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Clinical management of coagulation status and placenta previa in a pregnant woman with Marfan’s syndrome after mitral and aortic mechanical heart valve replacement

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Abstract

Pregnancy with a mechanical heart valve (MHV) is high risk for valve thrombosis because pregnancy is a hyper-coagulation state. In addition, warfarin use during pregnancy is restricted due to its fetotoxicity, and postpartum bleeding may be increased with anticoagulation. In particular, placenta previa under anticoagulation may cause massive postpartum bleeding. The optimal anticoagulation for a pregnant woman with mitral and aortic double MHVs is not known. In addition, suitable techniques for control of bleeding in a case of placenta previa under anticoagulation are not known. Thus, a case of a pregnant woman with mitral and aortic double MHVs and placenta previa is presented. The case was managed without valve thrombosis through precise unfractionated heparin dose adjustment and frequent activated partial thromboplastin time monitoring, along with maintenance of antithrombin levels. Compression sutures were found to be effective for controlling bleeding from the attachment site of placenta previa even under anticoagulation.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, National Cerebral and Cardiovascular Center, 6-1, Kishibeshinmachi, Suita City, Osaka Prefecture, Japan

    Atsushi Nakanishi, Chizuko A. Kamiya, Tadasu Shionoiri, Naoko Iwanaga & Jun Yoshimatsu

  2. Department of Cardiovascular Surgery, National Cerebral and Cardiovascular Center, 6-1, Kishibeshinmachi, Suita City, Osaka Prefecture, Japan

    Hiroaki Sasaki & Hitoshi Matsuda

Authors
  1. Atsushi Nakanishi
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  2. Chizuko A. Kamiya
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  3. Tadasu Shionoiri
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  4. Naoko Iwanaga
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  5. Hiroaki Sasaki
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  6. Hitoshi Matsuda
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  7. Jun Yoshimatsu
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Correspondence to Atsushi Nakanishi.

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The present article was described in accordance with the Helsinki Declaration of 1964. We also obtained informed consent from the patient.

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Nakanishi, A., Kamiya, C.A., Shionoiri, T. et al. Clinical management of coagulation status and placenta previa in a pregnant woman with Marfan’s syndrome after mitral and aortic mechanical heart valve replacement. Gen Thorac Cardiovasc Surg 69, 550–554 (2021). https://doi.org/10.1007/s11748-020-01494-0

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  • DOI: https://doi.org/10.1007/s11748-020-01494-0

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