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Electrical Storm: Current Evidence, Clinical Implications, and Future Perspectives

  • Invasive Electrophysiology and Pacing (EK Heist, Section Editor)
  • Published:
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Abstract

Purpose of Review

Electrical storm (ES) is a life-threatening medical emergency of repetitive episodes of sustained ventricular arrhythmias within a short period. Its occurrence is associated with poor short- and long-term survival, even in patients with implantable cardioverter defibrillators (ICD). Management of ES is challenging and mainly based on retrospective studies. This article reviews the existing literature on ES, presents the available data regarding its management, and proposes a new algorithm based on current evidence.

Recent Findings

Recent research could modify the management of ES supporting the role of non-selective β1 and β2 blockade and the early intervention with catheter ablation as well as strengthening the role of cardiac sympathetic denervation.

Summary

A multipronged approach should be considered for the management of ES including identification and correction of reversible causes, ICD reprogramming, drug therapy (beta-blockers—especially non-selective ones—and other anti-arrhythmic drugs) and non-pharmacologic therapies such as catheter ablation and techniques of neuroaxial modulation. Although current data suggest early aggressive management, further research is required to clarify the optimal order and combination of therapies for the prevention of future events.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Israel CW, Barold SS. Electrical storm in patients with an implanted defibrillator: a matter of definition. Ann Noninvasive Electrocardiol. 2007 Oct;12(4):375–82. https://doi.org/10.1111/j.1542-474X.2007.00187.x.

    Article  PubMed  Google Scholar 

  2. Priori SG, Blomström-Lundqvist C, Mazzanti A, Blom N, Borggrefe M, Camm J, et al. 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: The Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the European Society of Cardiology (ESC). Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC). Eur Heart J. 2015;36(41):2793–867. https://doi.org/10.1093/eurheartj/ehv316.

    Article  PubMed  Google Scholar 

  3. Guerra F, Palmisano P, Dell'Era G, Ziacchi M, Ammendola E, Pongetti G, et al. Cardiac resynchronization therapy and electrical storm: results of the OBSERVational registry on long-term outcome of ICD patients (OBSERVO-ICD). Europace. 2018;20(6):979–85. https://doi.org/10.1093/europace/eux166.

    Article  PubMed  Google Scholar 

  4. Nedios S, Darma A, Stevanello C, Richter S, Doering M, Rolf S, et al. Electrical storm in patients with implantable cardioverter-defibrillator in the era of catheter ablation: implications for better rhythm control. Heart Rhythm. 2015;12(12):2419–25. https://doi.org/10.1016/j.hrthm.2015.07.034.

    Article  PubMed  Google Scholar 

  5. Katritsis DG, Boriani G, Cosio FG, Hindricks G, Jaïs P, Josephson ME, et al. European Heart Rhythm Association (EHRA) consensus document on the management of supraventricular arrhythmias, endorsed by Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS), and SociedadLatinoamericana de EstimulaciónCardiaca y Electrofisiologia (SOLAECE). Europace. 2017;19(3):465–511. https://doi.org/10.1093/europace/euw301.

    Article  PubMed  Google Scholar 

  6. Al-Khatib SM, Stevenson WG, Ackerman MJ, Bryant WJ, Callans DJ, Curtis AB, et al. 2017 AHA/ACC/HRS Guideline for Management of Patients with Ventricular Arrhythmias and the prevention of sudden cardiac death: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. J Am CollCardiol. 2018;72(14):1677–749. https://doi.org/10.1016/j.jacc.2017.10.053.

    Article  Google Scholar 

  7. Muser D, Santangeli P, Liang JJ. Management of ventricular tachycardia storm in patients with structural heart disease. World J Cardiol. 2017;9(6):521–30. https://doi.org/10.4330/wjc.v9.i6.521.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Skogestad J, Aronsen JM. Hypokalemia-induced arrhythmias and heart failure: new insights and implications for therapy. Front Physiol. 2018;9:1500. https://doi.org/10.3389/fphys.2018.01500.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Saliba WI, Natale A. Ventricular tachycardia syndromes. Med Clin N Am. 2001;85:267–304. https://doi.org/10.1016/S0025-7125(05)70316-3.

    Article  CAS  PubMed  Google Scholar 

  10. van Rees JB, Borleffs CJ, de Bie MK, Stijnen T, van Erven L, Bax JJ, et al. Inappropriate implantable cardioverter-defibrillator shocks: incidence, predictors, and impact on mortality. J Am CollCardiol. 2011;57(5):556–62. https://doi.org/10.1016/j.jacc.2010.06.059.

    Article  Google Scholar 

  11. Hofer D, Steffel J, Hürlimann D, Haegeli L, Lüscher TF, Duru F, et al. Long-term incidence of inappropriate shocks in patients with implantable cardioverter defibrillators in clinical practice-an underestimated complication? J Interv Card Electrophysiol. 2017;50(3):219–26. https://doi.org/10.1007/s10840-017-0297-8.

    Article  PubMed  Google Scholar 

  12. Poole JE, Johnson GW, Hellkamp AS, Anderson J, Callans DJ, Raitt MH, et al. Prognostic importance of defibrillator shocks in patients with heart failure. N Engl J Med. 2008;359(10):1009–17. https://doi.org/10.1056/NEJMoa071098.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Brewster J, Sexton T, Dhaliwal G, Charnigo R, Morales G, Parrott K, et al. Acute effects of implantable cardioverter-defibrillator shocks on biomarkers of myocardial injury, apoptosis, heart failure, and systemic inflammation. Pacing ClinElectrophysiol. 2017;40(4):344–52. https://doi.org/10.1111/pace.13037.

    Article  Google Scholar 

  14. Semmler V, Biermann J, Haller B, Jilek C, Sarafoff N, Lennerz C, et al. ICD shock, not ventricular fibrillation, causes elevation of high sensitive troponin T after defibrillation threshold testing--the prospective, randomized, MulticentreTropShock-Trial. PLoS One. 2015;10(7):e0131570. https://doi.org/10.1371/journal.pone.0131570.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Gasparini M, Proclemer A, Klersy C, Kloppe A, Lunati M, Ferrer JB, et al. Effect of long-detection interval vs standard-detection interval for implantable cardioverter-defibrillators on antitachycardia pacing and shock delivery: the ADVANCE III randomized clinical trial. JAMA. 2013;309(18):1903–11. https://doi.org/10.1001/jama.2013.4598.

    Article  CAS  PubMed  Google Scholar 

  16. Wathen MS, De Groot PJ, Sweeney MO, Stark AJ, Otterness MF, Adkisson WO, et al. Prospective randomized multicenter trial of empirical antitachycardia pacing versus shocks for spontaneous rapid ventricular tachycardia in patients with implantable cardioverter defibrillators: PainFREE Rx II Trial Results. Circulation. 2004;104:796–801. https://doi.org/10.1161/01.CIR.0000145610.64014.E4.

    Article  Google Scholar 

  17. Vaseghi M, Shivkumar K. The role of the autonomic nervous system in sudden cardiac death. ProgCardiovasc Dis. 2008;50(6):404–19. https://doi.org/10.1016/j.pcad.2008.01.003.

    Article  CAS  Google Scholar 

  18. Zipes DP, Barber MJ, Takahashi N, Gilmour RF. Influence of the autonomic nervous system on the genesis of cardiac arrhythmias. Pacing ClinElectrophysiol. 1983;6:1210–20.

    Article  CAS  Google Scholar 

  19. Anderson JL, Rodier HE, Green LS. Comparative effects of beta-adrenergic blocking drugs on experimental ventricular fibrillation threshold. Am J Cardiol. 1983;51(7):1196–202. https://doi.org/10.1016/0002-9149(83)90368-5.

    Article  CAS  PubMed  Google Scholar 

  20. Brodine WN, Tung RT, Lee JK, Hockstad ES, Moss AJ, Zareba W, et al. Effects of beta-blockers on implantable cardioverter defibrillator therapy and survival in the patients with ischemic cardiomyopathy (from the Multicenter Automatic Defibrillator Implantation Trial-II). Am J Cardiol. 2005;96(5):691–5. https://doi.org/10.1016/j.amjcard.2005.04.046.

    Article  CAS  PubMed  Google Scholar 

  21. Nademanee K, Taylor R, Bailey WE, Rieders DE, Kosar EM. Treating electrical storm: sympathetic blockade versus advanced cardiac life support-guided therapy. Circulation. 2000;102(7):742–7.

    Article  CAS  Google Scholar 

  22. •• Chatzidou S, Kontogiannis C, Tsilimigras DI, Georgiopoulos G, Kosmopoulos M, Papadopoulou E, et al. Propranolol versus metoprolol for treatment of electrical storm in patients with implantable cardioverter-defibrillator. J Am CollCardiol. 2018;71(17):1897–906. https://doi.org/10.1016/j.jacc.2018.02.056 Findings from this study suggest that non-selective β1 and β2 blockade is superior to β1 blockade in the management of electrical storm.

    Article  CAS  Google Scholar 

  23. Bourque D, Daoust R, Huard V, Charneux M. Beta-blockers for the treatment of cardiac arrest from ventricular fibrillation? Resuscitation. 2007;75(3):434–44. https://doi.org/10.1016/j.resuscitation.2007.05.013.

    Article  CAS  PubMed  Google Scholar 

  24. Ferreira-González I, Dos-Subirá L, Guyatt GH. Adjunctive antiarrhythmic drug therapy in patients with implantable cardioverter defibrillators: a systematic review. Eur Heart J. 2007;28(4):469–77. https://doi.org/10.1093/eurheartj/ehl478.

    Article  CAS  PubMed  Google Scholar 

  25. Levine JH, Massumi A, Scheinman MM, Winkle RA, Platia EV, Chilson DA, et al. Intravenous amiodarone for recurrent sustained hypotensive ventricular tachyarrhythmias. Intravenous Amiodarone Multicenter Trial Group. J Am CollCardiol. 1996;27(1):67–75. https://doi.org/10.1016/0735-1097(95)00427-0.

    Article  CAS  Google Scholar 

  26. Kerin NZ, Blevins RD, Frumin H, Faitel K, Rubenfire M. Intravenous and oral loading versus oral loading alone with amiodarone for chronic refractory ventricular arrhythmias. Am J Cardiol. 1985;55(1):89–91. https://doi.org/10.1016/0002-9149(85)90305-4.

    Article  CAS  PubMed  Google Scholar 

  27. Connolly SJ, Dorian P, Roberts RS, Gent M, Bailin S, Fain ES, et al. Comparison of beta-blockers, amiodarone plus beta-blockers, or sotalol for prevention of shocks from implantable cardioverter defibrillators: the OPTIC Study: a randomized trial. JAMA. 2006;295(2):165–71. https://doi.org/10.1001/jama.295.2.165.

    Article  CAS  PubMed  Google Scholar 

  28. •• Santangeli P, Muser D, Maeda S, Filtz A, Zado ES, Frankel DS, et al. Comparative effectiveness of antiarrhythmic drugs and catheter ablation for the prevention of recurrent ventricular tachycardia in patients with implantable cardioverter-defibrillators: a systematic review and meta-analysis of randomized controlled trials. Heart Rhythm. 2016;13:1552–9. https://doi.org/10.1016/j.hrthm.2016.03.004 Findings from this systematic review and meta-analysis demonstrate the role of both antiarrhythmic drugs and catheter ablation for the reduction of ICD shocks. Notably, the lack of a mortality benefit highlights the need for further research.

    Article  PubMed  Google Scholar 

  29. Bardy GH, Lee KL, Mark DB, Poole JE, Packer DL, Boineau R, et al. Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. N Engl J Med. 2005;352(3):225–37. https://doi.org/10.1056/NEJMoa043399.

    Article  CAS  PubMed  Google Scholar 

  30. Jung W, Manz M, Pizzulli L, Pfeiffer D, Lüderitz B. Effects of chronic amiodarone therapy on defibrillation threshold. Am J Cardiol. 1992;70(11):1023–7. https://doi.org/10.1016/0002-9149(92)90354-2.

    Article  CAS  PubMed  Google Scholar 

  31. Gorgels AP, van den Dool A, Hofs A, Mulleneers R, Smeets JL, Vos MA, et al. Comparison of procainamide and lidocaine in terminating sustained monomorphic ventricular tachycardia. Am J Cardiol. 1996;78:43–6. https://doi.org/10.1016/S0002-9149(96)00224-X.

    Article  CAS  PubMed  Google Scholar 

  32. Ortiz M, Martín A, Arribas F, Coll-Vinent B, Del Arco C, Peinado R, et al. Randomized comparison of intravenous procainamide vs. intravenous amiodarone for the acute treatment of tolerated wide QRS tachycardia: the PROCAMIO study. Eur Heart J. 2017;38(17):1329–35. https://doi.org/10.1093/eurheartj/ehw230.

    Article  CAS  PubMed  Google Scholar 

  33. Pacifico A, Hohnloser SH, Williams JH, Tao B, Saksena S, Henry PD, et al. Prevention of implantable-defibrillator shocks by treatment with sotalol. N Engl J Med. 1999;340(24):1855–62. https://doi.org/10.1056/NEJM199906173402402.

    Article  CAS  PubMed  Google Scholar 

  34. Kettering K, Mewis C, Dörnberger V, Vonthein R, Bosch RF, Kühlkamp V. Efficacy of metoprolol and sotalol in the prevention of recurrences of sustained ventricular tachyarrhythmias in patients with an implantable cardioverter defibrillator. Pacing ClinElectrophysiol. 2002;25(11):1571–6. https://doi.org/10.1046/j.1460-9592.2002.01571.x.

    Article  Google Scholar 

  35. Waldo AL, Camm AJ, de Ruyter H, Friedman PL, DJ MN, Pauls JF, et al. Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction. The SWORD Investigators. Survival with Oral d-Sotalol. Lancet. 1996;348:7–12. https://doi.org/10.1016/S0140-6736(96)02149-6.

    Article  CAS  PubMed  Google Scholar 

  36. Deyell MW, Steinberg C, Doucette S, Parkash R, Nault I, Gray C, et al. Mexiletine or catheter ablation after amiodarone failure in the VANISH trial. J Cardiovasc Electrophysiol. 2018;29(4):603–8. https://doi.org/10.1111/jce.13431.

    Article  PubMed  Google Scholar 

  37. Lee SD, Newman D, Ham M, Dorian P. Electrophysiologic mechanisms of antiarrhythmic efficacy of a sotalol and class Ia drug combination: elimination of reverse use dependence. J Am Coll Cardiol. 1997;29(1):100–5. https://doi.org/10.1016/S0735-1097(96)00423-8.

    Article  CAS  PubMed  Google Scholar 

  38. Van Herendael H, Pinter A, Ahmad K, Korley V, Mangat I, Dorian P. Role of antiarrhythmic drugs in patients with implantable cardioverter defibrillators. Europace. 2010;12(5):618–25. https://doi.org/10.1093/europace/euq073.

    Article  PubMed  Google Scholar 

  39. Burjorjee JE, Milne B. Propofol for electrical storm; a case report of cardioversion and suppression of ventricular tachycardia by propofol. Can J Anaesth. 2002;49(9):973–7. https://doi.org/10.1007/BF03016886.

    Article  PubMed  Google Scholar 

  40. Anderson KP. Sudden cardiac death unresponsive to implantable defibrillator therapy: an urgent target for clinicians, industry and government. J Interv Card Electrophysiol. 2005;14:71–8.

    Article  Google Scholar 

  41. Mitchell LB, Pineda EA, Titus JL, Bartosch PM, Benditt DG. Sudden death in patients with implantable cardioverter defibrillators: the importance of post-shock electromechanical dissociation. J Am Coll Cardiol. 2002;39:1323–8. https://doi.org/10.1016/S0735-1097(02)01784-9.

    Article  PubMed  Google Scholar 

  42. Huang S, Miller J. Catheter ablation of cardiac arrhythmias. Elsevier Editions, 3rd Edition.

  43. Palaniswamy C, Kolte D, Harikrishnan P, Khera S, Aronow WS, Mujib M, et al. Catheter ablation of postinfarction ventricular tachycardia: ten-year trends in utilization, in-hospital complications, and in-hospital mortality in the United States. Heart Rhythm. 2014;11(11):2056–63. https://doi.org/10.1016/j.hrthm.2014.07.012.

    Article  PubMed  Google Scholar 

  44. Spartalis M, Spartalis E, Tzatzaki E, Tsilimigras DI, Moris D, Kontogiannis C, et al. Novel approaches for the treatment of ventricular tachycardia. World J Cardiol. 2018;10(7):52–9. https://doi.org/10.4330/wjc.v10.i7.52.

    Article  PubMed  PubMed Central  Google Scholar 

  45. Nayyar S, Ganesan AN, Brooks AG, Sullivan T, Roberts-Thomson KC, Sanders P. Venturing into ventricular arrhythmia storm: a systematic review and meta-analysis. Eur Heart J. 2013;34(8):560–71. https://doi.org/10.1093/eurheartj/ehs453.

    Article  PubMed  Google Scholar 

  46. Di Biase L, Santangeli P, Burkhardt DJ, Bai R, Mohanty P, Carbucicchio C, et al. Endoepicardial homogenization of the scar versus limited substrate ablation for the treatment of electrical storms in patients with ischemic cardiomyopathy. J Am Coll Cardiol. 2012;60:132–41. https://doi.org/10.1016/j.jacc.2012.03.044.

    Article  PubMed  Google Scholar 

  47. Sapp JL, Wells GA, Parkash R, Stevenson WG, Blier L, Sarrazin JF, et al. Ventricular tachycardia ablation versus escalation of antiarrhythmic drugs. N Engl J Med. 2016;375:111–21. https://doi.org/10.1056/NEJMoa1513614.

    Article  CAS  PubMed  Google Scholar 

  48. Reddy VY, Reynolds MR, Neuzil P, Richardson AW, Taborsky M, Jongnarangsin K, et al. Prophylactic catheter ablation for the prevention of defibrillator therapy. N Engl J Med. 2007;357(26):2657–65. https://doi.org/10.1056/NEJMoa065457.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Kuck KH, Schaumann A, Eckardt L, Willems S, Ventura R, Delacrétaz E, et al. Catheter ablation of stable ventricular tachycardia before defibrillator implantation in patients with coronary heart disease (VTACH): a multicenter randomised controlled trial. Lancet. 2010;375(9708):31–40. https://doi.org/10.1016/S0140-6736(09)61755-4.

    Article  PubMed  Google Scholar 

  50. Liang JJ, Muser D, Santangeli P. Ventricular tachycardia ablation clinical trials. Card Electrophysiol Clin. 2017;9(1):153–65. https://doi.org/10.1016/j.ccep.2016.10.012.

    Article  PubMed  Google Scholar 

  51. Haegeli LM, Della Bella P, Brunckhorst CB. Management of a patient with electrical storm, role of epicardial catheter ablation. Circulation. 2016;133(7):672–6. https://doi.org/10.1161/CIRCULATIONAHA.115.016336.

    Article  PubMed  Google Scholar 

  52. Ajijola OA, Lellouche N, Bourke T, Tung R, Ahn S, Mahajan A, et al. Bilateral cardiac sympathetic denervation for the management of electrical storm. J Am Coll Cardiol. 2012;59(1):91–2. https://doi.org/10.1016/j.jacc.2011.09.043.

    Article  PubMed  PubMed Central  Google Scholar 

  53. Vaseghi M, Gima J, Kanaan C, Ajijola OA, Marmureanu A, Mahajan A, et al. Cardiac sympathetic denervation in patients with refractory ventricular arrhythmias or electrical storm: intermediate and long-term follow-up. Heart Rhythm. 2014;11(3):360–6. https://doi.org/10.1016/j.hrthm.2013.11.028.

    Article  PubMed  Google Scholar 

  54. • Vaseghi M, Barwad P, MalavassiCorrales FJ, Tandri H, Mathuria N, Shah R, et al. Cardiac sympathetic denervation for refractory ventricular arrhythmias. J Am Coll Cardiol. 2017;69(25):3070–80. https://doi.org/10.1016/j.jacc.2017.04 The largest series of patients with refractory ventricular arrhythmias undergoing cardiac sympathetic denervation highlights the adjunctive role of this approach in patients with electrical storm.

    Article  PubMed  PubMed Central  Google Scholar 

  55. Do DH, Bradfield J, Ajijola OA, Vaseghi M, Le J, Rahman S, et al. Thoracic epidural anesthesia can be effective for the short-term management of ventricular tachycardia storm. J Am Heart Assoc. 20176(11). pii: e007080. doi: https://doi.org/10.1161/JAHA.117.007080.

  56. Bourke T, Vaseghi M, Michowitz Y, Sankhla V, Shah M, Swapna N, et al. Neuraxial modulation for refractory ventricular arrhythmias: value of thoracic epidural anesthesia and surgical left cardiac sympathetic denervation. Circulation. 2010;121(21):2255–62. https://doi.org/10.1161/CIRCULATIONAHA.109.929703.

    Article  PubMed  PubMed Central  Google Scholar 

  57. Fudim M, Boortz-Marx R, Ganesh A, Waldron NH, Qadri YJ, Patel CB, et al. Stellate ganglion blockade for the treatment of refractory ventricular arrhythmias: a systematic review and meta-analysis. Cardiovasc Electrophysiol. 2017;28(12):1460–7. https://doi.org/10.1111/jce.13324.

    Article  Google Scholar 

  58. Remo BF, Preminger M, Bradfield J, Mittal S, Boyle N, Gupta A, et al. Safety and efficacy of renal denervation as a novel treatment of ventricular tachycardia storm in patients with cardiomyopathy. Heart Rhythm. 2014;11(4):541–6. https://doi.org/10.1016/j.hrthm.2013.12.038.

    Article  PubMed  Google Scholar 

  59. Antzelevitch C, Yan GX, Ackerman MJ, Borggrefe M, Corrado D, Guo J, et al. J-wave syndromes expert consensus conference report: emerging concepts and gaps in knowledge. J Arrhythm. 2016;32(5):315–39. https://doi.org/10.1016/j.joa.2016.07.002.

    Article  PubMed  PubMed Central  Google Scholar 

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Christos Kontogiannis, Konstantinos Tampakis, Georgios Georgiopoulos, Stefano Bartoletti, Christos Papageorgiou, Hector Anninos, Alkistis Kapelouzou, Michael Spartalis, Ioannis Paraskevaidis, and Sofia Chatzidou declare that they have no conflict of interest.

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Kontogiannis, C., Tampakis, K., Georgiopoulos, G. et al. Electrical Storm: Current Evidence, Clinical Implications, and Future Perspectives. Curr Cardiol Rep 21, 96 (2019). https://doi.org/10.1007/s11886-019-1190-0

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