Abstract
Neuroimaging studies have identified alterations in functional connectivity between specific brain regions in patients with unilateral hearing loss (UHL) and different influence of the side of UHL on neural plasticity. However, little is known about changes of whole-brain functional networks in patients with UHL and whether differences exist in topological organization between right-sided UHL (RUHL) and left-sided UHL (LUHL). To address this issue, we employed resting-state fMRI (rs-fMRI) and graph-theoretical approaches to investigate the topological alterations of brain functional connectomes in patients with RUHL and LUHL. Data from 44 patients with UHL (including 22 RUHL patients and 22 LUHL patients) and 37 healthy control subjects (HCs) were collected. Functional brain networks were constructed for each participant, following by graph-theoretical network analyses at connectional and global (e.g., small-worldness) levels. The correlations between brain network topologies and clinical variables were further studied. Using network-based analysis, we found a subnetwork in the visual cortex which had significantly lower connectivity strength in patients with RUHL as compared to HCs. At global level, all participants showed small-world architecture in functional brain networks, however, significantly lower normalized clustering coefficient and small-worldness were observed in patients with RUHL than in HCs. Moreover, these abnormal network metrics were demonstrated to be correlated with the clinical variables and cognitive performance of patients with RUHL. Notably, no significant alterations in the functional brain networks were found in patients with LUHL. Our findings demonstrate that RUHL (rather than LUHL) is accompanied with aberrant topological organization of the functional brain connectome, indicating different pathophysiological mechanisms between RUHL and LUHL from a viewpoint of network topology.
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The data and materials of this study are available from the corresponding author on reasonable request.
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Acknowledgements
We want to thank MRI technician Zhong Yang for supporting with the MRI scans. We would also like to thank Yaozhen Pei (neuropsychologist) for her help and contribution in the neuropsychological assessment of the participants of this study.
Funding
This work was supported by the Outstanding Academic Leaders Program of Shanghai Municipal Commission of Health and Family Planning (No. 2017BR006), National Natural Science Foundation of China (No. 81571102, No. 81870911), Clinical Research Plan of SHDC (No. SHDC2020CR2034B), Shanghai Municipal Science and Technology Major Project (No. 2018SHZDZX01), and CAMS Innovation Fund for Medical Sciences (CIFMS, 2019-I2M-5-008).
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Author contributions included conception and study design (Zhi-yuan Fan, Ming-rui Xia and Wei Zhu), data collection or acquisition and clinical support (Zhen Fan, Yuan Shi, Ying-jun Liu and Si-chen Li), statistical analysis (Zhi-yuan Fan, Xiao-yi Sun and Yun-man Xia), interpretation of results (Zhi-yuan Fan, Zhen Fan, Ming-rui Xia and Wei Zhu), drafting the manuscript work or revising it critically for important intellectual content (Zhi-yuan Fan, Tian-ming Qiu, Ming-rui Xia and Wei Zhu), approval of final version to be published and agreement to be accountable for the integrity and accuracy of all aspects of the work (All authors).
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Fan, Z., Fan, Z., Qiu, T. et al. Altered topological properties of the intrinsic functional brain network in patients with right-sided unilateral hearing loss caused by acoustic neuroma. Brain Imaging and Behavior 16, 1873–1883 (2022). https://doi.org/10.1007/s11682-022-00658-1
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DOI: https://doi.org/10.1007/s11682-022-00658-1