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CT findings in diagnosis of gastric bare area invasion: potential prognostic factors for proximal gastric carcinoma

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Japanese Journal of Radiology Aims and scope Submit manuscript

Abstract

Purpose

To investigate the correlation between the preoperative CT findings in diagnosis of gastric bare area (GBA) invasion and the 3-year-overall survival (OS) of patients with proximal gastric carcinoma (PGC).

Methods

108 consecutive patients with PGC confirmed by biopsy underwent MDCT scan prior to gastrectomy were enrolled retrospectively from Dec 2009 to Dec 2014. GBA invasion in PGC were evaluated by measuring the direct CT signs including transmural involvement and lymph nodes in the GBA. The indirect signs were also evaluated including the infiltration of the diaphragm, gastrophrenic ligament and perigastric fat. Kaplan–Meier estimates with log-rank test and Cox proportional hazard model were used for analysis.

Results

The two raters achieved excellent agreement. Univariate Kaplan–Meier estimates indicated that postoperative chemotherapy (p = 0.003), transmural involvement (p < 0.001), lymph nodes in the GBA (p = 0.015) and cT staging (p = 0.002) were associated with OS. Cox proportional hazard model indicated that the transmural involvement (HR = 8.194, 95% CI 2.15–31.266), diaphragm involvement (HR = 0.21, 95% CI 0.042–0.986), perigastric fat infiltration (HR = 0.125, 95% CI 0.018–0.885; HR = 0.02, 95% CI 0.001–0.264), and cT staging were independent prognostic factors for OS.

Conclusion

CT findings of GBA invasion in patients with PGC, not only the transmural involvement but also the indirect signs are independent prognostic factors potentially, which should be given more emphasis in future clinical practice.

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Abbreviations

PGC:

Proximal gastric carcinoma

GBA:

Gastric bare area

MDCT:

Multidetector computed tomography

cT:

Clinical T stage

pT:

Pathological T stages

LN:

Lymph nodes

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Acknowledgements

This study was supported by Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support (no. ZYLX201803) and Beijing Natural Science Foundation (7172049).

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Authors and Affiliations

  1. From Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Radiology, Peking University Cancer Hospital and Institute, No. 52 Fu Cheng Road, Hai Dian District, Beijing, 100142, China

    Rui-Jia Sun, Lei Tang, Xiao-Ting Li & Ying-Shi Sun

  2. From Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Surgery, Peking University Cancer Hospital and Institute, No. 52 Fu Cheng Road, Hai Dian District, Beijing, 100142, China

    Zi-Yu Li

Authors
  1. Rui-Jia Sun
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  2. Lei Tang
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  4. Zi-Yu Li
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Contributions

Y-SS is acting as the guarantor of the article, and was responsible for the study design and for preparation of the manuscript. R-JS and LT were responsible for the study design and data collection. X-TL and Z-YL were responsible for development of methodology. All co-authors had input into study design, conduct, data analysis or interpretation. All co-authors critically reviewed the manuscript, and necessary revisions were made to accommodate their suggestions and opinions.

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Correspondence to Ying-Shi Sun.

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The authors have no conflicts of interest to declare.

Ethical statement

This retrospective study was approved by the institutional review board of our institute, and the requirement of informed consent was waived.

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Sun, RJ., Tang, L., Li, XT. et al. CT findings in diagnosis of gastric bare area invasion: potential prognostic factors for proximal gastric carcinoma. Jpn J Radiol 37, 518–525 (2019). https://doi.org/10.1007/s11604-019-00837-z

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  • DOI: https://doi.org/10.1007/s11604-019-00837-z

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