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Olfaction in Chronic Rhinosinusitis

  • Rhinosinusitis (J Mullol, Section Editor)
  • Published:
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Abstract

Olfactory dysfunction is a frequent complaint in chronic rhinosinusitis patients and has a significant impact on quality of life. Therefore, it is essential that clinicians are aware of the importance of olfactory dysfunction in chronic rhinosinusitis (CRS) patients and know how to deal with it. Notably, the evaluation of olfactory function (i.e., using psychophysical testing) and imagery of olfactory bulb play an important role in the evaluation of patients and give essential information about the “baseline” olfactory function. Because the high impact of olfactory function on quality of life and medical and/or surgical treatment should be proposed to patients. However, it remains difficult to predict the outcome of treatment as well as long-term efficacy. The first section of this review is dedicated to the assessment of olfactory function. Secondly, we will discuss the etiopathology of olfactory dysfunction in CRS with and without nasal polyps. Finally, we will review literature findings about the efficacy of different treatments on olfactory function.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Landis BN, Konnerth CG, Hummel T. A study on the frequency of olfactory dysfunction. Laryngoscope. 2004;114(10):1764–9.

    Article  CAS  PubMed  Google Scholar 

  2. Mullol J, Alobid I, Mariño-Sánchez F, Quintó L, de Haro J, Bernal-Sprekelsen M, et al. Furthering the understanding of olfaction, prevalence of loss of smell and risk factors: a population-based survey (OLFACAT study). BMJ Open. 2012;2(6):e001256.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Fonteyn S, Huart C, Deggouj N, Collet S, Eloy P, Rombaux P. Non-sinonasal-related olfactory dysfunction: a cohort of 496 patients. Eur Ann Otorhinolaryngol Head Neck Dis. 2014;131(2):87–91.

    Article  CAS  PubMed  Google Scholar 

  4. Frasnelli J, Hummel T. Olfactory dysfunction and daily life. Eur Arch Otorhinolaryngol: Off J Eur Fed Otorhinolaryngol Soc. 2005;262(3):231–5.

    Article  Google Scholar 

  5. Neuland C, Bitter T, Marschner H, Gudziol H, Guntinas-Lichius O. Health-related and specific olfaction-related quality of life in patients with chronic functional anosmia or severe hyposmia. Laryngoscope. 2011;121(4):867–72.

    Article  PubMed  Google Scholar 

  6. Deems DA, Doty RL, Settle RG, Moore-Gillon V, Shaman P, Mester AF, et al. Smell and taste disorders, a study of 750 patients from the University of Pennsylvania Smell and Taste Center. Arch Otolaryngol Head Neck Surg. 1991;117(5):519–28.

    Article  CAS  PubMed  Google Scholar 

  7. Doty RL, Shaman P, Kimmelman CP, Dann MS. University of Pennsylvania Smell Identification Test: a rapid quantitative olfactory function test for the clinic. Laryngoscope. 1984;94(2 Pt1):176–8.

    Article  CAS  PubMed  Google Scholar 

  8. Doty RL, Shaman P, Dann M. Development of the University of Pennsylvania Smell Identification Test: a standardized microencapsulated test of olfactory function. Physiol Behav. 1984;32(3):489–502.

    Article  CAS  PubMed  Google Scholar 

  9. Doty RL, Marcus A, Lee WW. Development of the 12-item cross-cultural smell identification test (CC-SIT). Laryngoscope. 1996;106(3Pt1):353–6.

    Article  CAS  PubMed  Google Scholar 

  10. Hummel T, Sekinger B, Wolf SR, Pauli E, Kobal G. ‘Sniffin’ sticks’: olfactory performance assessed by the combined testing of odor identification, odor discrimination and olfactory threshold. Chem Senses. 1997;22(1):39–52.

    Article  CAS  PubMed  Google Scholar 

  11. Hummel T, Konnerth CG, Rosenheim K, Kobal G. Screening of olfactory function with a four-minute odor identification test: reliability, normative data, and investigations in patient with olfactory loss. Ann Otol Rhinol Laryngol. 2001;110(10):976–81.

    Article  CAS  PubMed  Google Scholar 

  12. Thomas-Danguin T, Rouby C, Sicard G, et al. Development of the ETOC: a European test of olfactory capabilities. Rhinology. 2003;41(3):142–51.

    PubMed  Google Scholar 

  13. Cain WS, Gent JFn Goodspeed RB, Leonard G. Evaluation of the olfactory dysfunction in the Connecticut Chemosensory Clinical Research Center. Laryngoscope. 1988;98(1):83–8.

    Article  CAS  PubMed  Google Scholar 

  14. Cardesin A, Alobid I, Benitez P, Sierra E, de Haro J, Bernal-Sprekelsen M, et al. Barcelona Smell Test-24 (BAST-24): validation and smell characteristics in the healthy Spanish population. Rhinology. 2006;44(1):83–9.

    PubMed  Google Scholar 

  15. Briner HR, Simmen D. Smell diskettes as screening test of olfaction. Rhinology. 1999;37:145–8.

    CAS  PubMed  Google Scholar 

  16. Kondo H, Matsuda T, Hashiba M, Baba S. A study of the relationship between the T & T olfactometer and the University of Pennsylvania Smell Identification Test in a Japanese population. Am J Rhinol. 1998;12(5):353–8.

    Article  CAS  PubMed  Google Scholar 

  17. Heilmann S, Strehle G, Rosenheim K, Damm M, Hummel T. Clinical assessment of retronasal olfactory function. Arch Otolaryngol Head Neck Surg. 2002;128(4):414–8.

    Article  PubMed  Google Scholar 

  18. Lapid H, Hummel T. Recording odor-evoked response potentials at the human olfactory epithelium. Chem Senses. 2013;38(1):3–17.

    Article  PubMed  Google Scholar 

  19. Hummel T, Kobal G. Olfactory event-related potentials. In: Simon SA, Nicolelis MAL, editors. Methods and frontiers in chemosensory research. Boca Raton: CRC press; 2001. p. 429–64.

    Google Scholar 

  20. Kobal G, Plattig KH. Methodische Anmerkungen zur Gewinnung olfaktorischer EEG-Antworten des wachen Menschen (objektive Olfaktometrie). Z EEG-EMG. 1978;9:135–45.

    CAS  Google Scholar 

  21. Kobal G. Elektrophysiologische Untersuchungen des menschlichen Geruchssinns. Stuttgart: Thieme Verlag; 1981.

    Google Scholar 

  22. Huart C, Rombaux P, Hummel T. Plasticity of the human olfactory system: the olfactory bulb. Molecules. 2013;18(9):11586–600.

    Article  CAS  PubMed  Google Scholar 

  23. Gudziol V, Buschhuter D, Abolmaali N, Gerber J, Rombaux P, Hummel T. Increasing olfactory bulb volume due to treatment of chronic rhinosinusitis—a longitudinal study. Brain J Neurol. 2009;132(Pt 11):3096–101. Positive effect of surgery on the olfactory bulb volume. This paper summarizes the actual findings in relation to olfaction in chronic rhinosinusitis.

  24. Holbrook EH, Leopold DA. An updated review of clinical olfaction. Curr Opin Otolaryngol Head Neck Surg. 2006;14(1):23–8.

    Article  PubMed  Google Scholar 

  25. Mott AE, Leopold DA. Disorders in taste and smell. Med Clin North Am. 1991;75(6):1321–53.

    Article  CAS  PubMed  Google Scholar 

  26. Raviv JR, Kern RC. Chronic sinusitis and olfactory dysfunction. Otolaryngol Clin N Am. 2004;37(6):1143–57. v-vi.

    Article  Google Scholar 

  27. Seiden AM, Duncan HJ. The diagnosis of a conductive olfactory loss. Laryngoscope. 2001;111(1):9–14.

    Article  CAS  PubMed  Google Scholar 

  28. Bhattacharyya N. The economic burden and symptom manifestations of chronic rhinosinusitis. Am J Rhinol. 2003;17(1):27–32.

    PubMed  Google Scholar 

  29. Litvack JR, Fong K, Mace J, James KE, Smith TL. Predictors of olfactory dysfunction in patients with chronic rhinosinusitis. Laryngoscope. 2008;118(12):2225–30. Clinical signs of olfactory dysfunction in CRS patients. This paper summarizes the actual findings in relation to olfaction in chronic rhinosinusitis.

  30. Orlandi RR, Terrell JE. Analysis of the adult chronic rhinosinusitis working definition. Am J Rhinol. 2002;16(1):7–10.

    PubMed  Google Scholar 

  31. Soler ZM, Mace J, Smith TL. Symptom-based presentation of chronic rhinosinusitis and symptom-specific outcomes after endoscopic sinus surgery. Am J Rhinol. 2008;22(3):297–301.

    Article  PubMed  Google Scholar 

  32. Nordin S, Monsch AU, Murphy C. Unawareness of smell loss in normal aging and Alzheimer’s disease: discrepancy between self-reported and diagnosed smell sensitivity. J Gerontol Ser B Psychol Sci Soc Sci. 1995;50(4):P187–92.

    Article  CAS  Google Scholar 

  33. Welge-Luessen A. Psychophysical effects of nasal and oral inflammation. Ann N Y Acad Sci. 2009;1170:585–9.

    Article  PubMed  Google Scholar 

  34. Reden J, Maroldt H, Fritz A, Zahnert T, Hummel T. A study on the prognostic significance of qualitative olfactory dysfunction. Eur Arch Otorhinolaryngol: Off J Eur Fed Otorhinolaryngol Soc. 2007;264(2):139–44.

    Article  CAS  Google Scholar 

  35. Apter AJ, Gent JF, Frank ME. Fluctuating olfactory sensitivity and distorted odor perception in allergic rhinitis. Arch Otolaryngol Head Neck Surg. 1999;125(9):1005–10.

    Article  CAS  PubMed  Google Scholar 

  36. Alobid I, Cardelus S, Benítez P, Guilemany JM, Roca-Ferrer J, Picado C, et al. Persistent asthma has an accumulative impact on the loss of smell in patients with nasal polyposis. Rhinology. 2011;49(5):519–24.

    PubMed  Google Scholar 

  37. Guilemany JM, Mariño-Sánchez FS, Angrill J, Alobid I, Centellas S, Pujols L, et al. The importance of smell in patients with bronchiectasis. Respir Med. 2011;105(1):44–9.

    Article  PubMed  Google Scholar 

  38. Litvack JR, Mace JC, Smith TL. Olfactory function and disease severity in chronic rhinosinusitis. Am J Rhinol Allergy. 2009;23(2):139–44. Disease severity evaluated. This paper summarizes the actual findings in relation to olfaction in chronic rhinosinusitis.

  39. Alt JA, Mace JC, Buniel MC, Soler ZM, Smith TL. Predictors of olfactory dysfunction in rhinosinusitis using the brief smell identification test. Laryngoscope. 2014;124(7):E259–66. Practical use of olfactory testing. This paper summarizes the actual findings in relation to olfaction in chronic rhinosinusitis.

  40. Chang H, Lee HJ, Mo JH, Lee CH, Kim JW. Clinical implication of the olfactory cleft in patients with chronic rhinosinusitis and olfactory loss. Arch Otolaryngol Head Neck Surg. 2009;135(10):988–92. Olfactory cleft diseases and olfactory dysfunction. This paper summarizes the actual findings in relation to olfaction in chronic rhinosinusitis.

  41. Rombaux P, Potier H, Bertrand B, Duprez T, Hummel T. Olfactory bulb volume in patients with sinonasal disease. Am J Rhinol. 2008;22(6):598–601. Olfactory bulb volume in CRS patients. This paper summarizes the actual findings in relation to olfaction in chronic rhinosinusitis.

  42. Vento SI, Simola M, Ertama LO, Malmberg CH. Sense of smell in long-standing nasal polyposis. Am J Rhinol. 2001;15(3):159–63.

    Article  CAS  PubMed  Google Scholar 

  43. Mott AE, Cain WS, Lafreniere D, Leonard G, Gent JF, Frank ME. Topical corticosteroid treatment of anosmia associated with nasal and sinus disease. Arch Otolaryngol Head Neck Surg. 1997;123(4):367–72.

    Article  CAS  PubMed  Google Scholar 

  44. Reychler G, Colbrant C, Huart C, Le Guellec S, Vecellio L, Liistro G, et al. Effect of three-drug delivery modalities on olfactory function in chronic sinusitis. Laryngoscope. 2015;125(3):549–55.

    Article  CAS  PubMed  Google Scholar 

  45. Downey LL, Jacobs JB, Lebowitz RA. Anosmia and chronic sinus disease. Otolaryngol Head Neck Surg: Off J Am Acad Otolaryngol Head Neck Surg. 1996;115(1):24–8.

    Article  CAS  Google Scholar 

  46. Delank KW, Stoll W. Olfactory function after functional endoscopic sinus surgery for chronic sinusitis. Rhinology. 1998;36(1):15–9.

    CAS  PubMed  Google Scholar 

  47. Klimek L, Moll B, Amedee RG, Mann WJ. Olfactory function after microscopic endonasal surgery in patients with nasal polyps. Am J Rhinol. 1997;11(4):251–5.

    Article  CAS  PubMed  Google Scholar 

  48. Min YG, Yun YS, Song BH, Cho YS, Lee KS. Recovery of nasal physiology after functional endoscopic sinus surgery: olfaction and mucociliary transport. ORL J Otorhinolaryngol Relat Spec. 1995;57(5):264–8.

    Article  CAS  PubMed  Google Scholar 

  49. Briner HR, Jones N, Simmen D. Olfaction after endoscopic sinus surgery: long-term results. Rhinology. 2012;50(2):178–84.

    CAS  PubMed  Google Scholar 

  50. Oka H, Tsuzuki K, Takebayashi H, Kojima Y, Daimon T, Sakagami M. Olfactory changes after endoscopic sinus surgery in patients with chronic rhinosinusitis. Auris Nasus Larynx. 2013;40(5):452–7.

    Article  PubMed  Google Scholar 

  51. Litvack JR, Mace J, Smith TL. Does olfactory function improve after endoscopic sinus surgery? Otolaryngol Head Neck Surg: Off J Am Acad Otolaryngol Head Neck Surg. 2009;140(3):312–9.

    Article  Google Scholar 

  52. Vandenhende-Szymanski C, Hochet B, Chevalier D, Mortuaire G. Olfactory cleft opacity and CT score are predictive factors of smell recovery after surgery in nasal polyposis. Rhinology. 2015;53(1):29–34.

    CAS  PubMed  Google Scholar 

  53. Cantone E, Maione N, Di Rubbo V, Esposito F, Iengo M. Olfactory performance after crenotherapy in chronic rhinosinusitis in the elderly. Laryngoscope. 2015;125(7):1529–34.

    Article  PubMed  Google Scholar 

  54. Minwegen F, Thomas JP, Bernal-Sprekelsen M, Dazert S, Minovi A. Predictive value of disease severity on self-reported rating and quantitative measures of olfactory function outcomes after primary endoscopic sinus surgery. A prospective study. Rhinology. 2014;52(4):437–43.

    PubMed  Google Scholar 

  55. Kim DW, Kim JY, Kim SW, Jeon SY. Postoperative olfactory results in chronic rhinosinusitis with nasal polyposis according to wound healing status. Clin Exp Otorhinolaryngol. 2013;6(3):146–51.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  56. Hsu CY, Wang YP, Shen PH, Weitzel EK, Lai JT, Wormald PJ. Objective olfactory outcomes after revision endoscopic sinus surgery. Am J Rhinol Allergy. 2013;27(4):e96–100.

    Article  PubMed  Google Scholar 

  57. Baradaranfar MH, Ahmadi ZS, Dadgarnia MH, Bemanian MH, Atighechi S, Karimi G, et al. Comparison of the effect of endoscopic sinus surgery versus medical therapy on olfaction in nasal polyposis. Eur Arch Otorhinolaryngol. 2014;271(2):311–6. Comparison between medical and surgical therapies. This paper summarizes the actual findings in relation to olfaction in chronic rhinosinusitis.

  58. DeConde AS, Mace JC, Alt JA, Soler ZM, Orlandi RR, Smith TL. Investigation of change in cardinal symptoms of chronic rhinosinusitis after surgical or ongoing medical management. Int Forum Allergy Rhinol. 2015;5(1):36–45. Symptoms changes after surgery in olfactory dysfunction. This paper summarizes the actual findings in relation to olfaction in chronic rhinosinusitis.

  59. Doty RL, Frye R. Influence of nasal obstruction on smell function. Otolaryngol Clin N Am. 1989;22(2):397–411.

    CAS  Google Scholar 

  60. Kern RC. Chronic sinusitis and anosmia: pathologic changes in the olfactory mucosa. Laryngoscope. 2000;110(7):1071–7.

    Article  CAS  PubMed  Google Scholar 

  61. Naessen R. An enquiry on the morphological characteristics and possible changes with age in the olfactory region of man. Acta Otolaryngol. 1971;71(1):49–62.

    Article  CAS  PubMed  Google Scholar 

  62. Getchell ML, Mellert T. Olfactory mucus secretion. In: Getchell TV, Bartoshuk LM, Doty RL, Snow Jr JB, editors. Smell and taste in health and disease. New York: Raven; 1991. p. 83–95.

    Google Scholar 

  63. Hellings PW, Rombaux P. Medical therapy and smell dysfunction. B-ENT. 2009;5 Suppl 13:71–5.

    PubMed  Google Scholar 

  64. Joshi H, Getchell ML, Zielinski B, Getchell TV. Spectrophotometric determination of cation concentrations in olfactory mucus. Neurosci Lett. 1987;82(3):321–6.

    Article  CAS  PubMed  Google Scholar 

  65. Kern RC, Foster JD, Pitovski DZ. Glucocorticoid (type II) receptors in the olfactory mucosa of the guinea-pig: RU 28362. Chem Senses. 1997;22(3):313–9.

    Article  CAS  PubMed  Google Scholar 

  66. Apter AJ, Mott AE, Cain WS, Spiro JD, Barwick MC. Olfactory loss and allergic rhinitis. J Allergy Clin Immunol. 1992;90(4 Pt 1):670–80.

    Article  CAS  PubMed  Google Scholar 

  67. Calof AL, Hagiwara N, Holcomb JD, Mumm JS, Shou J. Neurogenesis and cell death in olfactory epithelium. J Neurobiol. 1996;30(1):67–81.

    Article  CAS  PubMed  Google Scholar 

  68. Calof AL, Holcomb JD, Mumm JS, Haglwara N, Tran P, Smith KM, et al. Factors affecting neuronal birth and death in the mammalian olfactory epithelium. Ciba Found Symp. 1996;196:188–205. discussion; −10.

    CAS  PubMed  Google Scholar 

  69. Nakashima T, Kimmelman CP, Snow Jr JB. Immunohistopathology of human olfactory epithelium, nerve and bulb. Laryngoscope. 1985;95(4):391–6.

    Article  CAS  PubMed  Google Scholar 

  70. Rombaux P, Mouraux A, Bertrand B, Nicolas G, Duprez T, Hummel T. Olfactory function and olfactory bulb volume in patients with postinfectious olfactory loss. Laryngoscope. 2006;116(3):436–9.

    Article  PubMed  Google Scholar 

  71. Rombaux P, Mouraux A, Bertrand B, Nicolas G, Duprez T, Hummel T. Retronasal and orthonasal olfactory function in relation to olfactory bulb volume in patients with posttraumatic loss of smell. Laryngoscope. 2006;116(6):901–5.

    Article  PubMed  Google Scholar 

  72. Huart C, Eloy P, Collet S, Rombaux P. Chemosensory function assessed with psychophysical testing and event-related potentials in patients with atrophic rhinitis. Eur Arch Otorhinolaryngol: Off J Eur Fed Otorhinolaryngol Soc. 2012;269(1):135–41.

    Article  CAS  Google Scholar 

  73. Dietz de Loos DA, Hopkins C, Fokkens WJ. Symptoms in chronic rhinosinusitis with and without nasal polyps. Laryngoscope. 2013;123(1):57–63.

    Article  PubMed  Google Scholar 

  74. Bramerson A, Johansson L, Ek L, Nordin S, Bende M. Prevalence of olfactory dysfunction: the Skovde population-based study. Laryngoscope. 2004;114(4):733–7.

    Article  PubMed  Google Scholar 

  75. Hox V, Bobic S, Callebaux I, Jorissen M, Hellings PW. Nasal obstruction and smell impairment in nasal polyp disease: correlation between objective and subjective parameters. Rhinology. 2010;48(4):426–32.

    CAS  PubMed  Google Scholar 

  76. Joe SA, Thakkar K. Chronic rhinosinusitis and asthma. Otolaryngol Clin N Am. 2008;41(2):297–309. vi.

    Article  Google Scholar 

  77. Dunlop G, Scadding GK, Lund VJ. The effect of endoscopic sinus surgery on asthma: management of patients with chronic rhinosinusitis, nasal polyposis, and asthma. Am J Rhinol. 1999;13(4):261–5.

    Article  CAS  PubMed  Google Scholar 

  78. Perry BF, Kountakis SE. Subjective improvement of olfactory function after endoscopic sinus surgery for chronic rhinosinusitis. Am J Otolaryngol. 2003;24(6):366–9.

    Article  PubMed  Google Scholar 

  79. Landis BN, Giger R, Ricchetti A, Leuchter I, Hugentobler M, Hummel T, et al. Retronasal olfactory function in nasal polyposis. Laryngoscope. 2003;113(11):1993–7.

    Article  PubMed  Google Scholar 

  80. Pfaar O, Landis BN, Frasnelli J, Huttenbrink KB, Hummel T. Mechanical obstruction of the olfactory cleft reveals differences between orthonasal and retronasal olfactory functions. Chem Senses. 2006;31(1):27–31.

    Article  PubMed  Google Scholar 

  81. Konstantinidis I, Triaridis S, Printza A, Vital V, Ferekidis E, Constantinidis J. Olfactory dysfunction in nasal polyposis: correlation with computed tomography findings. ORL J Otorhinolaryngol Relat Spec. 2007;69(4):226–32.

    Article  PubMed  Google Scholar 

  82. Blomqvist EH, Lundblad L, Bergstedt H, Stjarne P. Placebo-controlled, randomized, double-blind study evaluating the efficacy of fluticasone propionate nasal spray for the treatment of patients with hyposmia/anosmia. Acta Otolaryngol. 2003;123(7):862–8.

    Article  CAS  PubMed  Google Scholar 

  83. Lund VJ, MacKay IS. Outcome assessment of endoscopic sinus surgery. J R Soc Med. 1994;87(2):70–2.

    CAS  PubMed  PubMed Central  Google Scholar 

  84. Levine HL. Functional endoscopic sinus surgery: evaluation, surgery, and follow-up of 250 patients. Laryngoscope. 1990;100(1):79–84.

    Article  CAS  PubMed  Google Scholar 

  85. Miwa T, Furukawa M, Tsukatani T, Costanzo RM, DiNardo LJ, Reiter ER. Impact of olfactory impairment on quality of life and disability. Arch Otolaryngol Head Neck Surg. 2001;127(5):497–503.

    Article  CAS  PubMed  Google Scholar 

  86. Heilmann S, Huettenbrink KB, Hummel T. Local and systemic administration of corticosteroids in the treatment of olfactory loss. Am J Rhinol. 2004;18(1):29–33.

    PubMed  Google Scholar 

  87. Bonfils P, Halimi P, Malinvaud D. Adrenal suppression and osteoporosis after treatment of nasal polyposis. Acta Otolaryngol. 2006;126(11):1195–200.

    Article  CAS  PubMed  Google Scholar 

  88. Jakobsen J, Svendstrup F. Functional endoscopic sinus surgery in chronic sinusitis—a series of 237 consecutively operated patients. Acta Otolaryngol Suppl. 2000;543:158–61.

    Article  CAS  PubMed  Google Scholar 

  89. Klossek JM, Peloquin L, Friedman WH, Ferrier JC, Fontanel JP. Diffuse nasal polyposis: postoperative long-term results after endoscopic sinus surgery and frontal irrigation. Otolaryngol Head Neck Surg: Off J Am Acad Otolaryngol Head Neck Surg. 1997;117(4):355–61.

    Article  CAS  Google Scholar 

  90. Park AH, Lau J, Stankiewicz J, Chow J. The role of functional endoscopic sinus surgery in asthmatic patients. J Otolaryngol. 1998;27(5):275–80.

    CAS  PubMed  Google Scholar 

  91. Lund VJ, Scadding GK. Objective assessment of endoscopic sinus surgery in the management of chronic rhinosinusitis: an update. J Laryngol Otol. 1994;108(9):749–53.

    Article  CAS  PubMed  Google Scholar 

  92. Rudmik L, Smith TL. Olfactory improvement after endoscopic sinus surgery. Curr Opin Otolaryngol Head Neck Surg. 2012;20(1):29–32.

    Article  PubMed  PubMed Central  Google Scholar 

  93. Bonfils P, Malinvaud D, Soudry Y, Devars du Maine M, Laccourreye O. Surgical therapy and olfactory function. B-ENT. 2009;5 Suppl 13:77–87.

    PubMed  Google Scholar 

  94. Soler ZM, Sauer DA, Mace JC, Smith TL. Ethmoid histopathology does not predict olfactory outcomes after endoscopic sinus surgery. Am J Rhinol Allergy. 2010;24(4):281–5.

    Article  PubMed  PubMed Central  Google Scholar 

  95. Wright ED, Agrawal S. Impact of perioperative systemic steroids on surgical outcomes in patients with chronic rhinosinusitis with polyposis: evaluation with the novel Perioperative Sinus Endoscopy (POSE) scoring system. Laryngoscope. 2007;117(11 Pt 2 Suppl 115):1–28.

    Article  CAS  PubMed  Google Scholar 

  96. Jiang RS, Su MC, Liang KL, Shiao JY, Hsin CH, Lu FJ, et al. Preoperative prognostic factors for olfactory change after functional endoscopic sinus surgery. Am J Rhinol Allergy. 2009;23(1):64–70.

    Article  CAS  PubMed  Google Scholar 

  97. Bhattacharyya N. Radiographic stage fails to predict symptom outcomes after endoscopic sinus surgery for chronic rhinosinusitis. Laryngoscope. 2006;116(1):18–22.

    Article  PubMed  Google Scholar 

  98. Jankowski R, Bodino C. Olfaction in patients with nasal polyposis: effects of systemic steroids and radical ethmoidectomy with middle turbinate resection (nasalization). Rhinology. 2003;41(4):220–30.

    CAS  PubMed  Google Scholar 

  99. Jankowski R, Pigret D, Decroocq F. Comparison of functional results after ethmoidectomy and nasalization for diffuse and severe nasal polyposis. Acta Otolaryngol. 1997;117(4):601–8.

    Article  CAS  PubMed  Google Scholar 

  100. Konstantinidis I, Tsakiropoulou E, Bekiaridou P, Kazantzidou C, Constantinidis J. Use of olfactory training in post-traumatic and postinfectious olfactory dysfunction. Laryngoscope. 2013;123(12):E85–90.

    Article  PubMed  Google Scholar 

  101. Hummel T, Rissom K, Reden J, Hahner A, Weidenbecher M, Huttenbrink KB. Effects of olfactory training in patients with olfactory loss. Laryngoscope. 2009;119(3):496–9.

    Article  PubMed  Google Scholar 

  102. Damm M, Pikart LK, Reimann H, Burkert S, Goktas O, Haxel B, et al. Olfactory training is helpful in postinfectious olfactory loss: a randomized, controlled, multicenter study. Laryngoscope. 2014;124(4):826–31.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Otorhinolaryngology, Cliniques Universitaires Saint Luc, Université Catholique de Louvain, Av Hippocrate, 10, 1200, Brussels, Belgium

    Philippe Rombaux & C. Huart

  2. Institute of Neurosciences, Université Catholique de Louvain, Brussels, Belgium

    Philippe Rombaux & C. Huart

  3. Department of Otorhinolaryngology, Clinique Sainte-Anne, Brussels, Belgium

    P. Levie

  4. ENT Department, Medical Faculty, Eskisehir Osmangazi University, Eskisehir, Turkey

    C. Cingi

  5. Interdisciplinary Center “Smell & Taste”, Department of Otorhinolaryngology, TU Dresden, Dresden, Germany

    T. Hummel

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  1. Philippe Rombaux
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Correspondence to Philippe Rombaux.

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Rombaux, P., Huart, C., Levie, P. et al. Olfaction in Chronic Rhinosinusitis. Curr Allergy Asthma Rep 16, 41 (2016). https://doi.org/10.1007/s11882-016-0617-6

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