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Pediatric living donor left lateral segment liver transplantation for biliary atresia: Doppler ultrasound findings in early postoperative period

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Abstract

Purpose

To analyze hepatic hemodynamic parameters detected by Doppler ultrasound (DU) of uncomplicated children with biliary atresia who underwent left lateral segment living donor liver transplantation (LLS-LDLT), explore its normal change trend over time and determine the normal reference interval.

Methods

We retrospectively involved the data from 227 biliary atresia patients (100 Males,127 Females). Hemodynamic parameters include peak systolic velocity (PSV), end-diastolic velocity (EDV), resistivity index (RI), and pulsation index (PI) of the hepatic artery (HA), portal vein velocity (PVV), portal vein flow (PVF) and hepatic vein velocity (HVV) during intra-operative and on the 1st, 3rd, 5th and 7th day after operation were collected. Repeated measures analysis of the variance and Friedman test were used to analyze the changing trend of hemodynamic parameters over time in the first week after the operation.

Results

PSVHA and EDVHA showed a similar changing tendency at one week after surgery, with an overall decrease-rise trend; RIHA and PIHA also changed similarly with an overall rise-decrease trend. The HVV and PVV at surgery were lower than at all time points after surgery. As for PVF, the value of POD5 was the highest and then decreased. Additionally, this study provided the normal reference interval of hemodynamic parameters for LLS-LDLT patients, which were PSVHA: 18.4–98.3 cm/s, EDVHA: 0–43.3 cm/s, RIHA: 0.41–1.0, PIHA: 0.51–2.0, PVV: 19.0–83.7 cm/s, HVV: 19.4–68.0 cm/s, and PVF:99.5–500.0 ml/min/100 g at intraoperation. Within the first postoperative week: PSVHA: 21.0–97.7 cm/s, EDVHA: 0–32.7 cm/s, RIHA: 0.47–1.0, PIHA: 0.62–2.0, PVV: 23.0–92.0 cm/s, HVV: 19.7–86.0 cm/s, and PVF: 100.0–513.0 ml/min/100 g.

Conclusion

The hepatic hemodynamic of post-transplanted children detected by DU had specific changing trends and normal ranges, which provides valuable reference values for ultrasonologists and pediatric transplant clinicians.

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Funding

Tianjin Major Science and Technology Foundation (18ZXZNSY00250).

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Authors and Affiliations

  1. Department of Ultrasound, Tianjin First Central Hospital, No. 24 Fukang Road, Nankai District, Tianjin, 300192, China

    Ying Tang, Guoying Zhang, Weina Kong, Huimin Yu, Ningning Niu, Jing Liu & Yang Liu

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  1. Ying Tang
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  2. Guoying Zhang
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  3. Weina Kong
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Correspondence to Ying Tang.

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Tang, Y., Zhang, G., Kong, W. et al. Pediatric living donor left lateral segment liver transplantation for biliary atresia: Doppler ultrasound findings in early postoperative period. Jpn J Radiol 39, 367–375 (2021). https://doi.org/10.1007/s11604-020-01067-4

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  • DOI: https://doi.org/10.1007/s11604-020-01067-4

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