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Comparison between oxidative potentials measured of water-soluble components in ambient air PM1 and PM2.5 of Tehran, Iran

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Abstract

Epidemiological studies suggest that measuring the oxidation potential of particles is more appropriate than measuring PM mass concentration. For the quantification of oxidation potential (OP) associated with ambient particulate matter (PM), two cell-based and cell-free methods are commonly used. One of the most widely used cell-free methods for particle oxidation potential is the dithiothreitol (DTT, HSCH2 (CH (OH))2 CH2SH)), which requires less controlled environments and offers faster readout of PM oxidative potential. In the present study, to observe the seasonal variations of the OP of the particulate matter of different sizes (PM1, PM2.5), using a DTT assay water-based, the OP was measured during spring, summer, and autumn in the ambient air of Tehran city, the capital of Iran from 2021/4/17 to 2021/12/6. PM1 samples were collected with Sioutas cascade impactor using low-volume air samplers operating at a flow rate of 9 L/min, with high-volume air samplers (operating at a flow rate of 1.415 m3/min) used for PM2.5. PM1 and PM2.5 mass concentrations in ambient air were within (13.8–111.2) and (18.4–148.2) μg/m3 respectively. The results of the present study revealed that generally, OP of PM1 was higher than OP of PM2.5, and this value was larger in autumn than in spring and in spring higher than in summer. The correlation between the mass concentration of PM2.5 and oxidative potential mass normalized (OPDTTm) for total and spring was significant with R2 equal to 0.64 and 0.81, respectively, while a significant correlation was observed between oxidative potential volume normalized (OPDTTv) and PM2.5 mass concentration in summer with R2 of 0.63. It is expected that the existence of these studies can lead to measuring oxidative potential with the direct reading approach in the future.

Highlights

• The ability of particles to generate reactive oxygen species (ROS) was measured for the first time in Iran.

• Acellular assay dithiothreitol was used for oxidative potential (OP) in ambient air PM1 and PM2.5 of Tehran, Iran.

• OP of PM1 was higher than the OP of PM2.5

• The value OP of PM1 and PM2.5 was higher in autumn > spring > summer.

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Data availability

The datasets used or analyzed during the current study are available from the corresponding author upon reasonable request.

Abbreviations

WHO:

World Health Organization

EPA:

Environmental Protection Agency

PM:

Particulate matter

PM2.5 :

PM ≤ 2.5 μm in diameter

PM1 :

PM ≤ 1 μm in diameter

OP:

Oxidative Potential

ROS:

Reactive Oxygen Species

DTT:

Dithiothreitol

PB:

Phosphate Buffer

DTNB:

5,5-Dithio-bis-2-nitrobenzoic acid

ANOVA:

One-way analysis of variance

SD:

Standard deviation

AA:

Ascorbate assay

GDH:

Reduced glutathione (assay)

ESR:

Electron spin resonance

C:

Concentration

TCA:

Trichloroacetic acid

OPDTTm :

Oxidative potential mass normalized

OPDTTv :

Oxidative potential mass normalized

References

  • Abbasi S, Keshavarzi B, Moore F, Hopke PK, Kelly FJ, Dominguez AO (2020) Elemental and magnetic analyses, source identification, and oxidative potential of airborne, passive, and street dust particles in Asaluyeh County, Iran. Sci Total Environ 707:136132–136200

    Article  CAS  Google Scholar 

  • Agency EP (1998) SLAMS/NAMS/PAMS network review guidance. Report No: EPA-454/R 98–003, U.S. Environmental Protection Agency. EPA-454/R-98-003

  • Agency USEp (2019) US Environmental Protection Agency National Contingency Plan (NCP) Product Schedule February 2019. from https://nepis.epa.gov/Exe/ZyPURL.cgi?Dockey=P100WANW.txt

  • Ahmad M, Yu Q, Chen J, Cheng S, Qin W, Zhang Y (2021) Chemical characteristics, oxidative potential, and sources of PM(2.5) in wintertime in Lahore and Peshawar, Pakistan. J Environ Sci (China) 102:148–158

    Article  CAS  Google Scholar 

  • Arhami M, Hosseini V, Shahne MZ, Bigdeli M, Lai A, Schauer JJ (2017) Seasonal trends, chemical speciation and source apportionment of fine PM in Tehran. Atmos Environ 153:70–82

    Article  CAS  Google Scholar 

  • Arhami M, Kamali N, Rajabi MM (2013) Predicting hourly air pollutant levels using artificial neural networks coupled with uncertainty analysis by Monte Carlo simulations. Environ Sci Pollut Res 20(7):4777–4789

    Article  CAS  Google Scholar 

  • Arias S, Molina F, Agudelo JR (2021) Palm oil biodiesel: an assessment of PAH emissions, oxidative potential and ecotoxicity of particulate matter. J Environ Sci 101:326–338

    Article  CAS  Google Scholar 

  • Ashrafi K, Fallah R, Hadei M, Yarahmadi M, Shahsavani A (2018) Source apportionment of total suspended particles (TSP) by positive matrix factorization (PMF) and chemical mass balance (CMB) modeling in Ahvaz, Iran. Arch Environ Contam Toxicol 75(2):278–294

    Article  CAS  Google Scholar 

  • Asl FB, Leili M, Vaziri Y, Arian SS, Cristaldi A, Conti GO, Ferrante M (2018) Health impacts quantification of ambient air pollutants using AirQ model approach in Hamadan, Iran. Environ Res 161:114–121

    Article  Google Scholar 

  • Bell ML, Dominici F, Ebisu K, Zeger SL, Samet JM (2007) Spatial and temporal variation in PM2. 5 chemical composition in the United States for health effects studies. Environ Health Perspect 115(7):989–995

    Article  CAS  Google Scholar 

  • Bowe B, Xie Y, Li T, Yan Y, Xian H, Al-Aly Z (2019) Estimates of the 2016 global burden of kidney disease attributable to ambient fine particulate matter air pollution. BMJ Open 9(5):22450–22458

    Article  Google Scholar 

  • Breznan D, Nazemof N, Kunc F, Hill M, Vladisavljevic D, Gomes J, Johnston LJ, Vincent R, Kumarathasan P (2020) Acellular oxidative potential assay for screening of amorphous silica nanoparticles. Analyst 145(14):4867–4879

    Article  CAS  Google Scholar 

  • Cachon FB, Cazier F, Verdin A, Dewaele D, Genevray P, Delbende A, Ayi-Fanou L, Aïssi F, Sanni A, Courcot D (2023) Physicochemical characterization of air pollution particulate matter (PM2. 5 and PM> 2.5) in an urban area of Cotonou, Benin. Atmosphere 14(2):201–212

    Article  CAS  Google Scholar 

  • Cesaroni G, Boogaard H, Jonkers S, Porta D, Badaloni C, Cattani G, Forastiere F, Hoek G (2012) Health benefits of traffic-related air pollution reduction in different socioeconomic groups: the effect of low-emission zoning in Rome. Occup Environ Med 69(2):133–139

    Article  CAS  Google Scholar 

  • Chandra I, Nisa K, Rosdiana E (2021) Preliminary study: health risk analysis of PM2. 5 and PM10 mass concentrations in Bandung Metropolitan. IOP Conference Series: Earth and Environmental Science, IOP Publishing

  • Charrier JG, Anastasio C (2012) On dithiothreitol (DTT) as a measure of oxidative potential for ambient particles: evidence for the importance of soluble transition metals. Atmos Chem Phys 12(5):11317–11350

    CAS  Google Scholar 

  • Cheng Y, Ma Y, Dong B, Qiu X, Hu D (2021) Pollutants from primary sources dominate the oxidative potential of water-soluble PM2 5 in Hong Kong in terms of dithiothreitol (DTT) consumption and hydroxyl radical production. J Hazard Mater 405:124218–124230

    Article  CAS  Google Scholar 

  • Cho AK, Sioutas C, Miguel AH, Kumagai Y, Schmitz DA, Singh M, Eiguren-Fernandez A, Froines JR (2005) Redox activity of airborne particulate matter at different sites in the Los Angeles Basin. Environ Res 99(1):40–47

    Article  CAS  Google Scholar 

  • Faridi S, Shamsipour M, Krzyzanowski M, Künzli N, Amini H, Azimi F, Malkawi M, Momeniha F, Gholampour A, Hassanvand MS (2018) Long-term trends and health impact of PM2. 5 and O3 in Tehran, Iran, 2006–2015. Environ Int 114:37–49

    Article  CAS  Google Scholar 

  • Gao D, Mulholland JA, Russell AG, Weber RJ (2020) Characterization of water-insoluble oxidative potential of PM2 5 using the dithiothreitol assay. Atmosp Environ 224:117327

    Article  CAS  Google Scholar 

  • Gao D, Ripley S, Weichenthal S, Godri Pollitt KJ (2020b) Ambient particulate matter oxidative potential: chemical determinants, associated health effects, and strategies for risk management. Free Radic Biol Med 151:7–25

    Article  CAS  Google Scholar 

  • Ghasemzadeh B, Sharifi A (2020) Modeling and analysis of barriers to climate change adaptation in Tehran. Climate 8(10):104–118

    Article  Google Scholar 

  • Grahame TJ, Schlesinger RB (2007) Health effects of airborne particulate matter: do we know enough to consider regulating specific particle types or sources? Inhalation Toxicol 19(6–7):457–481

    Article  CAS  Google Scholar 

  • Hassanvand MS, Naddafi K, Faridi S, Arhami M, Nabizadeh R, Sowlat MH, Pourpak Z, Rastkari N, Momeniha F, Kashani H (2014) Indoor/outdoor relationships of PM10, PM2. 5, and PM1 mass concentrations and their water-soluble ions in a retirement home and a school dormitory. Atmos Environ 82:375–382

    Article  CAS  Google Scholar 

  • Hayes JD, Dinkova-Kostova AT, Tew KD (2020) Oxidative stress in cancer. Cancer Cell 38(2):167–197

  • Jedynska A, Hoek G, Wang M, Yang A, Eeftens M, Cyrys J, Keuken M, Ampe C, Beelen R, Cesaroni G (2017) Spatial variations and development of land use regression models of oxidative potential in ten European study areas. Atmos Environ 150:24–32

    Article  CAS  Google Scholar 

  • Kermani M, Jafari A, Gholami M, Arfaeinia H, Shahsavani A, Norouzian A, Dowlati M (2020) Investigation of relationship between particulate matter (PM2. 5) and meteorological parameters in Isfahan, Iran. J Air Pollut Health 5(2):97–106

    Google Scholar 

  • Khoshkam Z, Habibi-Rezaei M, Hassanvand MS, Aftabi Y, Seyedrezazadeh E, Amiri-Sadeghan A, Zarredar H, Roshangar L, Gholampour A, Moosavi-Movahedi A (2021) The oxidative and neurotoxic potentials of the ambient PM2.5 extracts: the efficient multi-solvent extraction method. Sci Total Environ 810:152291–152308

  • Khoshnamvand N, Azizi N, Naddafi K, Hassanvand MS (2022) The effect of size distribution of ambient air particulate matter on oxidative potential by acellular method dithiothreitol; a systematic review. J Environ Health Sci Eng 20(1):579–588

  • Li Z, Nie D, Chen M, Ge P, Liu Z, Ma X, Ge X, Gu R (2021) Seasonal variation of oxidative potential of water-soluble components in PM2. 5 and PM1 in the Yangtze River Delta, China. Air Qual Atmos Health:1–12

  • Liu Q, Baumgartner J, Zhang Y, Liu Y, Sun Y, Zhang M (2014) Oxidative potential and inflammatory impacts of source apportioned ambient air pollution in Beijing. Environ Sci Technol 48(21):12920–12929

    Article  CAS  Google Scholar 

  • Ma X, Nie D, Chen M, Ge P, Liu Z, Ge X, Li Z, Gu R (2021) The relative contributions of different chemical components to the oxidative potential of ambient fine particles in Nanjing area. Int J Environ Res Public Health 18(6):2789–2806

    Article  CAS  Google Scholar 

  • Møller P, Danielsen PH, Karottki DG, Jantzen K, Roursgaard M, Klingberg H, Jensen DM, Christophersen DV, Hemmingsen JG, Cao Y, Loft S (2014) Oxidative stress and inflammation generated DNA damage by exposure to air pollution particles. Mutat Res Rev Mutat Res 762:133–166

    Article  Google Scholar 

  • Perrone MR, Bertoli I, Romano S, Russo M, Rispoli G, Pietrogrande MC (2019) PM2. 5 and PM10 oxidative potential at a central Mediterranean site: contrasts between dithiothreitol-and ascorbic acid-measured values in relation with particle size and chemical composition. Atmos Environ 210:143–155

    Article  CAS  Google Scholar 

  • Puthussery JV, Singh A, Rai P, Bhattu D, Kumar V, Vats P, Furger M, Rastogi N, Slowik JG, Ganguly D (2020) Real-time measurements of PM2. 5 oxidative potential using a dithiothreitol assay in Delhi, India. Environ Sci Technol Lett 7(7):504–510

    Article  CAS  Google Scholar 

  • Rezaei S, Naddafi K, Hassanvand MS, Nabizadeh R, Yunesian M, Ghanbarian M, Atafar Z, Faraji M, Nazmara S, Mahmoudi B (2018) Physiochemical characteristics and oxidative potential of ambient air particulate matter (PM 10) during dust and non-dust storm events: a case study in Tehran, Iran. J Environ Health Sci Eng 16(2):147–158

    Article  CAS  Google Scholar 

  • Shafer MM, Hemming JD, Antkiewicz DS, Schauer JJ (2016) Oxidative potential of size-fractionated atmospheric aerosol in urban and rural sites across Europe. Faraday Discuss 189:381–405

    Article  CAS  Google Scholar 

  • Shahadin MS, Mutalib NSA, Latif MT, Greene CM, Hassan T (2018) Challenges and future direction of molecular research in air pollution-related lung cancers. Lung Cancer 118:69–75

    Article  Google Scholar 

  • Verma V, Fang T, Guo H, King L, Bates J, Peltier R, Edgerton E, Russell A, Weber R (2014) Reactive oxygen species associated with water-soluble PM 2.5 in the southeastern United States: spatiotemporal trends and source apportionment. Atmos Chem Phys 14(23):12915–12930

    Article  Google Scholar 

  • Verma V, Fang T, Xu L, Peltier RE, Russell AG, Ng NL, Weber RJ (2015) Organic aerosols associated with the generation of reactive oxygen species (ROS) by water-soluble PM2.5. Environ Sci Technol 49(7):4646–4656

    Article  CAS  Google Scholar 

  • Verma V, Pakbin P, Cheung KL, Cho AK, Schauer JJ, Shafer MM, Kleinman MT, Sioutas C (2011) Physicochemical and oxidative characteristics of semi-volatile components of quasi-ultrafine particles in an urban atmosphere. Atmos Environ 45(4):1025–1033

    Article  CAS  Google Scholar 

  • Vreeland H, Weber R, Bergin M, Greenwald R, Golan R, Russell AG, Verma V, Sarnat JA (2017) Oxidative potential of PM2. 5 during Atlanta rush hour: measurements of in-vehicle dithiothreitol (DTT) activity. Atmos Environ 165:169–178

    Article  CAS  Google Scholar 

  • Wang Y, Wang M, Li S, Sun H, Mu Z, Zhang L, Li Y, Chen Q (2020) Study on the oxidation potential of the water-soluble components of ambient PM2. 5 over Xi’an, China: pollution levels, source apportionment and transport pathways. Environ Int 136:105515–105526

    Article  CAS  Google Scholar 

  • Wang Y, Xiao S, Zhang Y, Chang H, Martin RV, Van Donkelaar A, Gaskins A, Liu Y, Liu P, Shi L (2022) Long-term exposure to PM2. 5 major components and mortality in the southeastern United States. Environ Int 158:106969–106978

    Article  CAS  Google Scholar 

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Acknowledgements

The authors would thank the Center for Air Pollution Research (CAPR), Institute for Environmental Research (IER), and Tehran University of Medical Sciences.

Funding

This study was funded by the Tehran University of Medical Sciences (grant number: 50803) and the Iran National Science Foundation (INSF) (grant number: 99029028).

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Authors and Affiliations

  1. Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

    Nahid Khoshnamvand, Ramin Nabizadeh Nodehi, Mohammad Sadegh Hassanvand & Kazem Naddafi

  2. Center for Air Pollution Research (CAPR), Institute for Environmental Research (IER), Tehran University of Medical Sciences, Tehran, Iran

    Mohammad Sadegh Hassanvand & Kazem Naddafi

Authors
  1. Nahid Khoshnamvand
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  2. Ramin Nabizadeh Nodehi
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  3. Mohammad Sadegh Hassanvand
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  4. Kazem Naddafi
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Contributions

Nahid Khoshanamvand: data curation, methodology, validation, formal analysis, investigation, writing—original draft, visualization. Ramin Nabizadeh Nodehi: methodology, validation, review and editing. Mohammad Sadegh Hassanvand: review and editing, methodology. Kazem Nadafi: supervision, conceptualization, resources, review, and editing, project administration, funding acquisition.

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Correspondence to Kazem Naddafi.

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Khoshnamvand, N., Nodehi, R.N., Hassanvand, M.S. et al. Comparison between oxidative potentials measured of water-soluble components in ambient air PM1 and PM2.5 of Tehran, Iran. Air Qual Atmos Health 16, 1311–1320 (2023). https://doi.org/10.1007/s11869-023-01343-y

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