdominal operations in patients with cirrhosis: still a major surgical challenge. Surgery. 1997;122(4):730–5; discussion 5-6. https://doi.org/10.1016/S0039-6060(97)90080-5.

    Article  CAS  PubMed  Google Scholar 

  20. Telem DA, Schiano T, Goldstone R, Han DK, Buch KE, Chin EH, et al. Factors that predict outcome of abdominal operations in patients with advanced cirrhosis. Clin Gastroenterol Hepatol. 2010;8(5):451–7, quiz e58. https://doi.org/10.1016/j.cgh.2009.12.015.

    Article  PubMed  Google Scholar 

  21. Costa BP, Sousa FC, Serodio M, Carvalho C. Value of MELD and MELD-based indices in surgical risk evaluation of cirrhotic patients: retrospective analysis of 190 cases. World J Surg. 2009;33(8):1711–9. https://doi.org/10.1007/s00268-009-0093-4.

    Article  PubMed  Google Scholar 

  22. Gines P, Guevara M. Hyponatremia in cirrhosis: pathogenesis, clinical significance, and management. Hepatology. 2008;48(3):1002–10. https://doi.org/10.1002/hep.22418.

    Article  CAS  PubMed  Google Scholar 

  23. Farnsworth N, Fagan SP, Berger DH, Awad SS. Child-Turcotte-Pugh versus MELD score as a predictor of outcome after elective and emergent surgery in cirrhotic patients. Am J Surg. 2004;188(5):580–3. https://doi.org/10.1016/j.amjsurg.2004.07.034.

    Article  PubMed  Google Scholar 

  24. Wu SL, Zheng YX, Tian ZW, Chen MS, Tan HZ. Scoring systems for prediction of mortality in decompensated liver cirrhosis: a meta-analysis of test accuracy. World J Clin Cases. 2018;6(15):995–1006. https://doi.org/10.12998/wjcc.v6.i15.995.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Goyal SK, Dixit VK, Jain AK, Mohapatra PK, Ghosh JK. Assessment of the model for end-stage liver disease (MELD) score in predicting prognosis of patients with alcoholic hepatitis. J Clin Exp Hepatol. 2014;4(1):19–24. https://doi.org/10.1016/j.jceh.2014.02.006.

    Article  PubMed  PubMed Central  Google Scholar 

  26. • Piotrowski D, Saczewska-Piotrowska A, Jaroszewicz J, Boron-Kaczmarska A. Predictive power of model for end-stage liver disease and Child-Turcotte-Pugh score for mortality in cirrhotic patients. Clin Exp Hepatol. 2018;4(4):240–6. https://doi.org/10.5114/ceh.2018.80125. This paper is a thorough review of the predictive ability of the MELD and CTP scoring systems.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Teh SH, Nagorney DM, Stevens SR, Offord KP, Therneau TM, Plevak DJ, et al. Risk factors for mortality after surgery in patients with cirrhosis. Gastroenterology. 2007;132(4):1261–9. https://doi.org/10.1053/j.gastro.2007.01.040.

    Article  PubMed  Google Scholar 

  28. Haynes SR, Lawler PG. An assessment of the consistency of ASA physical status classification allocation. Anaesthesia. 1995;50(3):195–9. https://doi.org/10.1111/j.1365-2044.1995.tb04554.x.

    Article  CAS  PubMed  Google Scholar 

  29. • Post-operative mortality risk in patients with cirrhosis. 2019. https://www.mayoclinic.org/medical-professionals/transplant-medicine/calculators/post-operative-mortality-risk-in-patients-with-cirrhosis/itt-20434721. 2019. This is a helpful tool to assess mortality risk in cirrhotic patients undergoing surgery. https://doi.org/10.4062/biomolther.2019.051

  30. Sahara K, Paredes AZ, Tsilimigras DI, Hyer JM, Merath K, Wu L, et al. Impact of liver cirrhosis on perioperative outcomes among elderly patients undergoing hepatectomy: the effect of minimally invasive surgery. J Gastrointest Surg. 2019. https://doi.org/10.1007/s11605-019-04117-z.

  31. Bhangui P, Laurent A, Amathieu R, Azoulay D. Assessment of risk for non-hepatic surgery in cirrhotic patients. J Hepatol. 2012;57(4):874–84. https://doi.org/10.1016/j.jhep.2012.03.037.

    Article  PubMed  Google Scholar 

  32. Puggioni A, Wong LL. A metaanalysis of laparoscopic cholecystectomy in patients with cirrhosis. J Am Coll Surg. 2003;197(6):921–6. https://doi.org/10.1016/j.jamcollsurg.2003.08.011.

    Article  PubMed  Google Scholar 

  33. Neri V, Ambrosi A, Di Lauro G, Fersini A, Valentino TP. Difficult cholecystectomies: validity of the laparoscopic approach. JSLS. 2003;7(4):329–33.

    PubMed  PubMed Central  Google Scholar 

  34. Curet MJ, Contreras M, Weber DM, Albrecht R. Laparoscopic cholecystectomy. Surg Endosc. 2002;16(3):453–7. https://doi.org/10.1007/s00464-001-8129-3.

    Article  CAS  PubMed  Google Scholar 

  35. Fernando R. Laparoscopic cholecystectomy. World J Surg. 2002;26(11):1401; author reply -2–1401; author reply 1402. https://doi.org/10.1007/s00268-002-1244-z.

    Article  PubMed  Google Scholar 

  36. Johnston SM, Kidney S, Sweeney KJ, Zaki A, Tanner WA, Keane FV. Changing trends in the management of gallstone disease. Surg Endosc. 2003;17(5):781–6. https://doi.org/10.1007/s00464-002-9122-1.

    Article  CAS  PubMed  Google Scholar 

  37. Diamond T, Parks RW. Perioperative management of obstructive jaundice. Br J Surg. 1997;84(2):147–9. https://doi.org/10.1002/bjs.1800840203.

    Article  CAS  PubMed  Google Scholar 

  38. Liu F, Li Y, Wei Y, Li B. Preoperative biliary drainage before resection for hilar cholangiocarcinoma: whether or not? A systematic review. Dig Dis Sci. 2011;56(3):663–72. https://doi.org/10.1007/s10620-010-1338-7.

    Article  PubMed  Google Scholar 

  39. Adler DG, Haseeb A, Francis G, Kistler CA, Kaplan J, Ghumman SS, et al. Efficacy and safety of therapeutic ERCP in patients with cirrhosis: a large multicenter study. Gastrointest Endosc. 2016;83(2):353–9. https://doi.org/10.1016/j.gie.2015.08.022.

    Article  PubMed  Google Scholar 

  40. Li DM, Zhao J, Zhao Q, Qin H, Wang B, Li RX, et al. Safety and efficacy of endoscopic retrograde cholangiopancreatography for common bile duct stones in liver cirrhotic patients. J Huazhong Univ Sci Technolog Med Sci. 2014;34(4):612–5. https://doi.org/10.1007/s11596-014-1325-x.

    Article  CAS  PubMed  Google Scholar 

  41. Navaneethan U, Njei B, Zhu X, Kommaraju K, Parsi MA, Varadarajulu S. Safety of ERCP in patients with liver cirrhosis: a national database study. Endosc Int Open. 2017;5(4):E303–E14. https://doi.org/10.1055/s-0043-102492.

    Article  PubMed  PubMed Central  Google Scholar 

  42. Eker HH, van Ramshorst GH, de Goede B, Tilanus HW, Metselaar HJ, de Man RA, et al. A prospective study on elective umbilical hernia repair in patients with liver cirrhosis and ascites. Surgery. 2011;150(3):542–6. https://doi.org/10.1016/j.surg.2011.02.026.

    Article  PubMed  Google Scholar 

  43. Carbonell AM, Wolfe LG, DeMaria EJ. Poor outcomes in cirrhosis-associated hernia repair: a nationwide cohort study of 32,033 patients. Hernia. 2005;9(4):353–7. https://doi.org/10.1007/s10029-005-0022-x.

    Article  PubMed  Google Scholar 

  44. • Schlosser KA, Kao AM, Zhang Y, Prasad T, Kasten KR, Davis BR, et al. MELD-Na score associated with postoperative complications in hernia repair in non-cirrhotic patients. Hernia. 2019;23(1):51–9. https://doi.org/10.1007/s10029-018-1849-2. This paper reviews the use of MELD-Na as a predictor of postoperative complications in hernia repair.

    Article  PubMed  Google Scholar 

  45. Cho SW, Bhayani N, Newell P, Cassera MA, Hammill CW, Wolf RF, et al. Umbilical hernia repair in patients with signs of portal hypertension: surgical outcome and predictors of mortality. Arch Surg. 2012;147(9):864–9. https://doi.org/10.1001/archsurg.2012.1663.

    Article  CAS  PubMed  Google Scholar 

  46. Azoulay D, Buabse F, Damiano I, Smail A, Ichai P, Dannaoui M, et al. Neoadjuvant transjugular intrahepatic portosystemic shunt: a solution for extrahepatic abdominal operation in cirrhotic patients with severe portal hypertension. J Am Coll Surg. 2001;193(1):46–51.

    Article  CAS  PubMed  Google Scholar 

  47. Rossle M, Ochs A, Gulberg V, Siegerstetter V, Holl J, Deibert P, et al. A comparison of paracentesis and transjugular intrahepatic portosystemic shunting in patients with ascites. N Engl J Med. 2000;342(23):1701–7. https://doi.org/10.1056/NEJM200006083422303.

    Article  CAS  PubMed  Google Scholar 

  48. Sanyal AJ, Genning C, Reddy KR, Wong F, Kowdley KV, Benner K, et al. The North American study for the treatment of refractory ascites. Gastroenterology. 2003;124(3):634–41. https://doi.org/10.1053/gast.2003.50088.

    Article  PubMed  Google Scholar 

  49. Kim JJ, Dasika NL, Yu E, Fontana RJ. Cirrhotic patients with a transjugular intrahepatic portosystemic shunt undergoing major extrahepatic surgery. J Clin Gastroenterol. 2009;43(6):574–9. https://doi.org/10.1097/MCG.0b013e31818738ef.

    Article  PubMed  Google Scholar 

  50. • Tabchouri N, Barbier L, Menahem B, Perarnau JM, Muscari F, Fares N, et al. Original study: transjugular intrahepatic portosystemic shunt as a bridge to abdominal surgery in cirrhotic patients. J Gastrointest Surg. 2019. https://doi.org/10.1007/s11605-018-4053-x. This recent paper discusses the controversial use of TIPS prior to abdominal surgeries in cirrhotic patients.

  51. Parvinian A, Bui JT, Knuttinen MG, Minocha J, Gaba RC. Transjugular intrahepatic portosystemic shunt for the treatment of medically refractory ascites. Diagn Interv Radiol. 2014;20(1):58–64. https://doi.org/10.5152/dir.2013.13131.

    Article  PubMed  Google Scholar 

  52. •• Northup PG, Friedman LS, Kamath PS. AGA clinical practice update on surgical risk assessment and perioperative management in cirrhosis: expert review. Clin Gastroenterol Hepatol. 2019;17(4):595–606. https://doi.org/10.1016/j.cgh.2018.09.043. These guidelines provide an up-to-date overview of the current standard of practice in management of cirrhotic patients.

    Article  PubMed  Google Scholar 

  53. Oh HK, Kim H, Ryoo S, Choe EK, Park KJ. Inguinal hernia repair in patients with cirrhosis is not associated with increased risk of complications and recurrence. World J Surg. 2011;35(6):1229–33; discussion 34. https://doi.org/10.1007/s00268-011-1007-9.

    Article  PubMed  Google Scholar 

  54. Serfaty L, Aumaitre H, Chazouilleres O, Bonnand AM, Rosmorduc O, Poupon RE, et al. Determinants of outcome of compensated hepatitis C virus-related cirrhosis. Hepatology. 1998;27(5):1435–40. https://doi.org/10.1002/hep.510270535.

    Article  CAS  PubMed  Google Scholar 

  55. Fattovich G, Giustina G, Degos F, Tremolada F, Diodati G, Almasio P, et al. Morbidity and mortality in compensated cirrhosis type C: a retrospective follow-up study of 384 patients. Gastroenterology. 1997;112(2):463–72. https://doi.org/10.1053/gast.1997.v112.pm9024300.

    Article  CAS  PubMed  Google Scholar 

  56. • El-Serag HB. Hepatocellular carcinoma: recent trends in the United States. Gastroenterology. 2004;127(5 Suppl 1):S27–34. This paper reviews the incidence and epidemiology of hepatocellular carcinoma in the United States.

    Article  PubMed  Google Scholar 

  57. Cucchetti A, Ercolani G, Vivarelli M, Cescon M, Ravaioli M, La Barba G, et al. Impact of model for end-stage liver disease (MELD) score on prognosis after hepatectomy for hepatocellular carcinoma on cirrhosis. Liver Transpl. 2006;12(6):966–71. https://doi.org/10.1002/lt.20761.

    Article  PubMed  Google Scholar 

  58. Procopet B, Berzigotti A. Diagnosis of cirrhosis and portal hypertension: imaging, non-invasive markers of fibrosis and liver biopsy. Gastroenterol Rep (Oxf). 2017;5(2):79–89. https://doi.org/10.1093/gastro/gox012.

    Article  Google Scholar 

  59. Meyer J, Balaphas A, Combescure C, Morel P, Gonelle-Gispert C, Buhler L. Systematic review and meta-analysis of thrombocytopenia as a predictor of post-hepatectomy liver failure. HPB (Oxford). 2019. https://doi.org/10.1016/j.hpb.2019.01.016.

  60. Buell JF, Cherqui D, Geller DA, O'Rourke N, Iannitti D, Dagher I, et al. The international position on laparoscopic liver surgery: the Louisville statement, 2008. Ann Surg. 2009;250(5):825–30. https://doi.org/10.1097/SLA.0b013e3181b3b2d8.

    Article  PubMed  Google Scholar 

  61. Kim T, Kim BW, Wang HJ, Lee HY, Won JH, Kim J, et al. Quantitative assessment of the portal pressure for the liver surgery using serological tests. Ann Surg. 2016;264(2):330–8. https://doi.org/10.1097/SLA.0000000000001460.

    Article  PubMed  Google Scholar 

  62. Truty MJ, Vauthey JN. Uses and limitations of portal vein embolization for improving perioperative outcomes in hepatocellular carcinoma. Semin Oncol. 2010;37(2):102–9. https://doi.org/10.1053/j.seminoncol.2010.03.013.

    Article  PubMed  PubMed Central  Google Scholar 

  63. Aldrighetti L, Guzzetti E, Pulitano C, Cipriani F, Catena M, Paganelli M, et al. Case-matched analysis of totally laparoscopic versus open liver resection for HCC: short and middle term results. J Surg Oncol. 2010;102(1):82–6. https://doi.org/10.1002/jso.21541.

    Article  PubMed  Google Scholar 

  64. Memeo R, de'Angelis N, Compagnon P, Salloum C, Cherqui D, Laurent A, et al. Laparoscopic vs. open liver resection for hepatocellular carcinoma of cirrhotic liver: a case-control study. World J Surg. 2014;38(11):2919–26. https://doi.org/10.1007/s00268-014-2659-z.

    Article  PubMed  Google Scholar 

  65. Martin RC, Scoggins CR, McMasters KM. Laparoscopic hepatic lobectomy: advantages of a minimally invasive approach. J Am Coll Surg. 2010;210(5):627–34, 34-6. https://doi.org/10.1016/j.jamcollsurg.2009.12.022.

    Article  PubMed  Google Scholar 

  66. Vega EA, Kutlu OC, Joechle K, De La Cruz N, Ko D, Conrad C. Preoperative prognosticators of safe laparoscopic hepatocellular carcinoma resection in advanced cirrhosis: a propensity score matching population-based analysis of 1799 Western patients. J Gastrointest Surg. 2019;23:1157–65. https://doi.org/10.1007/s11605-019-04139-7.

    Article  PubMed  Google Scholar 

  67. Nguyen GC, Correia AJ, Thuluvath PJ. The impact of cirrhosis and portal hypertension on mortality following colorectal surgery: a nationwide, population-based study. Dis Colon Rectum. 2009;52(8):1367–74. https://doi.org/10.1007/DCR.0b013e3181a80dca.

    Article  PubMed  Google Scholar 

  68. Meunier K, Mucci S, Quentin V, Azoulay R, Arnaud JP, Hamy A. Colorectal surgery in cirrhotic patients: assessment of operative morbidity and mortality. Dis Colon Rectum. 2008;51(8):1225–31. https://doi.org/10.1007/s10350-008-9336-y.

    Article  CAS  PubMed  Google Scholar 

  69. Paolino J, Steinhagen RM. Colorectal surgery in cirrhotic patients. ScientificWorldJournal. 2014;2014:239293:1–5. https://doi.org/10.1155/2014/239293.

    Article  Google Scholar 

  70. Lian L, Menon KV, Shen B, Remzi F, Kiran RP. Inflammatory bowel disease complicated by primary sclerosing cholangitis and cirrhosis: is restorative proctocolectomy safe? Dis Colon Rectum. 2012;55(1):79–84. https://doi.org/10.1097/DCR.0b013e3182315745.

    Article  PubMed  Google Scholar 

  71. Coakley KM, Sarasani S, Prasad T, Steele SR, Paquette I, Heniford BT, et al. MELD-Na score as a predictor of anastomotic leak in elective colorectal surgery. J Surg Res. 2018;232:43–8. https://doi.org/10.1016/j.jss.2018.04.012.

    Article  PubMed  Google Scholar 

  72. Brolin RE, Bradley LJ, Taliwal RV. Unsuspected cirrhosis discovered during elective obesity operations. Arch Surg. 1998;133(1):84–8. https://doi.org/10.1001/archsurg.133.1.84.

    Article  CAS  PubMed  Google Scholar 

  73. Nair S, Verma S, Thuluvath PJ. Obesity and its effect on survival in patients undergoing orthotopic liver transplantation in the United States. Hepatology. 2002;35(1):105–9. https://doi.org/10.1053/jhep.2002.30318.

    Article  PubMed  Google Scholar 

  74. Wu R, Ortiz J, Dallal R. Is bariatric surgery safe in cirrhotics? Hepat Mon. 2013;13(2):e8536. https://doi.org/10.5812/hepatmon.8536.

    Article  PubMed  PubMed Central  Google Scholar 

  75. Bonner K, Heimbach JK. Obesity management in the liver transplant recipient: the role of bariatric surgery. Curr Opin Organ Transplant. 2018;23(2):244–9. https://doi.org/10.1097/MOT.0000000000000513.

    Article  PubMed  Google Scholar 

  76. de Goede B, Klitsie PJ, Lange JF, Metselaar HJ, Kazemier G. Morbidity and mortality related to non-hepatic surgery in patients with liver cirrhosis: a systematic review. Best Pract Res Clin Gastroenterol. 2012;26(1):47–59. https://doi.org/10.1016/j.bpg.2012.01.010.

    Article  PubMed  Google Scholar 

  77. Poulsen TL, Thulstrup AM, Sorensen HT, Vilstrup H. Appendicectomy and perioperative mortality in patients with liver cirrhosis. Br J Surg. 2000;87(12):1664–5. https://doi.org/10.1046/j.1365-2168.2000.01599.x.

    Article  CAS  PubMed  Google Scholar 

  78. Tsugawa K, Koyanagi N, Hashizume M, Tomikawa M, Ayukawa K, Akahoshi K, et al. A comparison of an open and laparoscopic appendectomy for patients with liver cirrhosis. Surg Laparosc Endosc Percutan Tech. 2001;11(3):189–94. https://doi.org/10.1097/00129689-200106000-00008.

    Article  CAS  PubMed  Google Scholar 

  79. Warnick P, Mai I, Klein F, Andreou A, Bahra M, Neuhaus P, et al. Safety of pancreatic surgery in patients with simultaneous liver cirrhosis: a single center experience. Pancreatology. 2011;11(1):24–9. https://doi.org/10.1159/000323961.

    Article  PubMed  Google Scholar 

  80. Nielsen SS, Thulstrup AM, Lund L, Vilstrup H, Sorensen HT. Postoperative mortality in patients with liver cirrhosis undergoing transurethral resection of the prostate: a Danish nationwide cohort study. BJU Int. 2001;87(3):183–6. https://doi.org/10.1046/j.1464-410x.2001.02048.x.

    Article  CAS  PubMed  Google Scholar 

  81. Haynes AB, Weiser TG, Berry WR, Lipsitz SR, Breizat AH, Dellinger EP, et al. A surgical safety checklist to reduce morbidity and mortality in a global population. N Engl J Med. 2009;360(5):491–9. https://doi.org/10.1056/NEJMsa0810119.

    Article  CAS  PubMed  Google Scholar 

  82. Morrow R. Perioperative quality and improvement. Anesthesiol Clin. 2012;30(3):555–63. https://doi.org/10.1016/j.anclin.2012.07.011.

    Article  PubMed  Google Scholar 

  83. Bohmer AB, Wappler F, Tinschmann T, Kindermann P, Rixen D, Bellendir M, et al. The implementation of a perioperative checklist increases patients’ perioperative safety and staff satisfaction. Acta Anaesthesiol Scand. 2012;56(3):332–8. https://doi.org/10.1111/j.1399-6576.2011.02590.x.

    Article  CAS  PubMed  Google Scholar 

  84. Ojeda A, Moreno LA. Pain management in patients with liver cirrhosis. Gastroenterol Hepatol. 2014;37(1):35–45. https://doi.org/10.1016/j.gastrohep.2013.05.007.

    Article  PubMed  Google Scholar 

  85. Dwyer JP, Jayasekera C, Nicoll A. Analgesia for the cirrhotic patient: a literature review and recommendations. J Gastroenterol Hepatol. 2014;29(7):1356–60. https://doi.org/10.1111/jgh.12560.

    Article  CAS  PubMed  Google Scholar 

  86. Hong YM, Yoon KT, Heo J, Woo HY, Lim W, An DS, et al. The prescription pattern of acetaminophen and non-steroidal anti-inflammatory drugs in patients with liver cirrhosis. J Korean Med Sci. 2016;31(10):1604–10. https://doi.org/10.3346/jkms.2016.31.10.1604.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  87. Crosti PF, Giovannelli CA, Bardi U, Vigo PL. Hepatic blood-flow in cirrhosis. Lancet. 1971;2(7719):322.

    Article  CAS  PubMed  Google Scholar 

  88. Meierhenrich R, Wagner F, Schutz W, Rockemann M, Steffen P, Senftleben U, et al. The effects of thoracic epidural anesthesia on hepatic blood flow in patients under general anesthesia. Anesth Analg. 2009;108(4):1331–7. https://doi.org/10.1213/ane.0b013e3181966e6f.

    Article  CAS  PubMed  Google Scholar 

  89. Bunchorntavakul C, Supanun R, Atsawarungruangkit A. Nutritional status and its impact on clinical outcomes for patients admitted to hospital with cirrhosis. J Med Assoc Thail. 2016;99(Suppl 2):S47–55.

    Google Scholar 

  90. Maharshi S, Sharma BC, Srivastava S. Malnutrition in cirrhosis increases morbidity and mortality. J Gastroenterol Hepatol. 2015;30(10):1507–13. https://doi.org/10.1111/jgh.12999.

    Article  CAS  PubMed  Google Scholar 

  91. Alberino F, Gatta A, Amodio P, Merkel C, Di Pascoli L, Boffo G, et al. Nutrition and survival in patients with liver cirrhosis. Nutrition. 2001;17(6):445–50. https://doi.org/10.1016/S0899-9007(01)00521-4.

    Article  CAS  PubMed  Google Scholar 

  92. • Plauth M, Bernal W, Dasarathy S, Merli M, Plank LD, Schutz T, et al. ESPEN guideline on clinical nutrition in liver disease. Clin Nutr. 2019;38:485–521. https://doi.org/10.1016/j.clnu.2018.12.022. This paper includes the most recent ESPEN guides of the nutritional management of patients with liver disease.

    Article  PubMed  Google Scholar 

  93. Tonnesen H, Rosenberg J, Nielsen HJ, Rasmussen V, Hauge C, Pedersen IK, et al. Effect of preoperative abstinence on poor postoperative outcome in alcohol misusers: randomised controlled trial. BMJ. 1999;318(7194):1311–6. https://doi.org/10.1136/bmj.318.7194.1311.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  94. Tonnesen H. Alcohol abuse and postoperative morbidity. Dan Med Bull. 2003;50(2):139–60.

    PubMed  Google Scholar 

  95. Vinet E, Perreault P, Bouchard L, Bernard D, Wassef R, Richard C, et al. Transjugular intrahepatic portosystemic shunt before abdominal surgery in cirrhotic patients: a retrospective, comparative study. Can J Gastroenterol. 2006;20(6):401–4. https://doi.org/10.1155/2006/245082.

    Article  PubMed  PubMed Central  Google Scholar 

  96. Saad WE, Saad NE, Davies MG, Bozorgdadeh A, Orloff MS, Patel NC, et al. Elective transjugular intrahepatic portosystemic shunt creation for portal decompression in the immediate pretransplantation period in adult living related liver transplant recipient candidates: preliminary results. J Vasc Interv Radiol. 2006;17(6):995–1002. https://doi.org/10.1097/01.RVI.0000223683.87894.a4.

    Article  PubMed  Google Scholar 

  97. Schenk P, Fuhrmann V, Madl C, Funk G, Lehr S, Kandel O, et al. Hepatopulmonary syndrome: prevalence and predictive value of various cut offs for arterial oxygenation and their clinical consequences. Gut. 2002;51(6):853–9. https://doi.org/10.1136/gut.51.6.853.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  98. Saner FH, Kirchner C. Monitoring and treatment of coagulation disorders in end-stage liver disease. Visc Med. 2016;32(4):241–8. https://doi.org/10.1159/000446304.

    Article  PubMed  PubMed Central  Google Scholar 

  99. Rai R, Nagral S, Nagral A. Surgery in a patient with liver disease. J Clin Exp Hepatol. 2012;2(3):238–46. https://doi.org/10.1016/j.jceh.2012.05.003.

    Article  PubMed  PubMed Central  Google Scholar 

  100. Villanueva C, Colomo A, Bosch A, Concepcion M, Hernandez-Gea V, Aracil C, et al. Transfusion strategies for acute upper gastrointestinal bleeding. N Engl J Med. 2013;368(1):11–21. https://doi.org/10.1056/NEJMoa1211801.

    Article  CAS  PubMed  Google Scholar 

  101. Salooja N, Perry DJ. Thrombelastography. Blood Coagul Fibrinolysis. 2001;12(5):327–37. https://doi.org/10.1097/00001721-200107000-00001.

    Article  CAS  PubMed  Google Scholar 

  102. • De Pietri L, Bianchini M, Montalti R, De Maria N, Di Maira T, Begliomini B, et al. Thrombelastography-guided blood product use before invasive procedures in cirrhosis with severe coagulopathy: a randomized, controlled trial. Hepatology. 2016;63(2):566–73. https://doi.org/10.1002/hep.28148. This paper evaluates the use of TEM to guide blood product use in cirrhotics , minimizing the unnecessary use of products and thus decreasing the risk of complications.

    Article  PubMed  Google Scholar 

  103. • Michelson AD, Smolensky Koganov E, Forde EE, Carmichael SL, Frelinger AL 3rd. Avatrombopag increases platelet count but not platelet activation in patients with thrombocytopenia resulting from liver disease. J Thromb Haemost. 2018;16(12):2515–9. https://doi.org/10.1111/jth.14295. This paper presents the newest FDA-approved treatment for thrombocytopenia in liver disease that could revolutionize the management of this patient population.

    Article  CAS  PubMed  Google Scholar 

  104. Tsiompanidis E, Siakavellas SI, Tentolouris A, Eleftheriadou I, Chorepsima S, Manolakis A, et al. Liver cirrhosis-effect on QT interval and cardiac autonomic nervous system activity. World J Gastrointest Pathophysiol. 2018;9(1):28–36. https://doi.org/10.4291/wjgp.v9.i1.28.

    Article  PubMed  PubMed Central  Google Scholar 

  105. Singal AK, Salameh H, Kamath PS. Prevalence and in-hospital mortality trends of infections among patients with cirrhosis: a nationwide study of hospitalised patients in the United States. Aliment Pharmacol Ther. 2014;40(1):105–12. https://doi.org/10.1111/apt.12797.

    Article  CAS  PubMed  Google Scholar 

  106. Hagstrom H, Nasr P, Ekstedt M, Hammar U, Stal P, Askling J, et al. Cardiovascular risk factors in non-alcoholic fatty liver disease. Liver Int. 2019;39(1):197–204. https://doi.org/10.1111/liv.13973.

    Article  PubMed  Google Scholar 

  107. Fan ST, Lo CM, Lai EC, Chu KM, Liu CL, Wong J. Perioperative nutritional support in patients undergoing hepatectomy for hepatocellular carcinoma. N Engl J Med. 1994;331(23):1547–52. https://doi.org/10.1056/NEJM199412083312303.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Thomas D. Schiano.

Ethics declarations

Conflict of Interest

The authors declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This article is part of the Topical Collection on Liver

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Diaz, K.E., Schiano, T.D. Evaluation and Management of Cirrhotic Patients Undergoing Elective Surgery. Curr Gastroenterol Rep 21, 32 (2019). https://doi.org/10.1007/s11894-019-0700-y

Download citation

  • Published:

  • DOI: https://doi.org/10.1007/s11894-019-0700-y

Keywords

Navigation