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A series of experiences with TissuePatch™ for alveolar air leak after pulmonary resection

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Abstract

Objectives

Prolonged air leak after pulmonary resection strongly influences chest tube duration and hospitalization. This prospective study aimed to report a series of experiences with a synthetic sealant (TissuePatch™) and compare them with a combination covering method (polyglycolic acid sheet + fibrin glue) for air leaks after pulmonary surgery.

Methods

We included 51 patients (age: 20–89 years) who underwent lung resection. Patients who presented with alveolar air leak during the intraoperative water sealing test were randomly assigned to the TissuePatch™ or combination covering method groups. The chest tube was removed when there was no air leak over a period of 6 h, and no active bleeding under continuous monitoring using a digital drainage system. The chest tube duration was assessed, and various perioperative factors (such as the index of prolonged air leak score) were evaluated.

Results

Twenty (39.2%) patients developed intraoperative air leak; ten patients received TissuePatch™; and one patient who was receiving TissuePatch™ switched to the combination covering method because of broken TissuePatch™. The chest tube duration, index of prolonged air leak score, prolonged air leak, other complications, and postoperative hospitalization in both groups were similar. No TissuePatch™-related adverse events were reported.

Conclusions

Results from the use of TissuePatch™ were almost similar to those associated with the use of combination covering method in preventing prolonged postoperative air leak after pulmonary resection. Randomized, double-arm studies are required to confirm the efficacy of TissuePatch™ observed during this study.

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Data availability

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request after approval from the Ethical Committee of Toyama University Hospital. The period ends 3 months to 3 years after publication.

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Acknowledgements

We would like to thank Editage (www.editage.com) for the English language editing.

Funding

This study was funded by the Toyama Prefecture Citizens’ Personal Development Foundation (TomiHito #52).

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Authors and Affiliations

  1. Division of Thoracic Surgery, Kurobe City Hospital, 1108-1 Mikkaichi, Kurobe, Toyama, 938-8502, Japan

    Takahiro Homma

  2. Division of Thoracic Surgery, University of Toyama, Toyama, Japan

    Takahiro Homma

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  1. Takahiro Homma
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Contributions

Conception and design, administrative support, provision of study materials or access to patients, collection and assembly of data, data analysis and interpretation, manuscript writing, and final approval of the manuscript: TH.

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Correspondence to Takahiro Homma.

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Homma, T. A series of experiences with TissuePatch™ for alveolar air leak after pulmonary resection. Gen Thorac Cardiovasc Surg 71, 570–576 (2023). https://doi.org/10.1007/s11748-023-01921-y

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  • DOI: https://doi.org/10.1007/s11748-023-01921-y

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