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Influence of Fuzheng Huayu Tablet (扶正化瘀片) on mental state and social function of patients with post-hepatitis B liver cirrhosis

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Abstract

Objective

To observe the influence of Fuzheng Huayu Tablet (扶正化瘀片, FZHYT) on mental state and social activity of patients with post-hepatitis B liver cirrhosis (LC-HB).

Methods

Adopting grouped randomized double-blinded control method, 180 LC-HB patients in 3 research centers were distributed to 2 groups, the treated group and the control group, 90 in each group. Patients in the treated group were administered with FZHYT; while those in the control group treated with conventional therapy combined with placebo, the course for all patients were 6 months. Their mental state and social activity were evaluated before treatment, after 3 months’ treatment and at terminal of the 6-month therapeutic course by estimating with Zung self-rating anxiety scale (SAS), self-rating depression scale (SDS) and social deficit screening scale (SDSS). Additionally, the basic demographic materials, liver function, cirrhosis index, hepatic and splenic images, blood coagulation function, etc. in the patients were tested and compared as well.

Results

As compared with before treatment, the normal rate of SAS and SDS scores increased and the social deficit rate decreased in the treated group significantly after treatment, showing statistical significance (P<0.05 or P<0.01); while in the control group, change was only shown in the social deficit (P<0.01), inter-group comparisons after treatment showed significant differences in all the three indexes (P<0.05 or P<0.01). Additionally, after treatment, levels of liver function, cirrhosis, blood coagulation function and splenomegaly in the treated group were all improved significantly P<0.05 or P<0.01), and the improvements were better than those in the control group (P<0.01) in levels of total bilirubin (TBIL), albumin (ALB), type IV collagen (IV-C), prothrombin time (PT), prothrombin activity (PTA).

Conclusion

Most patients of LC-HB have mental disturbance and social activity deficit, which could definitely be improved by intervention with Chinese FZHYT.

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Authors and Affiliations

  1. Ruikang Hospital affiliated to Guangxi Traditional Chinese Medicine College, Nanning, 530011, China

    Xin Deng  (邓 鑫), Jian Liang  (梁 健), Fa-sheng Wu  (吴发胜), Yan-bo Li  (李艳波), Ya-ping Zhang  (张亚萍) & Yan-fang Tang  (唐艳芳)

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  1. Xin Deng  (邓 鑫)
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  2. Jian Liang  (梁 健)
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  3. Fa-sheng Wu  (吴发胜)
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  4. Yan-bo Li  (李艳波)
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  5. Ya-ping Zhang  (张亚萍)
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  6. Yan-fang Tang  (唐艳芳)
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Corresponding author

Correspondence to Jian Liang  (梁 健).

Additional information

Supported by Project of Guangxi Science and Technology Department (No. 2010 GXNSFA 013217), Key Project of Guangxi Health Department (No. 2010095) and Guangxi Provincial Fund of Natural Science (No. Gui Ke Zi 0832174)

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Deng, X., Liang, J., Wu, Fs. et al. Influence of Fuzheng Huayu Tablet (扶正化瘀片) on mental state and social function of patients with post-hepatitis B liver cirrhosis. Chin. J. Integr. Med. 18, 466–472 (2012). https://doi.org/10.1007/s11655-012-1112-0

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  • DOI: https://doi.org/10.1007/s11655-012-1112-0

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