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Selective Reoperation for Locally Recurrent or Metastatic Pancreatic Ductal Adenocarcinoma Following Primary Pancreatic Resection

  • Original Article
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Journal of Gastrointestinal Surgery Aims and scope

Abstract

Background

Resection of certain recurrent malignancies can prolong survival, but resection of recurrent pancreatic ductal adenocarcinoma is typically contraindicated because of poor outcomes.

Methods

All patients from 1992 to 2010 with recurrent pancreatic cancer after intended surgical cure were retrospectively evaluated. Clinicopathologic features were compared from patients who did and did not undergo subsequent reoperation with curative intent to identify factors associated with prolonged survival.

Results

Twenty-one of 426 patients (5 %) with recurrent pancreatic cancer underwent potentially curative reoperation for solitary local-regional (n = 7) or distant (n = 14) recurrence. The median disease-free interval after initial resection among reoperative patients was longer for those with lung or local-regional recurrence (52.4 and 41.1 months, respectively) than for those with liver recurrence (7.6 months, p = 0.006). The median interval between reoperation and second recurrence was longer in patients with lung recurrence (median not reached) than with liver or local-regional recurrence (6 and 9 months, respectively, p = 0.023). Reoperative patients with an initial disease-free interval >20 months had a longer median survival than those who did not (92.3 versus 31.3 months, respectively; p = 0.033).

Conclusion

Patients with a solitary pulmonary recurrence of pancreatic cancer after a prolonged disease-free interval should be considered for reoperation, as they are more likely to benefit from resection versus other sites of solitary recurrence.

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Authors and Affiliations

  1. Department of Surgical Oncology, Unit 444, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA

    Ryan M. Thomas, Mark J. Truty, Jason B. Fleming, Jean-Nicolas Vauthey, Peter W. T. Pisters, Jeffrey E. Lee & Matthew H. G. Katz

  2. Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA

    Graciela M. Nogueras-Gonzalez

  3. Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA

    David C. Rice & Wayne L. Hofstetter

  4. Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA

    Robert A. Wolff & Gauri R. Varadhachary

  5. Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA

    Huamin Wang

Authors
  1. Ryan M. Thomas
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  2. Mark J. Truty
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  13. Matthew H. G. Katz
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Corresponding author

Correspondence to Matthew H. G. Katz.

Additional information

Grant Support: This study was supported by the Khalifa Bin Zayed Al Nahyan Foundation, various donors to the Pancreatic Research Fund at MD Anderson Cancer Center, and the National Institutes of Health through MD Anderson's Cancer Center Support Grant CA016672. Recipient of the 2012 ASCO Conquer Cancer Foundation Merit Award, American Society of Clinical Oncology.

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Thomas, R.M., Truty, M.J., Nogueras-Gonzalez, G.M. et al. Selective Reoperation for Locally Recurrent or Metastatic Pancreatic Ductal Adenocarcinoma Following Primary Pancreatic Resection. J Gastrointest Surg 16, 1696–1704 (2012). https://doi.org/10.1007/s11605-012-1912-8

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  • DOI: https://doi.org/10.1007/s11605-012-1912-8

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