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Effect of Bariatric Surgery on High-Density Lipoprotein (HDL) Cholesterol in Non-diabetic Patients with Severe Obesity

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Abstract

Background

This study evaluated changes in serum high-density lipoprotein cholesterol (HDL-C) induced by laparoscopic bariatric surgery (BS) in non-diabetic obese subjects with low (L-HDL-C) or normal (N-HDL-C) levels of HDL-C. We assessed whether increased HDL-C is associated with weight loss, serum non-HDL cholesterol (non-HDL-C), serum triglycerides (TG), and physical activity (PA) before and 6 and 15 months after BS.

Methods

In this prospective cohort study, 71 subjects undergoing BS (42 by Roux-en-Y gastric bypass and 29 by sleeve gastrectomy) were evaluated for the % Excess Weight Loss (%EWL), waist circumference (WC), serum levels of glucose, glycosylated hemoglobin, TG, HDL-C, non-HDL-C, and LDL-C, and the degree, time, and energy expenditure related to PA. The short version of the International Physical Activity Questionnaire was used to assess PA.

Results

Levels of HDL-C significantly increased 15 months after BS (p < 0.001) in subjects with low (p < 0.001) or normal (p = 0.017) values at baseline. A similar %EWL, decrease in WC, glucose, non-HDL-C, and LDL-C levels and increase in energy expenditure related to PA, was observed in both groups (L-HDL-C and N-HDL-C) at 15 months after BS. However, the L-HDL-C group presented greater decrease in TG levels compared with N-HDL-C group (p = 0.004). In subjects with increased HDL-C 15 months after BS, there was an association between this increase and the %EWL (p = 0.030), but there was no association with the change in PA.

Conclusions

Irrespective of PA after BS, subjects with low and normal HDL-C levels at baseline showed an increase in HDL-C after BS, and this increase was associated with %EWL induced by BS.

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Acknowledgments

The authors would like to thank the team of the Centro de Tratamento da Obesidade of the Hospital Santa Rita from Complexo Hospitalar Irmandade Santa Casa de Misericórdia de Porto Alegre for providing conditions to execute the study and the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) for providing the PhD fellowships.

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Authors and Affiliations

  1. Programa de Pós-Graduação em Ciências da Saúde: Ginecologia e Obstetrícia, UFRGS, Porto Alegre, Brazil

    Otto Henrique Nienov, Fernanda Dapper Machado, Lisiane Stefani Dias & Helena Schmid

  2. Centro de Tratamento da Obesidade, Hospital Santa Rita do Complexo Hospitalar Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, Brazil

    Luiz Alberto De Carli & Helena Schmid

  3. Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil

    Helena Schmid

  4. Departamento de Medicina Interna, UFRGS, Porto Alegre, Brazil

    Helena Schmid

Authors
  1. Otto Henrique Nienov
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  2. Fernanda Dapper Machado
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  3. Lisiane Stefani Dias
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  4. Luiz Alberto De Carli
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  5. Helena Schmid
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Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical Approval

The study was approved by the Ethical Committee of the Hospital (Approval number 51843515.1.0000.5335).

Informed Consent

Written informed consent was obtained for each participant in the study.

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Nienov, O.H., Machado, F.D., Dias, L.S. et al. Effect of Bariatric Surgery on High-Density Lipoprotein (HDL) Cholesterol in Non-diabetic Patients with Severe Obesity. OBES SURG 30, 154–160 (2020). https://doi.org/10.1007/s11695-019-04126-6

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  • DOI: https://doi.org/10.1007/s11695-019-04126-6

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