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Skeletal Muscle Myopathy in Heart Failure: the Role of Ejection Fraction

  • Myocardial Disease (A Abbate, Section Editor)
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Abstract

Purpose of Review

This review summarizes: (1) the structural and functional features coupled with pathophysiological factors responsible of skeletal muscle myopathy (SMM) in both heart failure with reduced (HFrEF) and preserved (HFpEF) ejection fraction and (2) the role of exercise as treatment of SMM in these HF-related phenotypes.

Recent Findings

The recent literature showed two main phenotypes of heart failure (HF): (1) HFrEF primarily due to a systolic dysfunction of the left ventricle and (2) HFpEF, mainly related to a diastolic dysfunction. Exercise intolerance is one of most disabling symptoms of HF and it is shown that persists after the normalization of the central hemodynamic impairments by therapy and/or cardiac surgery including heart transplant. A specific skeletal muscle myopathy (SMM) has been defined as one of the main causes of exercise intolerance in HF.

Summary

The SMM has been well described in the last 20 years in the HFrEF; on the contrary, few studies are available in HFpEF. Recent evidences have revealed that exercise training counteracts HF-related SMM and in turn ameliorates exercise intolerance.

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Authors and Affiliations

  1. Istituti Clinici Scientifici Maugeri, IRCCS, Pavia, Italy

    Mara Paneroni, Evasio Pasini, Laura Comini, Michele Vitacca & Simonetta Scalvini

  2. Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Via Casorati 43, 37100, Verona, Italy

    Federico Schena & Massimo Venturelli

  3. Division of Geriatrics, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA

    Massimo Venturelli

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  1. Mara Paneroni
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  2. Evasio Pasini
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  3. Laura Comini
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Mara Paneroni, Evasio Pasini, Laura Comini, Michele Vitacca, Federico Schena, Simonetta Scalvini, and Massimo Venturelli declare that they have no conflict of interest.

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This article is part of the Topical Collection on Myocardial Disease

Paneroni Mara and Pasini Evasio equally contribute to this review.

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Paneroni, M., Pasini, E., Comini, L. et al. Skeletal Muscle Myopathy in Heart Failure: the Role of Ejection Fraction. Curr Cardiol Rep 20, 116 (2018). https://doi.org/10.1007/s11886-018-1056-x

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