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Chinese Medicine Treatment on Graft-Versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation

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Abstract

Graft-versus-host disease (GVHD) is the most common complication after allogeneic hematopoietic stem cell transplantation, and also an important factor affecting the survival and quality of life in patients after transplantation. Currently, immunosuppressive therapy is commonly used for GVHD, but the curative effect is not ideal. How to effectively prevent and treat GVHD is one of the difficulties to be solved urgently in the field of transplantation. In this paper, we summarize the latest progress in pathogenesis, prevention and treatment of GVHD with Chinese medicine (CM). We hope it will provide ideas and methods for exploring the mechanism and establishing a new comprehensive therapy for GVHD with CM.

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Author information

Authors and Affiliations

  1. Institute of Hematology Research, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310006, China

    Xiao-long Wu, Hai-feng Zhuang, Yan-na Zhao, Xiao-ling Yu, Tie-ying Dai & Rui-lan Gao

Authors
  1. Xiao-long Wu
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  2. Hai-feng Zhuang
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  3. Yan-na Zhao
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  4. Xiao-ling Yu
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  6. Rui-lan Gao
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Contributions

Gao RL and Wu XL conceived, designed, collected data and wrote the manuscript. Zhuang HF consulted relevant literature and clinical guidelines. Zhao YN, Yu XL and Dai TY participated in searching and reading the literatures.

Corresponding author

Correspondence to Rui-lan Gao.

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The authors declare that they have no conflict of interest.

Additional information

Supported by the National Natural Science Foundation of China (No. 81774068), the Natural Science Foundation of Zhejiang Province (Youth Project, No. LQ19H290002)

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Wu, Xl., Zhuang, Hf., Zhao, Yn. et al. Chinese Medicine Treatment on Graft-Versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation. Chin. J. Integr. Med. 26, 324–329 (2020). https://doi.org/10.1007/s11655-020-3252-y

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