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New Role of Hispidulin in Lipid Metabolism: PPARα Activator

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Lipids

Abstract

Hispidulin is a naturally occurring flavonoid isolated from a traditional Chinese medicinal herb, Saussurea involucrata. In this study, the regulating role of hispidulin on the mRNA expression level of enzymes involved in lipid metabolism was examined in vitro and in vivo. Moreover, the in vivo lipid-modulating effect of hispidulin was compared with that of fenofibrate, a classical PPARα agonist. Our results in present study demonstrated that hispidulin can directly bind to and activate PPARα as an agonist and thus modulate the downstream lipid-metabolizing genes. Moreover, hispidulin could attenuate dyslipidemia in high fat diet induced dyslipidemia rat model. Although further studies are needed, this study provided evidence for the potential use of hispidulin in dyslipidemia management.

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Abbreviations

PPARα:

Peroxisome proliferator-activated receptor alpha

NAFLD:

Nonalcoholic fatty liver disease

NASH:

Nonalcoholic steatohepatitis

FA:

Fatty-acid

LBD:

Ligand biding domain

Acsl 1:

Acyl-CoA synthetase 1

CPT1α:

Carnitine palmitoyltransferase 1α

Acat1:

Acetyl-CoA acetyltransferase 1

Acad1:

Acyl-coenzyme A dehydrogenase 1

HMGCS2:

HMG-CoA synthase 2

Acox1:

Acyl-CoA oxidase 1

Ech1:

Enoyl coenzyme a hydratase 1

EHHADH:

Enoyl-CoA, 3-hydroxyacyl CoA Dehydrogenase

Fasn:

Fatty acid synthase

Acaca:

Acetyl-CoA carboxylase 1

Elovl3:

Elongation of very long chain fatty acids 3

Lipe:

Hormone-sensitive lipase

Pnpla2:

Adipose triglyceride lipase

n-3 PUFAs:

N-3 polyunsaturated FA

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Authors and Affiliations

  1. Department of Endocrinology, The Affiliated Jiangyin People’s Hospital, School of Medicine, Southeast University, Jiangyin, 214400, China

    Xinchi Wu & Juan Xu

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  1. Xinchi Wu
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  2. Juan Xu
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Correspondence to Juan Xu.

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Wu, X., Xu, J. New Role of Hispidulin in Lipid Metabolism: PPARα Activator. Lipids 51, 1249–1257 (2016). https://doi.org/10.1007/s11745-016-4200-7

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  • DOI: https://doi.org/10.1007/s11745-016-4200-7

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