Skip to main content
Log in

Do measures of vascular compliance correlate with endothelial function?

  • Published:
Current Diabetes Reports Aims and scope Submit manuscript

Abstract

Accumulating evidence demonstrates that measures of vascular compliance correlate with endothelial function in animal models and patients with cardiovascular, metabolic, and kidney diseases. Nitric oxide modulates not only endothelial function, but also vascular compliance. Disruption of normal endothelial function may, at least partially, be responsible for reduced vascular compliance. Thus, nitric oxide may play a pivotal role as a mechanistic link between impaired vascular compliance and endothelial dysfunction.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References and Recommended Reading

  1. Nigam A, Mitchell GF, Lambert J, et al.: Relation between conduit vessel stiffness (assessed by tonometry) and endothelial function (assessed by flow-mediated dilatation) in patients with and without coronary heart disease. Am J Cardiol 2003, 92:395–399.

    Article  PubMed  Google Scholar 

  2. Dogra G, Irish A, Chan D, et al.: Insulin resistance, inflammation, and blood pressure determine vascular dysfunction in CKD. Am J Kidney Dis 2006, 48:926–934.

    Article  PubMed  CAS  Google Scholar 

  3. Nestel P: Relationship between arterial stiffness and glucose metabolism in women with metabolic syndrome. Clin Exp Pharmacol Physiol 2006, 33:883–886.

    Article  PubMed  CAS  Google Scholar 

  4. Schram MT, Henry RM, van Dijk RA, et al.: Increased central artery stiffness in impaired glucose metabolism and type 2 diabetes: the Hoorn Study. Hypertension 2004, 43:176–181.

    Article  PubMed  CAS  Google Scholar 

  5. Mitchell GF, Izzo JL Jr, Lacourciere Y, et al.: Omapatrilat reduces pulse pressure and proximal aortic stiffness in patients with systolic hypertension: results of the conduit hemodynamics of omapatrilat international research study. Circulation 2002, 105:2955–2961.

    Article  PubMed  CAS  Google Scholar 

  6. Mitchell GF, Lacourciere Y, Ouellet JP, et al.: Determinants of elevated pulse pressure in middle-aged and older subjects with uncomplicated systolic hypertension: the role of proximal aortic diameter and the aortic pressure-flow relationship. Circulation 2003, 108:1592–1598.

    Article  PubMed  Google Scholar 

  7. Glasser SP, Arnett DK, McVeigh GE, et al.: Vascular compliance and cardiovascular disease: a risk factor or a marker? Am J Hypertens 1997, 10(10 Pt 1):1175–1189.

    Article  PubMed  CAS  Google Scholar 

  8. Wilkinson IB, MacCallum H, Rooijmans DF, et al.: Increased augmentation index and systolic stress in type 1 diabetes mellitus. QJM 2000, 93:441–448.

    Article  PubMed  CAS  Google Scholar 

  9. Glasser SP, Arnett DK, McVeigh GE, et al.: The importance of arterial compliance in cardiovascular drug therapy. J Clin Pharmacol 1998, 38:202–212.

    PubMed  CAS  Google Scholar 

  10. Safar ME, Laurent P: Pulse pressure and arterial stiffness in rats: comparison with humans. Am J Physiol 2003, 285: H1363–H1369.

    CAS  Google Scholar 

  11. Chemla D, Hebert JL, Coirault C, et al.: Total arterial compliance estimated by stroke volume-to-aortic pulse pressure ratio in humans. Am J Physiol 1998, 274(2 Pt 2): H500–H505.

    PubMed  CAS  Google Scholar 

  12. Wilkinson IB, Prasad K, Hall IR, et al.: Increased central pulse pressure and augmentation index in subjects with hypercholesterolemia. J Am Coll Cardiol 2002, 39:1005–1011.

    Article  PubMed  Google Scholar 

  13. O’Rourke MF, Gallagher DE: Pulse wave analysis. J Hypertens Suppl 1996, 14:S147–S157.

    Article  PubMed  CAS  Google Scholar 

  14. Wilkinson IB, Hall IR, MacCallum H, et al.: Pulse-wave analysis: clinical evaluation of a noninvasive, widely applicable method for assessing endothelial function. Arterioscler Thromb Vasc Biol 2002, 22:147–152.

    Article  PubMed  CAS  Google Scholar 

  15. Van Doornum S, McColl G, Jenkins A, et al.: Screening for atherosclerosis in patients with rheumatoid arthritis: comparison of two in vivo tests of vascular function. Arthritis Rheum 2003, 48:72–80.

    Article  PubMed  Google Scholar 

  16. Wang YX: Measurement of pulse wave velocity. In A Handbook of Mouse Models of Cardiovascular Disease. Edited by Xu Q. Hoboken, NJ: John Wiley & Sons; 2006:245–254.

    Google Scholar 

  17. Wang YX, Fitch RM: Vascular stiffness: measurements, mechanisms and implications. Curr Vasc Pharmacol 2004, 2:379–384.

    Article  PubMed  CAS  Google Scholar 

  18. Fitch RM, Rutledge JC, Wang YX, et al.: Synergistic effect of angiotensin II and nitric oxide synthase inhibitor in increasing aortic stiffness in mice. Am J Physiol 2006, 290: H1190–H1198.

    CAS  Google Scholar 

  19. Fitch RM, Vergona R, Sullivan ME, et al.: Nitric oxide synthase inhibition increases aortic stiffness measured by pulse wave velocity in rats. Cardiovasc Res 2001, 51:351–358.

    Article  PubMed  CAS  Google Scholar 

  20. Hartley CJ, Reddy AK, Madala S, et al.: Hemodynamic changes in apolipoprotein E-knockout mice. Am J Physiol 2000, 279:H2326–H2334.

    CAS  Google Scholar 

  21. Wang YX, Fitch R, Li W, et al.: Reduction of cardiac functional reserve and elevation of aortic stiffness in hyperlipidemic Yucatan minipigs with systemic and coronary atherosclerosis. Vasc Pharmacol 2002, 39:69–76.

    Article  CAS  Google Scholar 

  22. Wang YX, Halks-Miller M, Vergona R, et al.: Increased aortic stiffness assessed by pulse wave velocity in apolipoprotein E-deficient mice. Am J Physiol 2000, 278: H428–H434.

    CAS  Google Scholar 

  23. Wilkinson IB, MacCallum H, Cockcroft JR, et al.: Inhibition of basal nitric oxide synthesis increases aortic augmentation index and pulse wave velocity in vivo. Br J Clin Pharmacol 2002, 53:189–192.

    Article  PubMed  CAS  Google Scholar 

  24. Oliver JJ, Webb DJ: Noninvasive assessment of arterial stiffness and risk of atherosclerotic events. Arterioscler Thromb Vasc Biol 2003, 23:554–566.

    Article  PubMed  CAS  Google Scholar 

  25. Tham DM, Martin-McNulty B, Wang YX, et al.: Angiotensin II injures the arterial wall causing increased aortic stiffening in apolipoprotein E-deficient mice. Am J Physiol Regul Integr Comp Physiol 2002, 283:R1442–R1449.

    PubMed  CAS  Google Scholar 

  26. Brunner H, Cockcroft JR, Deanfield J, et al.: Endothelial function and dysfunction. Part II: Association with cardiovascular risk factors and diseases. A statement by the Working Group on Endothelins and Endothelial Factors of the European Society of Hypertension. J Hypertens 2005, 23:233–246.

    Article  PubMed  CAS  Google Scholar 

  27. Hsueh WA, Lyon CJ, Quinones MJ: Insulin resistance and the endothelium. Am J Med 2004, 117:109–117.

    Article  PubMed  CAS  Google Scholar 

  28. Hsueh WA, Quinones MJ: Role of endothelial dysfunction in insulin resistance. Am J Cardiol 2003, 92(4A):10J–17J.

    Article  PubMed  CAS  Google Scholar 

  29. Deanfield J, Donald A, Ferri C, et al.: Endothelial function and dysfunction. Part I: Methodological issues for assessment in the different vascular beds: a statement by the Working Group on Endothelin and Endothelial Factors of the European Society of Hypertension. J Hypertens 2005, 23:7–17.

    Article  PubMed  CAS  Google Scholar 

  30. Wang YX, Martin-McNulty B, Huw LY, et al.: Anti-atherosclerotic effect of simvastatin depends on the presence of apolipoprotein E. Atherosclerosis 2002, 162:23–31.

    Article  PubMed  CAS  Google Scholar 

  31. Fitch R, Da Cunha V, Kauser K, et al.: Increased nitric oxide accounts for decreased basal vascular tone and responsiveness in the resistance vessels of high-cholesterolfed rabbits. Pharmacology 2001, 63:220–227.

    Article  PubMed  CAS  Google Scholar 

  32. Wang YX, Brooks DP, Edwards RM: Attenuated glomerular cGMP production and renal vasodilation in streptozotocin-induced diabetic rats. Am J Physiol 1993, 264(5 Pt 2):R952–R956.

    PubMed  CAS  Google Scholar 

  33. Woodman RJ, Chew GT, Watts GF: Mechanisms, significance and treatment of vascular dysfunction in type 2 diabetes mellitus: focus on lipid-regulating therapy. Drugs 2005, 65:31–74.

    Article  PubMed  CAS  Google Scholar 

  34. Vanhoutte PM, De Mey J: Control of vascular smooth muscle function by the endothelial cells. Gen Pharmacol 1983, 14:39–41.

    PubMed  CAS  Google Scholar 

  35. Kinlay S, Creager MA, Fukumoto M, et al.: Endothelium-derived nitric oxide regulates arterial elasticity in human arteries in vivo. Hypertension 2001, 38:1049–1053.

    PubMed  CAS  Google Scholar 

  36. Bank AJ, Kaiser DR, Rajala S, et al.: In vivo human brachial artery elastic mechanics: effects of smooth muscle relaxation. Circulation 1999, 100:41–47.

    PubMed  CAS  Google Scholar 

  37. Latson TW, Hunter WC, Katoh N, et al.: Effect of nitroglycerin on aortic impedance, diameter, and pulse-wave velocity. Circ Res 1988, 62:884–890.

    PubMed  CAS  Google Scholar 

  38. Wilkinson IB, Qasem A, McEniery CM, et al.: Nitric oxide regulates local arterial distensibility in vivo. Circulation 2002, 105:213–217.

    Article  PubMed  CAS  Google Scholar 

  39. Ito A, Egashira K, Kadokami T, et al.: Chronic inhibition of endothelium-derived nitric oxide synthesis causes coronary microvascular structural changes and hyperreactivity to serotonin in pigs. Circulation 1995, 92:2636–2644.

    PubMed  CAS  Google Scholar 

  40. Numaguchi K, Egashira K, Takemoto M, et al.: Chronic inhibition of nitric oxide synthesis causes coronary microvascular remodeling in rats. Hypertension 1995, 26(6 Pt 1):957–962.

    PubMed  CAS  Google Scholar 

  41. Takemoto M, Egashira K, Tomita H, et al.: Chronic angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade: effects on cardiovascular remodeling in rats induced by the long-term blockade of nitric oxide synthesis. Hypertension 1997, 30:1621–1627.

    PubMed  CAS  Google Scholar 

  42. Takemoto M, Egashira K, Tsutsui Y, et al.: [Vascular remodeling and nitric oxide] [article in Japanese]. Rinsho Byori 1997, Feb(suppl 104):216–223.

    Google Scholar 

  43. Takemoto M, Egashira K, Usui M, et al.: Important role of tissue angiotensin-converting enzyme activity in the pathogenesis of coronary vascular and myocardial structural changes induced by long-term blockade of nitric oxide synthesis in rats. J Clin Invest 1997, 99:278–287.

    Article  PubMed  CAS  Google Scholar 

  44. Wight TN: Arterial wall. In Extracellular Matrix. Edited by Comper WD. Amsterdam, The Netherlands: Harwood Academic; 1996:476–498.

    Google Scholar 

  45. Nakamura M, Sugawara S, Arakawa N, et al.: Reduced vascular compliance is associated with impaired endothelium-dependent dilatation in the brachial artery of patients with congestive heart failure. J Cardiac Fail 2004, 10:36–42.

    Article  CAS  Google Scholar 

  46. Neutel JM: Effect of the renin-angiotensin system on the vessel wall: using ACE inhibition to improve endothelial function. J Human Hypertension 2004, 18:599–606.

    Article  CAS  Google Scholar 

  47. Shige H, Dart A, Nestel P: Simvastatin improves arterial compliance in the lower limb but not in the aorta. Atherosclerosis 2001, 155:245–250.

    Article  PubMed  CAS  Google Scholar 

  48. Asakawa T, Kawasaki T, Yagi S, et al.: Non-invasive measurement of the mechanical property of arterial tree. J Jpn Coll Angiol 1985, 25:453–460.

    Google Scholar 

  49. Sato M, Katsuki Y, Kanehiro H, et al.: Effects of ethyl all-cis-5,8,11,14,17-icosapentaenoate on the physical properties of arterial walls in high cholesterol diet-fed rabbits. J Cardiovasc Pharmacol 1993, 22:1–9.

    Article  PubMed  CAS  Google Scholar 

  50. Anderson TJ: Arterial stiffness or endothelial dysfunction as a surrogate marker of vascular risk. Can J Cardiol 2006, 22(suppl B):72B–80B.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Yi-Xin Wang MD.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wang, YX. Do measures of vascular compliance correlate with endothelial function?. Curr Diab Rep 7, 265–268 (2007). https://doi.org/10.1007/s11892-007-0042-2

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11892-007-0042-2

Keywords

Navigation