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A prospective feasibility study of MammoSite accelerated partial breast irradiation for early breast Cancer

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Irish Journal of Medical Science (1971 -) Aims and scope Submit manuscript

Abstract

Background

Accelerated partial breast irradiation is a potential alternative to standard whole breast irradiation, following breast-conserving surgery, in the management of breast cancer. The MammoSite applicator–based technique allows for the delivery of a higher dose of radiation to the tumour bed and adjacent area, over a shorter treatment period.

Aims

To investigate the long-term feasibility of the MammoSite technique in early stage breast cancer in an Irish cohort.

Methods

Sixty-two patients with early stage breast cancer were enrolled in this prospective study between November 2005 and October 2012 at the University Hospital Galway. A single-entry MammoSite applicator was inserted post-operatively. A CT scan was performed to assess the balloon to skin distance, the conformance of target tissue to balloon surface and balloon symmetry. A total dose of 34 Gy was delivered over 10 fractions twice daily.

Results

Median follow-up was 10 years. 91.9% (57/62) completed the full course of MammoSite treatment. Technical issues with the MammoSite balloon precluded three patients from completing the full course of treatment. On last follow-up, 6.4% (4/62) of patients had developed an ipsilateral breast recurrence. Half of these recurrences occurred more than 10 years after the initial breast cancer treatment. The most common toxicities observed were fibrosis (67.7%), pain (61.3%) and skin erythema (35.5%).

Conclusion

The use of the MammoSite technique, as an alternative to standard whole breast irradiation, is feasible in a typical Irish clinical setting with integrated multidisciplinary team input.

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Authors and Affiliations

  1. Department of Radiation Oncology, University Hospital Galway, Galway, Ireland

    Rebecca L. Geary, Taleen Haddad, Aisling Barry, Anysja Zuchora, Ray McLaughlin, Michael Kerin, Francis J Sullivan & Joseph Martin

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  1. Rebecca L. Geary
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  2. Taleen Haddad
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Correspondence to Rebecca L. Geary.

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Approval was granted by the local research ethics board.

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Geary, R.L., Haddad, T., Barry, A. et al. A prospective feasibility study of MammoSite accelerated partial breast irradiation for early breast Cancer. Ir J Med Sci 189, 1203–1208 (2020). https://doi.org/10.1007/s11845-020-02237-z

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  • DOI: https://doi.org/10.1007/s11845-020-02237-z

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