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Acupuncture intervening depressive disorder: research progress in its neurobiological mechanism

针刺干预抑郁症的神经生物学机制研究进展

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Abstract

Depressive disorder seriously affects people’s physical and mental health. Acupuncture is a safe and effective treatment for depression, yet, its mechanism is unclear. Therefore, acupuncture’s action mechanism in intervening depression was summarized from several perspectives, including morphology and ultrastructure of neurons in depression-related brain areas, function and structure of glial cells, brain functional and structural connectivity, and neuroelectrophysiology. It’s discovered that acupuncture can repair the morphological and ultrastructural damage of neurons in the hippocampus and prefrontal lobe, mitigate the functional and structural injuries of glial cells in the hippocampus and prefrontal lobe, strengthen functional connectivity and heal structural connection, and promote neuroelectrophysiological activities, which possibly are the principal mechanisms of how acupuncture works in intervening depressive disorder.

摘要

抑郁症严重影响身心健康, 针刺治疗抑郁症安全有效, 但其作用机制尚未完全明确。因此, 从抑郁相关脑区神经元形态及超微结构、神经胶质细胞功能和结构、大脑功能和结构连接、神经电生理方面总结针刺干预抑郁症的作用机制, 发现针刺可修复海马和前额叶神经元形态及超微结构损害, 改善海马和前额叶神经胶质细胞功能和结构损伤, 增强功能连接和修复结构连接, 促进神经电生理活动; 这些可能是针刺干预抑郁症的主要作用机制。

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Acknowledgments

This work was supported by Scientific Research and Innovation Funds Project of Gansu University of Traditional Chinese Medicine (甘肃中医药大学科学研究与创新基金 项目, No. 2021KCYB-1).

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Authors and Affiliations

  1. School of Acupuncture and Tuina, Gansu University of Traditional Chinese Medicine, Lanzhou, 730000, China

    Pengfei Li  (李芃菲), Min Xiao  (肖敏), Xuejiao Ma  (马雪娇), Xingke Yan  (严兴科) & Chongbing Ma  (马重兵)

Authors
  1. Pengfei Li  (李芃菲)
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  2. Min Xiao  (肖敏)
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  3. Xuejiao Ma  (马雪娇)
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  4. Xingke Yan  (严兴科)
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  5. Chongbing Ma  (马重兵)
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Corresponding authors

Correspondence to Xingke Yan  (严兴科) or Chongbing Ma  (马重兵).

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The authors declare that there is no potential conflict of interest in this article.

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Li, P., Xiao, M., Ma, X. et al. Acupuncture intervening depressive disorder: research progress in its neurobiological mechanism. J. Acupunct. Tuina. Sci. 21, 239–246 (2023). https://doi.org/10.1007/s11726-023-1381-5

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  • DOI: https://doi.org/10.1007/s11726-023-1381-5

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