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Prevalence and predictors of human papillomavirus (HPV) vaccination among young women surviving childhood cancer

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Abstract

Purpose

Human papillomavirus (HPV) is a sexually transmitted infection and the cause of cervical and other cancers. Vaccination is available to protect against genital HPV and is recommended for individuals aged 9–26 years. This study aimed to estimate the prevalence of HPV vaccination among childhood cancer survivors and to identify factors associated with vaccine outcomes.

Methods

Young adult females with (n = 114; M age = 21.18 years, SD = 2.48) and without (n = 98; M age = 20.65 years, SD = 2.29) a childhood cancer history completed surveys querying HPV vaccination initiation/completion, as well as sociodemographic, medical, and health belief factors. Multivariable logistic regression was used to calculate odds ratios (ORs) and 95 % confidence intervals (CIs) for vaccine outcomes.

Results

Among survivors, 38.6 % (44/114) and 26.3 % (30/114) initiated or completed vaccination compared to 44.9 % (44/98) and 28.6 % (28/98) among controls, respectively. In the combined survivor/control group, physician recommendation (OR = 11.24, 95 % CI 3.15–40.14) and familial HPV communication (OR = 7.28, 95 % CI 1.89–28.05) associated with vaccine initiation. Perceptions of vaccine benefit associated with vaccine completion (OR = 10.55, 95 % CI 1.59–69.92), whereas perceptions of HPV-related severity associated with non-completion (OR = 0.14, 95 % CI 0.03–0.71).

Conclusion

Despite their increased risk for HPV-related complication, a minority of childhood cancer survivors have initiated or completed HPV vaccination. Modifiable factors associated with vaccine outcomes were identified.

Implications for Cancer Survivors

HPV vaccination is a useful tool for cancer prevention in survivorship, and interventions to increase vaccine uptake are warranted.

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Author information

Authors and Affiliations

  1. Department of Psychology, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105-2794, USA

    James L. Klosky, Kelly R. Peck, Jessica L. Simmons & Kathryn M. Russell

  2. Department of Psychology, Winona State University, 175 W Mark St, Winona, MN, 55987, USA

    Brianne Favaro

  3. Department of Oncology, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105-2794, USA

    Daniel M. Green & Melissa M. Hudson

  4. Department of Epidemiology & Cancer Control, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105-2794, USA

    Daniel M. Green & Melissa M. Hudson

  5. Department of Psychology, University of Mississippi, 205 Peabody, University, MS, 38677, USA

    Kelly R. Peck

Authors
  1. James L. Klosky
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  2. Brianne Favaro
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  4. Jessica L. Simmons
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Corresponding author

Correspondence to James L. Klosky.

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The authors declare that they have no competing interests.

Additional information

This work was supported in part by the Cancer Center Support (CORE) (grant number CA21765) and the American Lebanese Syrian Associated Charities (ALSAC).

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Klosky, J.L., Favaro, B., Peck, K.R. et al. Prevalence and predictors of human papillomavirus (HPV) vaccination among young women surviving childhood cancer. J Cancer Surviv 10, 449–456 (2016). https://doi.org/10.1007/s11764-015-0495-2

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  • DOI: https://doi.org/10.1007/s11764-015-0495-2

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