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Changes in Gut Microbiota and Hormones After Bariatric Surgery: a Bench-to-Bedside Review

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Abstract

Overweight and obesity are among the most prevalent non-communicable diseases which are generally treated successfully by bariatric or sleeve surgery. There are evidences affirming that sleeve surgery can manipulate the pH of the stomach and interact with the metabolism of fatty acids, carbohydrates, and bile acid transfer, leading to the overgrowth of gut microbiota. Therefore, this study aims to review the changes in gut microbiota and hormones after bariatric surgery.

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Acknowledgments

This article is part of the work by Mohsen Tabasi to fulfill the requirement for a PhD degree. We extend our heartfelt gratitude to all who have worked hard to make this project a success.

Funding

This work was financially supported by the Pasteur Institute of Iran (grant no.TP-9567).

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Authors and Affiliations

  1. Department of Molecular Biology, Pasteur Institute of Iran, Pasteur Ave., Tehran, 13164, Iran

    Mohsen Tabasi

  2. Legal Medicine Research Center, Legal Medicine Organization, Tehran, Iran

    Mohsen Tabasi & Amin Radmanesh

  3. Department of Mycobacteriology and Pulmonary Research, Microbiology Research Center, Pasteur Institute of Iran, Tehran, Iran

    Fatemeh Ashrafian, Ava Behrouzi, Sara Ahmadi & Seyed Davar Siadat

  4. Young Researchers and Elite Club, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran

    Jamil Kheirvari Khezerloo

  5. Microbial Pathogenesis and Immunology Department, Texas A&M University, Bryan, TX, USA

    Sahar Eshghjoo

  6. Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran

    Seyed Alireza Javadinia

  7. Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran

    Farid Poursadegh

  8. Department of Epidemiology and Biostatistics, Research Centre for Emerging and Reemerging Infectious Diseases, Pasteur Institute of Iran, Tehran, Iran

    Sana Eybpoosh

  9. Obesity and Eating Habits Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Ahmadreza Soroush

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  1. Mohsen Tabasi
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  2. Fatemeh Ashrafian
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Correspondence to Seyed Davar Siadat.

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Highlights

1. Gut microbiota community is considered a contributing factor in metabolic disorders such as obesity.

2. Bacteroidetes and Firmicutes are two important and dominant phyla in the human gastrointestinal tract.

3. After sleeve surgery, the frequency of Bacteroides, Gammaproteobacteria, Ruminococcus, and Roseovarius increased.

4. Bariatric surgery can help to prevent weight gain by reducing the size of the stomach.

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Tabasi, M., Ashrafian, F., Khezerloo, J.K. et al. Changes in Gut Microbiota and Hormones After Bariatric Surgery: a Bench-to-Bedside Review. OBES SURG 29, 1663–1674 (2019). https://doi.org/10.1007/s11695-019-03779-7

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