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Management of Chronic Bacteriuria in Neurogenic Bladders

  • Inflammatory/Infectious Bladder Disorders (MS Mourad, Section Editor)
  • Published:
Current Bladder Dysfunction Reports Aims and scope Submit manuscript

Abstract

Purpose of the Review

Lower urinary tract dysfunction is a major cause of morbidity in patients with neurogenic conditions. One of the significant issues in this group is urinary tract infections. In this review, the causes of bacteriuria along with the symptoms, diagnosis, prevention and treatment options will be discussed.

Recent Findings

As in other areas of neuro-urology there is a lack of randomized controlled trials in this field. Most of the evidence is from retrospective cohort studies. Nonetheless, there are a number of guidelines and consensus statements from international organizations to standardize the treatment of recurrent urinary infections in this complex group of patients.

Summary

The management of recurrent urinary infections symptoms in neurogenic patients is challenging as these patients do not always exhibit classical signs and symptoms. The evidence base is not so strong for treatment pathways. We need structured randomized control studies to better understand and manage this complex condition in this cohort of patients.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Vigil HR, Hickling DR. Urinary tract infection in the neurogenic bladder. Transl Androl Urol. 2016;5(1):72–87.

    PubMed  PubMed Central  Google Scholar 

  2. Esclarín De Ruz A, García Leoni E, Herruzo Cabrera R. Epidemiology and risk factors for urinary tract infection in patients with spinal cord injury. J Urol. 2000;164(4):1285–9.

    PubMed  Google Scholar 

  3. Biering-Sørensen F, Bagi P, Høiby N. Urinary tract infections in patients with spinal cord lesions: treatment and prevention. Drugs. 2001;61(9):1275–87.

    PubMed  Google Scholar 

  4. Hinkel A, Finke W, Bötel U, Gatermann SG, Pannek J. Increasing resistance against antibiotics in bacteria isolated from the lower urinary tract of an outpatient population of spinal cord injury patients. Urol Int. 2004;73(2):143–8.

    CAS  PubMed  Google Scholar 

  5. Gamé X, Castel-Lacanal E, Bentaleb Y, Thiry-Escudié I, De Boissezon X, Malavaud B, et al. Botulinum toxin A detrusor injections in patients with neurogenic detrusor overactivity significantly decrease the incidence of symptomatic urinary tract infections. Eur Urol. 2008;53(3):613–8.

    PubMed  Google Scholar 

  6. Vasudeva P, Madersbacher H. Factors implicated in pathogenesis of urinary tract infections in neurogenic bladders: some revered, few forgotten, others ignored. Neurourol Urodyn. 2014;33(1):95–100.

    PubMed  Google Scholar 

  7. Devillé WL, Yzermans JC, van Duijn NP, Bezemer PD, van der Windt DA, Bouter LM. The urine dipstick test useful to rule out infections. A meta-analysis of the accuracy. BMC Urol. 2004;4:4.

    PubMed  PubMed Central  Google Scholar 

  8. Hoffman JM, Wadhwani R, Kelly E, Dixit B, Cardenas DD. Nitrite and leukocyte dipstick testing for urinary tract infection in individuals with spinal cord injury. J Spinal Cord Med. 2004;27(2):128–32.

    PubMed  Google Scholar 

  9. •• Blok B, Castro-Diaz G, Del Popolo G, Groen J, Hamid R, Karsenty G, et al. EAU Guidelines on Neuro-Urology 2020. European Association of Urology Guidelines 2020 Edition. presented at the EAU Annual Congress Amsterdam 2020. Arnhem, the Netherlands: European Association of Urology guidelines office; 2020. The most up todate and comprehensive guidelines.

  10. Groen J, Pannek J, Castro Diaz D, Del Popolo G, Gross T, Hamid R, et al. Summary of European Association of Urology (EAU) guidelines on neuro-urology. Eur Urol. 2016;69(2):324–33.

    PubMed  Google Scholar 

  11. •• Pannek J, Wöllner J. Management of urinary tract infections in patients with neurogenic bladder: challenges and solutions. Res Rep Urol. 2017;9:121–7. The paper highlights the complexity in managing infections in patients with neurogenic bladders.

    CAS  PubMed  PubMed Central  Google Scholar 

  12. Goetz LL, Cardenas DD, Kennelly M, Bonne Lee BS, Linsenmeyer T, Moser C, et al. International spinal cord injury urinary tract infection basic data set. Spinal Cord. 2013;51(9):700–4.

    CAS  PubMed  Google Scholar 

  13. Hooton TM, Bradley SF, Cardenas DD, Colgan R, Geerlings SE, Rice JC, et al. Diagnosis, prevention, and treatment of catheter-associated urinary tract infection in adults: 2009 International Clinical Practice Guidelines from the Infectious Diseases Society of America. Clin Infect Dis. 2010;50(5):625–63.

    PubMed  Google Scholar 

  14. The prevention and management of urinary tract infections among people with spinal cord injuries. National Institute on Disability and Rehabilitation Research consensus statement. January 27-29, 1992. SCI Nurs. 1993;10(2):49–61.

  15. Lee H, Lee YS, Im YJ, Han SW. Vesicoureteral reflux and bladder dysfunction. Transl Androl Urol. 2012;1(3):153–9.

    PubMed  PubMed Central  Google Scholar 

  16. Cameron AP, Rodriguez GM, Schomer KG. Systematic review of urological followup after spinal cord injury. J Urol. 2012;187(2):391–7.

    PubMed  Google Scholar 

  17. Przydacz M, Chlosta P, Corcos J. Recommendations for urological follow-up of patients with neurogenic bladder secondary to spinal cord injury. Int Urol Nephrol. 2018;50(6):1005–16.

    PubMed  Google Scholar 

  18. Hamid R, Bycroft J, Arya M, Shah PJ. Screening cystoscopy and biopsy in patients with neuropathic bladder and chronic suprapubic indwelling catheters: is it valid? J Urol. 2003;170(2 Pt 1):425–7.

    CAS  PubMed  Google Scholar 

  19. •• Kreydin E, Welk B, Chung D, Clemens Q, Yang C, Danforth T, et al. Surveillance and management of urologic complications after spinal cord injury. World J Urol. 2018;36(10):1545–53. This study highlights the importance for long-term follow-up of SCI patients to proactively detect and treat urological complications.

    PubMed  Google Scholar 

  20. Massa LM, Hoffman JM, Cardenas DD. Validity, accuracy, and predictive value of urinary tract infection signs and symptoms in individuals with spinal cord injury on intermittent catheterization. J Spinal Cord Med. 2009;32(5):568–73.

    PubMed  PubMed Central  Google Scholar 

  21. Desai DG, Liao KS, Cevallos ME, Trautner BW. Silver or nitrofurazone impregnation of urinary catheters has a minimal effect on uropathogen adherence. J Urol. 2010;184(6):2565–71.

    CAS  PubMed  PubMed Central  Google Scholar 

  22. Jacobsen SM, Stickler DJ, Mobley HL, Shirtliff ME. Complicated catheter-associated urinary tract infections due to Escherichia coli and Proteus mirabilis. Clin Microbiol Rev. 2008;21(1):26–59.

    CAS  PubMed  PubMed Central  Google Scholar 

  23. Murugan K, Selvanayaki K, Al-Sohaibani S. Urinary catheter indwelling clinical pathogen biofilm formation, exopolysaccharide characterization and their growth influencing parameters. Saudi J Biol Sci. 2016;23(1):150–9.

    CAS  PubMed  Google Scholar 

  24. Saint S, Chenoweth CE. Biofilms and catheter-associated urinary tract infections. Infect Dis Clin N Am. 2003;17(2):411–32.

    Google Scholar 

  25. Jung JH, Choi NY, Lee SY. Biofilm formation and exopolysaccharide (EPS) production by Cronobacter sakazakii depending on environmental conditions. Food Microbiol. 2013;34(1):70–80.

    CAS  PubMed  Google Scholar 

  26. Brady RA, O'May GA, Leid JG, Prior ML, Costerton JW, Shirtliff ME. Resolution of Staphylococcus aureus biofilm infection using vaccination and antibiotic treatment. Infect Immun. 2011;79(4):1797–803.

    CAS  PubMed  PubMed Central  Google Scholar 

  27. Moscoso M, García E, López R. Pneumococcal biofilms. Int Microbiol. 2009;12(2):77–85.

    CAS  PubMed  Google Scholar 

  28. Warren JW, Platt R, Thomas RJ, Rosner B, Kass EH. Antibiotic irrigation and catheter-associated urinary-tract infections. N Engl J Med. 1978;299(11):570–3.

    CAS  PubMed  Google Scholar 

  29. Platt R, Polk BF, Murdock B, Rosner B. Reduction of mortality associated with nosocomial urinary tract infection. Lancet. 1983;1(8330):893–7.

    CAS  PubMed  Google Scholar 

  30. Siddiq DM, Darouiche RO. New strategies to prevent catheter-associated urinary tract infections. Nat Rev Urol. 2012;9(6):305–14.

    CAS  PubMed  Google Scholar 

  31. Hartstein AI, Garber SB, Ward TT, Jones SR, Morthland VH. Nosocomial urinary tract infection: a prospective evaluation of 108 catheterized patients. Infect Control. 1981;2(5):380–6.

    CAS  PubMed  Google Scholar 

  32. Tenney JH, Warren JW. Bacteriuria in women with long-term catheters: paired comparison of indwelling and replacement catheters. J Infect Dis. 1988;157(1):199–202.

    CAS  PubMed  Google Scholar 

  33. Grahn D, Norman DC, White ML, Cantrell M, Yoshikawa TT. Validity of urinary catheter specimen for diagnosis of urinary tract infection in the elderly. Arch Intern Med. 1985;145(10):1858–60.

    CAS  PubMed  Google Scholar 

  34. Siroky MB. Pathogenesis of bacteriuria and infection in the spinal cord injured patient. Am J Med. 2002;113(Suppl 1A):67S–79S.

    PubMed  Google Scholar 

  35. Mitsui T, Minami K, Furuno T, Morita H, Koyanagi T. Is suprapubic cystostomy an optimal urinary management in high quadriplegics?. A comparative study of suprapubic cystostomy and clean intermittent catheterization. Eur Urol. 2000;38(4):434–8.

    CAS  PubMed  Google Scholar 

  36. Montgomerie JZ, Gilmore DS, Graham IE, Schick DG, Ashley MA, Morrow JW, et al. Klebsiella pneumoniae colonization in patients with spinal cord injury. Diagn Microbiol Infect Dis. 1987;7(4):229–35.

    CAS  PubMed  Google Scholar 

  37. Montgomerie JZ, Morrow JW. Long-term Pseudomonas colonization in spinal cord injury patients. Am J Epidemiol. 1980;112(4):508–17.

    CAS  PubMed  Google Scholar 

  38. Reiche T, Lisby G, Jørgensen S, Christensen AB, Nordling J. A prospective, controlled, randomized study of the effect of a slow-release silver device on the frequency of urinary tract infection in newly catheterized patients. BJU Int. 2000;85(1):54–9.

    CAS  PubMed  Google Scholar 

  39. Thompson RL, Haley CE, Searcy MA, Guenthner SM, Kaiser DL, Gröschel DH, et al. Catheter-associated bacteriuria. Failure to reduce attack rates using periodic instillations of a disinfectant into urinary drainage systems. JAMA. 1984;251(6):747–51.

    CAS  PubMed  Google Scholar 

  40. Davies AJ, Desai HN, Turton S, Dyas A. Does instillation of chlorhexidine into the bladder of catheterized geriatric patients help reduce bacteriuria? J Hosp Infect. 1987;9(1):72–5.

    CAS  PubMed  Google Scholar 

  41. Dudley MN, Barriere SL. Antimicrobial irrigations in the prevention and treatment of catheter-related urinary tract infections. Am J Hosp Pharm. 1981;38(1):59–65.

    CAS  PubMed  Google Scholar 

  42. Prieto J, Murphy CL, Moore KN, Fader M. Intermittent catheterisation for long-term bladder management. Cochrane Database Syst Rev. 2014;9:CD006008.

    Google Scholar 

  43. Salameh A, Mohajer MA, Daroucihe RO. Prevention of urinary tract infections in patients with spinal cord injury. CMAJ. 2015;187(11):807–11.

    PubMed  PubMed Central  Google Scholar 

  44. Morton SC, Shekelle PG, Adams JL, Bennett C, Dobkin BH, Montgomerie J, et al. Antimicrobial prophylaxis for urinary tract infection in persons with spinal cord dysfunction. Arch Phys Med Rehabil. 2002;83(1):129–38.

    PubMed  Google Scholar 

  45. Niël-Weise BS, van den Broek PJ, da Silva EM, Silva LA. Urinary catheter policies for long-term bladder drainage. Cochrane Database Syst Rev. 2012;8:CD004201.

    Google Scholar 

  46. Salomon J, Denys P, Merle C, Chartier-Kastler E, Perronne C, Gaillard JL, et al. Prevention of urinary tract infection in spinal cord-injured patients: safety and efficacy of a weekly oral cyclic antibiotic (WOCA) programme with a 2 year follow-up--an observational prospective study. J Antimicrob Chemother. 2006;57(4):784–8.

    CAS  PubMed  Google Scholar 

  47. Poirier C, Dinh A, Salomon J, Grall N, Andremont A, Bernard L. Prevention of urinary tract infections by antibiotic cycling in spinal cord injury patients and low emergence of multidrug resistant bacteria. Med Mal Infect. 2016;46(6):294–9.

    CAS  PubMed  Google Scholar 

  48. Chong JT, Klausner AP, Petrossian A, Byrne MD, Moore JR, Goetz LL, et al. Pre-procedural antibiotics for endoscopic urological procedures: initial experience in individuals with spinal cord injury and asymptomatic bacteriuria. J Spinal Cord Med. 2015;38(2):187–92.

    PubMed  PubMed Central  Google Scholar 

  49. Böthig R, Fiebag K, Thietje R, Faschingbauer M, Hirschfeld S. Morbidity of urinary tract infection after urodynamic examination of hospitalized SCI patients: the impact of bladder management. Spinal Cord. 2013;51(1):70–3.

    PubMed  Google Scholar 

  50. • Nadeem M, Sheikh MI, Sait M, Emmanuel N, Sheriff M, Masood S. Is urinary tract infection after urodynamic study predictable? Urol Sci. 2017;28(4):240–2. An important study looking at UTI after an almost must investigation in neurogenic population.

  51. • Toh SL, Lee BB, Ryan S, Simpson JM, Clezy K, Bossa L, et al. Probiotics [LGG-BB12 or RC14-GR1] versus placebo as prophylaxis for urinary tract infection in persons with spinal cord injury [ProSCIUTTU]: a randomised controlled trial. Spinal Cord. 2019;57(7):550–61. A inteesting prospective study for prophylaxis with Probiotics in UTI.

  52. Opperman EA. Cranberry is not effective for the prevention or treatment of urinary tract infections in individuals with spinal cord injury. Spinal Cord. 2010;48(6):451–6.

    CAS  PubMed  Google Scholar 

  53. •• EAU Guidelines on Neuro-Urology. 2020. The most respected Guidelines in urology.

  54. Gallien P, Amarenco G, Benoit N, Bonniaud V, Donzé C, Kerdraon J, et al. Cranberry versus placebo in the prevention of urinary infections in multiple sclerosis: a multicenter, randomized, placebo-controlled, double-blind trial. Mult Scler. 2014;20(9):1252–9.

    PubMed  Google Scholar 

  55. Howell A, Souza D, Roller M, Fromentin E. Comparison of the anti-adhesion activity of three different cranberry extracts on uropathogenic P-fimbriated Escherichia coli: a randomized, double-blind, placebo controlled, ex vivo, acute study. Nat Prod Commun. 2015;10(7):1215–8.

    PubMed  Google Scholar 

  56. Hess MJ, Hess PE, Sullivan MR, Nee M, Yalla SV. Evaluation of cranberry tablets for the prevention of urinary tract infections in spinal cord injured patients with neurogenic bladder. Spinal Cord. 2008;46(9):622–6.

    CAS  PubMed  Google Scholar 

  57. Wellens A, Garofalo C, Nguyen H, Van Gerven N, Slättegård R, Hernalsteens JP, et al. Intervening with urinary tract infections using anti-adhesives based on the crystal structure of the FimH-oligomannose-3 complex. PLoS One. 2008;3(4):e2040.

    PubMed  PubMed Central  Google Scholar 

  58. • Phé V, Pakzad M, Haslam C, Gonzales G, Curtis C, Porter B, et al. Open label feasibility study evaluating D-mannose combined with home-based monitoring of suspected urinary tract infections in patients with multiple sclerosis. Neurourol Urodyn. 2017;36(7):1770–5. An interesting study looking at alternative management therapies than antibiotics to treat infections.

    PubMed  Google Scholar 

  59. • Hollyer I, Varias F, Ho B, Ison MG. Safety and efficacy of methenamine hippurate for the prevention of recurrent urinary tract infections in adult renal transplant recipients: a single center, retrospective study. Transpl Infect Dis. 2019;21(3):e13063. An interesting study looking at alternative management therapies than antibiotics to treat infections.

    PubMed  PubMed Central  Google Scholar 

  60. Lee BS, Bhuta T, Simpson JM, Craig JC. Methenamine hippurate for preventing urinary tract infections. Cochrane Database Syst Rev. 2012;10:CD003265.

    PubMed  Google Scholar 

  61. • Huttner A, Hatz C, van den Dobbelsteen G, Abbanat D, Hornacek A, Frölich R, et al. Safety, immunogenicity, and preliminary clinical efficacy of a vaccine against extraintestinal pathogenic Escherichia coli in women with a history of recurrent urinary tract infection: a randomised, single-blind, placebo-controlled phase 1b trial. Lancet Infect Dis. 2017;17(5):528–37. An interesting study looking at alternative management therapies than antibiotics to treat infections.

    CAS  PubMed  Google Scholar 

  62. Hachen HJ. Oral immunotherapy in paraplegic patients with chronic urinary tract infections: a double-blind, placebo-controlled trial. J Urol. 1990;143(4):759–62 discussion 62-3.

    CAS  PubMed  Google Scholar 

  63. Darouiche RO, Green BG, Donovan WH, Chen D, Schwartz M, Merritt J, et al. Multicenter randomized controlled trial of bacterial interference for prevention of urinary tract infection in patients with neurogenic bladder. Urology. 2011;78(2):341–6.

    PubMed  Google Scholar 

  64. Horwitz D, McCue T, Mapes AC, Ajami NJ, Petrosino JF, Ramig RF, et al. Decreased microbiota diversity associated with urinary tract infection in a trial of bacterial interference. J Inf Secur. 2015;71(3):358–67.

    Google Scholar 

  65. Iavazzo C, Athanasiou S, Pitsouni E, Falagas ME. Hyaluronic acid: an effective alternative treatment of interstitial cystitis, recurrent urinary tract infections, and hemorrhagic cystitis? Eur Urol. 2007;51(6):1534–40 discussion 40-1.

    CAS  PubMed  Google Scholar 

  66. • Dutta S, Lane F. Intravesical instillations for the treatment of refractory recurrent urinary tract infections. Ther Adv Urol. 2018;10(5):157–63. An interesting study looking at alternative management therapies than antibiotics to treat infections.

    CAS  PubMed  PubMed Central  Google Scholar 

  67. •• Pannek J, Pannek-Rademacher S, Jus MS, Wöllner J, Krebs J. Usefulness of classical homeopathy for the prophylaxis of recurrent urinary tract infections in individuals with chronic neurogenic lower urinary tract dysfunction. J Spinal Cord Med. 2019;42(4):453–9. Appliation of classical homeopathy in prophylaxis.

  68. Pannek J, Pannek-Rademacher S, Wöllner J. Use of complementary and alternative medicine in persons with spinal cord injury in Switzerland: a survey study. Spinal Cord. 2015;53(7):569–72.

    CAS  PubMed  Google Scholar 

  69. Christensen P, Bazzocchi G, Coggrave M, Abel R, Hultling C, Krogh K, et al. A randomized, controlled trial of transanal irrigation versus conservative bowel management in spinal cord-injured patients. Gastroenterology. 2006;131(3):738–47.

    PubMed  Google Scholar 

  70. Everaert K, Lumen N, Kerckhaert W, Willaert P, van Driel M. Urinary tract infections in spinal cord injury: prevention and treatment guidelines. Acta Clin Belg. 2009;64(4):335–40.

    CAS  PubMed  Google Scholar 

  71. Darouiche RO, Al Mohajer M, Siddiq DM, Minard CG. Short versus long course of antibiotics for catheter-associated urinary tract infections in patients with spinal cord injury: a randomized controlled noninferiority trial. Arch Phys Med Rehabil. 2014;95(2):290–6.

    PubMed  Google Scholar 

  72. Dinh A, Toumi A, Blanc C, Descatha A, Bouchand F, Salomon J, et al. Management of febrile urinary tract infection among spinal cord injured patients. BMC Infect Dis. 2016;16:156.

    PubMed  PubMed Central  Google Scholar 

  73. Rahimi F, Shokoohizadeh L. Characterization of methicillin resistant Staphylococcus aureus strains among inpatients and outpatients in a referral hospital in Tehran, Iran. Microb Pathog. 2016;97:89–93.

    CAS  PubMed  Google Scholar 

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Correspondence to Rizwan Hamid.

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Mehwash Nadeem reports no conflict of interest.

Rizwan Hamid is trial investigators for Allergan. He is a consultant for Allergan, Coloplast and Contura outside the submitted work.

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Nadeem, M., Hamid, R. Management of Chronic Bacteriuria in Neurogenic Bladders. Curr Bladder Dysfunct Rep 15, 332–339 (2020). https://doi.org/10.1007/s11884-020-00611-2

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