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Efficacy of Bioactive Compounds in the Regulation of Metabolism and Pathophysiology in Cardiovascular Diseases

  • New Therapies for Cardiovascular Disease (AA Bavry and M Massoomi, Section Editors)
  • Published:
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Abstract

Purpose of Review

An imbalance in reactive oxygen species (ROS) homeostasis can wreak damage to metabolic and physiological processes which can eventually lead to an advancement in cardiovascular diseases (CVD). Mitochondrial dysfunction is considered as a key source of ROS. The purpose of the current review is to concisely discuss the role of bioactive compounds in the modulation of cardiovascular metabolism and their potential application in the management of cardiovascular diseases.

Recent Findings

Recently, it has been shown that bioactive compounds exhibit immunomodulatory function by regulating inflammatory pathways and ROS homeostasis. It has also been reported that bioactive compounds regulate mitochondria dynamics, thus modulating the autophagy and energy metabolism in the cells.

Summary

In the present article, we have discussed the roles of different bioactive compounds in the modulation of different inflammatory drivers. The functional properties of bioactive compounds in mitochondrial dynamics and its impact on cardiac disease protection have been briefly summarized. Furthermore, we have also discussed various aspects of bioactive compounds with respect to metabolism, immune modulation, circadian rhythm, and its impact on CVD’s pathophysiology.

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Data Availability

Not applicable.

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Author notes

  1. Vishakha Anand Pawar, Shivani Srivastava, Anuradha Tyagi, and Rajul Tayal contributed equally to this work.

Authors and Affiliations

  1. The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA

    Vishakha Anand Pawar

  2. Department of Pathology, School of Medicine, Yale University, New Haven, CT, 06520, USA

    Shivani Srivastava

  3. Department of cBRN, Institute of Nuclear Medicine and Allied Science, Delhi, 110054, India

    Anuradha Tyagi

  4. National Institute of Plant Genome Research, New Delhi, 110067, India

    Rajul Tayal

  5. Department of Oncology Science, OU Health Stephenson Cancer Center, Oklahoma City, OK, 73104, USA

    Surendra Kumar Shukla

  6. Department of Physiology and Cell Biology, The Ohio State University Wexner Medical Center, 473 W 12th Ave, Columbus, OH, 43210, USA

    Vinay Kumar

Authors
  1. Vishakha Anand Pawar
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  2. Shivani Srivastava
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  3. Anuradha Tyagi
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  4. Rajul Tayal
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  5. Surendra Kumar Shukla
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Contributions

Conceptualization: VK and SKS; writing—original draft preparation: VK, VAP, SS, AT, RT, VK, and SKS; writing—review and editing: VK, VAP, SS, AT, RT, VK, and SKS. All authors have read and agreed to the published version of the manuscript.

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Correspondence to Surendra Kumar Shukla or Vinay Kumar.

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Pawar, V.A., Srivastava, S., Tyagi, A. et al. Efficacy of Bioactive Compounds in the Regulation of Metabolism and Pathophysiology in Cardiovascular Diseases. Curr Cardiol Rep 25, 1041–1052 (2023). https://doi.org/10.1007/s11886-023-01917-3

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