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Observation of the efficacy and safety of the Song-Relaxing and Zhen-Vibrating abdomen manipulation for patients with prediabetes

松振腹法干预糖尿病前期患者的疗效及安全性观察

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Journal of Acupuncture and Tuina Science Aims and scope Submit manuscript

Abstract

Objective

To observe the safety of the Song-Relaxing and Zhen-Vibrating abdomen manipulation in treating patients with prediabetes and its effects on blood glucose and lipid metabolism.

Methods

One hundred and two patients with prediabetes were divided into a manipulation group and a control group according to the random number table method, with 51 cases in each group. All patients received the general behavioral intervention for prediabetes, with additional Song-Relaxing and Zhen-Vibrating abdomen manipulation in the manipulation group and oral metformin hydrochloride tablets in the control group. Both groups received the intervention for six months.

Results

Fourteen patients dropped out during the treatment, and a total of 88 patients completed the trial, including 45 cases in the manipulation group and 43 cases in the control group. After the treatment, the prediabetes control rate was 93.3% in the manipulation group and 74.4% in the control group, and the difference between the two groups was statistically significant (P<0.05); no patient in the manipulation group progressed to diabetes, while the rate of conversion to diabetes in the control group was 6.9%, with a significant difference between the two groups (P<0.05). After the treatment, the body mass index (BMI), glycosylated hemoglobin A1c (HbA1c), fasting plasma glucose (FPG), 2-hour postload plasma glucose (2hPG) level during an oral glucose tolerance test (OGTT), fasting insulin (FINS), homeostasis model assessment-2 of insulin resistance (HOMA2-IR), total cholesterol (TC), and triglycerides (TG) decreased in both groups versus baseline, with significant differences within the groups; the levels of all indicators were lower in the manipulation group than in the control group (P<0.05), and the differences between the two groups were more prominent at the sixth month (P<0.01). At the sixth month, the high-density lipoprotein cholesterol (HDL-C) in the manipulation group was increased, while there was no significant change in the control group. In the control group, three patients reported mild gastrointestinal reactions at the initial dosing, which improved after medication adjustment. No other adverse events were observed in either group.

Conclusion

Both metformin hydrochloride tablets and the Song-Relaxing and Zhen-Vibrating abdomen manipulation can improve blood glucose and lipid metabolism and reduce insulin resistance and clinical discomfort in patients with prediabetes, but the Song-Relaxing and Zhen-Vibrating abdomen manipulation has higher efficacy and safety.

摘要

目的

观察松振腹法治疗糖尿病前期患者的安全性及其对血糖、 血脂代谢的影响.

方法

将 102 例糖尿病前期患者根据随机数字表法分为手法组和对照组, 每组51例. 所有受试者均接受糖尿病前期一般行为干预, 手法组加用松振腹法, 对照组口服盐酸二甲双胍片. 两组均干预6个月.

结果

治疗期间脱落14例, 共有88名受试者完成试验, 其中手法组45例, 对照组43例. 治疗后, 手法组糖尿病前期控制率为93.3%, 对照组为74.4%, 两组差异有统计学意义 (P<0.05); 手法组无受试者进展为糖尿病, 对照组糖尿病转化率为6.9%, 两组差异有统计学意义(P<0.05). 治疗后两组的体质量指数(BMI)、 糖化血红蛋白(HbA1c)、 空腹血糖(FPG)、 口服葡萄糖耐量试验(OGTT)两小时血糖(2hPG)、 空腹胰岛素(FINS)、 胰岛素抵抗指数(HOMA2-IR)、 总胆固醇(TC)及甘油三酯(TG)均较治疗前降低, 组内差异有统计学意义 (P<0.05); 手法组各指标水平均低于对照组(P<0.05), 第6月时两组差异更显著(P<0.01). 第6个月时, 手法组高密度脂蛋 白胆固醇(HDL-C)升高, 而对照组无显著变化. 对照组中有3例受试者报告初始服药时有轻微胃肠道反应, 用药调整后好转, 两组均未观察到其他不良事件.

结论

盐酸二甲双胍片和松振腹法均可改善糖尿病前期患者血糖及血脂代谢, 减轻胰岛素抵抗程度和临床不适症状, 但松振腹法的疗效和安全性更高.

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Acknowledgments

This work was supported by Key Project of Hunan Province Administration of Traditional Chinese Medicine (湖南省中医药管理局重点科研项目, No. 201526).

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Authors and Affiliations

  1. Hunan University of Chinese Medicine, Changsha, 410208, China

    Min Li  (李敏), Yihui Deng  (邓奕辉) & Qinghu He  (何清湖)

  2. Hunan Traditional Chinese Medical College, Zhuzhou, 412012, China

    Min Li  (李敏), Jiaofei Zeng  (曾姣飞) & Ying Zhou  (周英)

  3. Hunan Want Want Hospital, Changsha, 410016, China

    Na Peng  (彭娜)

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  1. Min Li  (李敏)
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Correspondence to Yihui Deng  (邓奕辉) or Qinghu He  (何清湖).

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Informed consent was obtained from all individual participants.

First Author: LI Min, doctoral candidate, associate professor

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Li, M., Peng, N., Zeng, J. et al. Observation of the efficacy and safety of the Song-Relaxing and Zhen-Vibrating abdomen manipulation for patients with prediabetes. J. Acupunct. Tuina. Sci. 20, 58–64 (2022). https://doi.org/10.1007/s11726-022-1292-x

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