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Automated quantification of foveal avascular zone and vascular density in Behçet’s disease

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Abstract

Purpose

To measure the vascular density (VD) and foveal avascular zone (FAZ) area in patients with Behçet’s disease (BD) obtained by optical coherence tomography angiography (OCTA).

Methods

VD and FAZ area in the deep and superficial retinal vascular networks were measured in all eyes.

Results

Thirty BD and 31 control subjects were included in the study. The mean overall VD measured in the entire scan was lower in BD compared with control group in both the superficial (49.52 ± 6.54 vs 53.57 ± 2.87%, respectively; p = 0.003) and deep (53.44 ± 7.44 vs 58.41 ± 3.01%, respectively; p = 0.002) areas. The FAZ in the BD group was significantly increased at the level of the superficial (0.52 ± 0.67 vs 0.28 ± 0.1 mm2, respectively; p = 0.05) and deep (0.91 ± 1.25 vs 0.39 ± 0.14 mm2, respectively; p = 0.024) areas compared with those of the control group. The deep and the superficial FAZ areas were positively correlated with disease duration and negatively with VA.

Conclusion

In the patients with BD, OCTA showed decreased VD in both the superficial and deep retinal vascular networks. Besides, the VA was correlated with the VD and FAZ.

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Funding

This study was financially supported by the Scientific Research Fund of Dicle University (TIP.15.041).

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Bower Private Hospital, Diyarbakir, Turkey

    Fatih Mehmet Türkcü

  2. Department of Ophthalmology, Batman Zilan Hospital, Batman, Turkey

    Alparslan Şahin

  3. Department of Ophthalmology, Batman State Hospital, Batman, Turkey

    Ümit Karaalp

  4. School of Medicine, Department of Ophthalmology, Dicle University, Diyarbakir, Turkey

    Yasin Çınar, Muhammed Şahin, Zeynep Gürsel Özkurt & Uğur Keklikçi

Authors
  1. Fatih Mehmet Türkcü
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  2. Alparslan Şahin
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  3. Ümit Karaalp
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  4. Yasin Çınar
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  5. Muhammed Şahin
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  6. Zeynep Gürsel Özkurt
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  7. Uğur Keklikçi
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Corresponding author

Correspondence to Muhammed Şahin.

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This research was carried out with the approval of the ethics committee of the institution involved.

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The authors declare that they have no conflicts of interest.

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Türkcü, F.M., Şahin, A., Karaalp, Ü. et al. Automated quantification of foveal avascular zone and vascular density in Behçet’s disease. Ir J Med Sci 189, 349–354 (2020). https://doi.org/10.1007/s11845-019-02051-2

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  • DOI: https://doi.org/10.1007/s11845-019-02051-2

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